Bilateral posteroventral pallidotomy in advanced parkinson's disease in three patients
Identifieur interne : 003A23 ( Istex/Checkpoint ); précédent : 003A22; suivant : 003A24Bilateral posteroventral pallidotomy in advanced parkinson's disease in three patients
Auteurs : Schuurman [Pays-Bas] ; Rob M. A. De Bie [Pays-Bas] ; Johannes D. Speelman [Pays-Bas] ; D. Andries Bosch [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-09.
English descriptors
Abstract
In this report, we describe the effect of staged bilateral posteroventral pallidotomy in three patients with advanced Parkinson's disease who were all of the young‐onset type. Two patients had developed response fluctuations after the use of levodopa, with severe hypokinesia, painful dystonia, and rigidity in the “off” phase and violent dyskinesias in the “on” phase. One patient, in a continuous hypokinetic rigid state, was totally unresponsive to dopaminergic medication. All were at Hoehn and Yahr stage 5 in the “off” phase before surgery. After surgery, the hypokinetic state was reversed and dyskinesias were abolished in all patients. Hoehn and Yahr stages were 3 in the “off” phase postoperatively. Overall functional improvement was marked and lasting after follow‐up for 7, 12, and 13 months, respectively. Complications were visual field deficit and transient central facial paresis, both in the same patient. Bilateral posteroventral pallidotomy can ameliorate response fluctuations, hypokinesia, rigidity, and painful dystonia in advanced Parkinson's disease.
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DOI: 10.1002/mds.870120521
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ISTEX:5EB2019F253C82A9BBA4FA8F4C7F5AF96D6D638FLe document en format XML
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<front><div type="abstract" xml:lang="en">In this report, we describe the effect of staged bilateral posteroventral pallidotomy in three patients with advanced Parkinson's disease who were all of the young‐onset type. Two patients had developed response fluctuations after the use of levodopa, with severe hypokinesia, painful dystonia, and rigidity in the “off” phase and violent dyskinesias in the “on” phase. One patient, in a continuous hypokinetic rigid state, was totally unresponsive to dopaminergic medication. All were at Hoehn and Yahr stage 5 in the “off” phase before surgery. After surgery, the hypokinetic state was reversed and dyskinesias were abolished in all patients. Hoehn and Yahr stages were 3 in the “off” phase postoperatively. Overall functional improvement was marked and lasting after follow‐up for 7, 12, and 13 months, respectively. Complications were visual field deficit and transient central facial paresis, both in the same patient. Bilateral posteroventral pallidotomy can ameliorate response fluctuations, hypokinesia, rigidity, and painful dystonia in advanced Parkinson's disease.</div>
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