Dopaminergic influence on disturbed spatial discrimination in Parkinson's disease
Identifieur interne : 002359 ( Istex/Checkpoint ); précédent : 002358; suivant : 002360Dopaminergic influence on disturbed spatial discrimination in Parkinson's disease
Auteurs : Hae-Won Shin [Corée du Sud] ; Suk Y. Kang [Corée du Sud] ; Young H. Sohn [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
English descriptors
Abstract
Various sensory symptoms and disturbed sensory perception are often observed in patients with idiopathic Parkinson's disease (PD). The basis of sensory disturbance in PD is unknown but possibly reflects a role for the basal ganglia in sensory processing. To investigate the relationship between the sensory dysfunction and dopaminergic deficiency in PD, we measured spatial discrimination using the Grating Orientation Task in 21 drug‐naive patients with PD, before and after long‐term antiparkinson therapy, and 25 age‐matched healthy controls. The grating orientation threshold was significantly higher in patients (3.03 ± 0.84) than controls (2.03 ± 0.79). After 3 to 10 months of antiparkinson therapy, the grating orientation threshold was significantly lowered (2.66 ± 0.84), although it was still higher than that in controls. Improvement in the patients' sensory function was significantly correlated with motor improvement (r = 0.44). These results suggest that sensory dysfunction in Parkinson's disease is related at least in part to the dopaminergic deficit. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20642
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1640">1640</biblScope><biblScope unit="page" to="1643">1643</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1C89C7FB6DA89D31A27C9424541406589BE78652</idno><idno type="DOI">10.1002/mds.20642</idno><idno type="ArticleID">MDS20642</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dopamine</term><term>grating orientation threshold</term><term>sensation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Various sensory symptoms and disturbed sensory perception are often observed in patients with idiopathic Parkinson's disease (PD). The basis of sensory disturbance in PD is unknown but possibly reflects a role for the basal ganglia in sensory processing. To investigate the relationship between the sensory dysfunction and dopaminergic deficiency in PD, we measured spatial discrimination using the Grating Orientation Task in 21 drug‐naive patients with PD, before and after long‐term antiparkinson therapy, and 25 age‐matched healthy controls. The grating orientation threshold was significantly higher in patients (3.03 ± 0.84) than controls (2.03 ± 0.79). After 3 to 10 months of antiparkinson therapy, the grating orientation threshold was significantly lowered (2.66 ± 0.84), although it was still higher than that in controls. Improvement in the patients' sensory function was significantly correlated with motor improvement (r = 0.44). These results suggest that sensory dysfunction in Parkinson's disease is related at least in part to the dopaminergic deficit. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Shin, Hae On" sort="Shin, Hae On" uniqKey="Shin H" first="Hae-Won" last="Shin">Hae-Won Shin</name></noRegion><name sortKey="Kang, Suk Y" sort="Kang, Suk Y" uniqKey="Kang S" first="Suk Y." last="Kang">Suk Y. Kang</name><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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