Improvement in a quantitative measure of bradykinesia after microelectrode recording in patients with Parkinson's disease during deep brain stimulation surgery
Identifieur interne : 001E44 ( Istex/Checkpoint ); précédent : 001E43; suivant : 001E45Improvement in a quantitative measure of bradykinesia after microelectrode recording in patients with Parkinson's disease during deep brain stimulation surgery
Auteurs : Mandy Miller Koop [États-Unis] ; Amy Andrzejewski [États-Unis] ; Bruce C. Hill [États-Unis] ; Gary Heit [États-Unis] ; Helen M. Bronte-Stewart [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-05.
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Abstract
It is widely accepted that patients with Parkinson's disease experience immediate but temporary improvement in motor signs after surgical implantation of subthalamic nucleus (STN) deep brain stimulating electrodes before the electrodes are activated, although this has never been formally studied. Based on anecdotal observations that limb mobility improved just after microelectrode recording (MER) during deep brain stimulation (DBS) procedures, we designed a prospective study to measure upper extremity bradykinesia using a quantitative measure of angular velocity. Measurements were made pre‐ and post‐MER and during intraoperative DBS. Analysis of 98 STN DBS procedures performed on 61 patients showed that MER did not create adverse clinical symptoms despite concerns that MER increases morbidity. Quantitative upper extremity bradykinesia improved after MER alone, and further improvement was seen during intraoperative DBS. Electrophysiological data from each case were then compared to the improvement in bradykinesia post‐MER alone and a significant correlation was found between the improvement in arm bradykinesia, the number of passes through the STN with somatosensory driving, and also with the number of arm cells with somatosensory driving in the STN, but not with total number of passes, total number of passes through the STN, or total number of cells with somatosensory driving in the STN. This study demonstrates that there is a significant improvement in upper extremity bradykinesia just after MER, before inserting or activating the DBS electrode in patients with Parkinson's disease who undergo STN DBS. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20796
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Bronte-Stewart</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C17ADB43126FFA8B6BF8DB379660D428C8932FF2</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20796</idno><idno type="url">https://api.istex.fr/document/C17ADB43126FFA8B6BF8DB379660D428C8932FF2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000F28</idno><idno type="wicri:Area/Istex/Curation">000F28</idno><idno type="wicri:Area/Istex/Checkpoint">001E44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Improvement in a quantitative measure of bradykinesia after microelectrode recording in patients with Parkinson's disease during deep brain stimulation surgery</title><author><name sortKey="Koop, Mandy Miller" sort="Koop, Mandy Miller" uniqKey="Koop M" first="Mandy Miller" last="Koop">Mandy Miller Koop</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Andrzejewski, Amy" sort="Andrzejewski, Amy" uniqKey="Andrzejewski A" first="Amy" last="Andrzejewski">Amy Andrzejewski</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hill, Bruce C" sort="Hill, Bruce C" uniqKey="Hill B" first="Bruce C." last="Hill">Bruce C. Hill</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Heit, Gary" sort="Heit, Gary" uniqKey="Heit G" first="Gary" last="Heit">Gary Heit</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kaiser Permanente, Redwood City, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bronte Tewart, Helen M" sort="Bronte Tewart, Helen M" uniqKey="Bronte Tewart H" first="Helen M." last="Bronte-Stewart">Helen M. Bronte-Stewart</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Stanford University, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-05">2006-05</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="673">673</biblScope><biblScope unit="page" to="678">678</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C17ADB43126FFA8B6BF8DB379660D428C8932FF2</idno><idno type="DOI">10.1002/mds.20796</idno><idno type="ArticleID">MDS20796</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>bradykinesia</term><term>microelectrode recording</term><term>quantitative repetitive wrist pronation–supination</term><term>subthalamic nucleus deep brain stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is widely accepted that patients with Parkinson's disease experience immediate but temporary improvement in motor signs after surgical implantation of subthalamic nucleus (STN) deep brain stimulating electrodes before the electrodes are activated, although this has never been formally studied. Based on anecdotal observations that limb mobility improved just after microelectrode recording (MER) during deep brain stimulation (DBS) procedures, we designed a prospective study to measure upper extremity bradykinesia using a quantitative measure of angular velocity. Measurements were made pre‐ and post‐MER and during intraoperative DBS. Analysis of 98 STN DBS procedures performed on 61 patients showed that MER did not create adverse clinical symptoms despite concerns that MER increases morbidity. Quantitative upper extremity bradykinesia improved after MER alone, and further improvement was seen during intraoperative DBS. Electrophysiological data from each case were then compared to the improvement in bradykinesia post‐MER alone and a significant correlation was found between the improvement in arm bradykinesia, the number of passes through the STN with somatosensory driving, and also with the number of arm cells with somatosensory driving in the STN, but not with total number of passes, total number of passes through the STN, or total number of cells with somatosensory driving in the STN. This study demonstrates that there is a significant improvement in upper extremity bradykinesia just after MER, before inserting or activating the DBS electrode in patients with Parkinson's disease who undergo STN DBS. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Koop, Mandy Miller" sort="Koop, Mandy Miller" uniqKey="Koop M" first="Mandy Miller" last="Koop">Mandy Miller Koop</name></region><name sortKey="Andrzejewski, Amy" sort="Andrzejewski, Amy" uniqKey="Andrzejewski A" first="Amy" last="Andrzejewski">Amy Andrzejewski</name><name sortKey="Bronte Tewart, Helen M" sort="Bronte Tewart, Helen M" uniqKey="Bronte Tewart H" first="Helen M." last="Bronte-Stewart">Helen M. Bronte-Stewart</name><name sortKey="Bronte Tewart, Helen M" sort="Bronte Tewart, Helen M" uniqKey="Bronte Tewart H" first="Helen M." last="Bronte-Stewart">Helen M. Bronte-Stewart</name><name sortKey="Heit, Gary" sort="Heit, Gary" uniqKey="Heit G" first="Gary" last="Heit">Gary Heit</name><name sortKey="Hill, Bruce C" sort="Hill, Bruce C" uniqKey="Hill B" first="Bruce C." last="Hill">Bruce C. Hill</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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