Predictors of weight loss in Parkinson's disease
Identifieur interne : 001D15 ( Istex/Checkpoint ); précédent : 001D14; suivant : 001D16Predictors of weight loss in Parkinson's disease
Auteurs : Ergun Y. Uc [États-Unis] ; Lynn K. Struck [États-Unis] ; Robert L. Rodnitzky [États-Unis] ; Bridget Zimmerman [États-Unis] ; Judith Dobson [États-Unis] ; William J. Evans [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
English descriptors
Abstract
The objective of this study was to examine the change of body weight (BW) among Parkinson's disease (PD) patients and controls over years and determine the predictors of weight loss among PD patients. Studies on weight loss in PD studies are cross‐sectional, have a short follow‐up, or lack in clinical detail. We examined the percentage of BW change over years among 49 PD patients and 78 controls. The controls were from another study on longitudinal evolution of BW and body composition in the elderly. We determined the BW, Hoehn and Yahr (HY) stage, and dyskinesia status of 49 consecutive nondemented PD patients with symptom duration of 6.1 ± 0.7 years (mean ± SEM) and ascertained their BW at the time of diagnosis and 2.4 ± 0.2 years before the diagnosis from medical records. We collected data again 7.2 ± 0.5 years after the first visit. The PD group lost 7.7% ± 1.5% of BW over the entire symptomatic period (13.1 ± 0.8 years), while the control group lost only 0.2% ± 0.7% of BW over 9.9 ± 0.1 years; weight loss was clinically significant (>5%) in 55.6% of PD patients vs. 20.5% of the controls (both P values < 0.001, adjusted for sex, baseline age, and observation period duration). PD patients lost weight in both the early and advanced phases. While worsening of parkinsonism was the most important factor, age at diagnosis, emergence of visual hallucinations, and possibly dementia were also associated with weight loss. We demonstrated significant weight loss in PD patients compared to controls over approximately 1 decade. Neurodegeneration involving both motor and nonmotor systems may be associated with weight loss in PD. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20837
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Rodnitzky</name></author><author><name sortKey="Zimmerman, Bridget" sort="Zimmerman, Bridget" uniqKey="Zimmerman B" first="Bridget" last="Zimmerman">Bridget Zimmerman</name></author><author><name sortKey="Dobson, Judith" sort="Dobson, Judith" uniqKey="Dobson J" first="Judith" last="Dobson">Judith Dobson</name></author><author><name sortKey="Evans, William J" sort="Evans, William J" uniqKey="Evans W" first="William J." last="Evans">William J. 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Uc</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology Service, Veterans Affairs Medical Center, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Struck, Lynn K" sort="Struck, Lynn K" uniqKey="Struck L" first="Lynn K." last="Struck">Lynn K. Struck</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Iowa Health Physicians, Des Moines, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Rodnitzky, Robert L" sort="Rodnitzky, Robert L" uniqKey="Rodnitzky R" first="Robert L." last="Rodnitzky">Robert L. Rodnitzky</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Zimmerman, Bridget" sort="Zimmerman, Bridget" uniqKey="Zimmerman B" first="Bridget" last="Zimmerman">Bridget Zimmerman</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Dobson, Judith" sort="Dobson, Judith" uniqKey="Dobson J" first="Judith" last="Dobson">Judith Dobson</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Evans, William J" sort="Evans, William J" uniqKey="Evans W" first="William J." last="Evans">William J. Evans</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Geriatrics, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas</wicri:regionArea><placeName><region type="state">Arkansas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="930">930</biblScope><biblScope unit="page" to="936">936</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B9C09EAB45301691F3B0E6C18CF457D8D99713CF</idno><idno type="DOI">10.1002/mds.20837</idno><idno type="ArticleID">MDS20837</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>body mass index</term><term>dementia</term><term>hallucinations</term><term>weight loss</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to examine the change of body weight (BW) among Parkinson's disease (PD) patients and controls over years and determine the predictors of weight loss among PD patients. Studies on weight loss in PD studies are cross‐sectional, have a short follow‐up, or lack in clinical detail. We examined the percentage of BW change over years among 49 PD patients and 78 controls. The controls were from another study on longitudinal evolution of BW and body composition in the elderly. We determined the BW, Hoehn and Yahr (HY) stage, and dyskinesia status of 49 consecutive nondemented PD patients with symptom duration of 6.1 ± 0.7 years (mean ± SEM) and ascertained their BW at the time of diagnosis and 2.4 ± 0.2 years before the diagnosis from medical records. We collected data again 7.2 ± 0.5 years after the first visit. The PD group lost 7.7% ± 1.5% of BW over the entire symptomatic period (13.1 ± 0.8 years), while the control group lost only 0.2% ± 0.7% of BW over 9.9 ± 0.1 years; weight loss was clinically significant (>5%) in 55.6% of PD patients vs. 20.5% of the controls (both P values < 0.001, adjusted for sex, baseline age, and observation period duration). PD patients lost weight in both the early and advanced phases. While worsening of parkinsonism was the most important factor, age at diagnosis, emergence of visual hallucinations, and possibly dementia were also associated with weight loss. We demonstrated significant weight loss in PD patients compared to controls over approximately 1 decade. Neurodegeneration involving both motor and nonmotor systems may be associated with weight loss in PD. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arkansas</li><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Uc, Ergun Y" sort="Uc, Ergun Y" uniqKey="Uc E" first="Ergun Y." last="Uc">Ergun Y. 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