Abnormal conduction in corticospinal pathways in Wilson's disease: Investigation of nine cases with magnetic brain stimulation
Identifieur interne : 004345 ( Istex/Checkpoint ); précédent : 004344; suivant : 004346Abnormal conduction in corticospinal pathways in Wilson's disease: Investigation of nine cases with magnetic brain stimulation
Auteurs : Meyer [Allemagne] ; T. C. Britton [Allemagne] ; C. Bischoff [Allemagne] ; J. Machetanz [Allemagne] ; R. Benecke [Allemagne] ; B. Conrad [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1991.
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Abstract
Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.
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DOI: 10.1002/mds.870060409
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="320">320</biblScope><biblScope unit="page" to="323">323</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">887C1BD18DCBEEFF2A52BEDA62EEA409C8B0F6A7</idno><idno type="DOI">10.1002/mds.870060409</idno><idno type="ArticleID">MDS870060409</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Wilson's disease</term><term>motor responses</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Meyer" sort="Meyer" uniqKey="Meyer" last="Meyer">Meyer</name></region><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R." last="Benecke">R. 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