GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma
Identifieur interne : 001942 ( Istex/Checkpoint ); précédent : 001941; suivant : 001943GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma
Auteurs : John C. Mchugh [Irlande (pays)] ; Brian Murray [Irlande (pays)] ; Radhakrishnan Renganathan [Irlande (pays)] ; Sean Connolly [Irlande (pays)] ; Tim Lynch [Irlande (pays)]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-15.
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Abstract
Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti‐GAD positive PSPS in a 53‐year‐old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21374
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Mchugh</name></author><author><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name></author><author><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name></author><author><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name></author><author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1CA19F5C042BAD965EFC9068ED0435F185A3C9BE</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21374</idno><idno type="url">https://api.istex.fr/document/1CA19F5C042BAD965EFC9068ED0435F185A3C9BE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003242</idno><idno type="wicri:Area/Istex/Curation">003242</idno><idno type="wicri:Area/Istex/Checkpoint">001942</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma</title><author><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C." last="Mchugh">John C. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-15">2007-07-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1343">1343</biblScope><biblScope unit="page" to="1346">1346</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1CA19F5C042BAD965EFC9068ED0435F185A3C9BE</idno><idno type="DOI">10.1002/mds.21374</idno><idno type="ArticleID">MDS21374</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>GAD</term><term>IVIG</term><term>paraneoplastic</term><term>stiff person syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti‐GAD positive PSPS in a 53‐year‐old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li></country></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Mchugh, John C" sort="Mchugh, John C" uniqKey="Mchugh J" first="John C." last="Mchugh">John C. Mchugh</name></noRegion><name sortKey="Connolly, Sean" sort="Connolly, Sean" uniqKey="Connolly S" first="Sean" last="Connolly">Sean Connolly</name><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><name sortKey="Murray, Brian" sort="Murray, Brian" uniqKey="Murray B" first="Brian" last="Murray">Brian Murray</name><name sortKey="Renganathan, Radhakrishnan" sort="Renganathan, Radhakrishnan" uniqKey="Renganathan R" first="Radhakrishnan" last="Renganathan">Radhakrishnan Renganathan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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