Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes
Identifieur interne : 001767 ( Istex/Checkpoint ); précédent : 001766; suivant : 001768Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes
Auteurs : Birgit Herting [Allemagne] ; Bettina Beuthien-Baumann [Allemagne] ; Katrin Pöttrich [Allemagne] ; Markus Donix [Allemagne] ; Antje Triemer [Allemagne] ; Johannes B. Lampe [Allemagne] ; Rüdiger Von Kummer [Allemagne] ; Karl Herholz [Royaume-Uni] ; Heinz Reichmann [Allemagne] ; Vjera A. Holthoff [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-03-15.
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Abstract
Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal–subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age‐matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with 18F‐fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel‐based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21237
Affiliations:
- Allemagne, Royaume-Uni
- Angleterre, District de Dresde, Saxe (Land)
- Dresde
- Université technique de Dresde
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-03-15">2007-03-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="490">490</biblScope><biblScope unit="page" to="497">497</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A43B0A917467E2851A077B30164C622F8DD0A8D8</idno><idno type="DOI">10.1002/mds.21237</idno><idno type="ArticleID">MDS21237</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>depression</term><term>emission‐computed</term><term>frontal lobe</term><term>multiple system atrophy</term><term>progressive supranuclear palsy</term><term>tomography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depressive symptoms are common in patients with neurodegenerative disorders. Imaging studies suggest that a disruption of frontal–subcortical pathways may underlie depression associated with basal ganglia disease. This pilot study tested the hypothesis that frontal dysfunction contributes to depression associated with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Depressed patients with MSA (n = 11), PSP (n = 9), and age‐matched controls (n = 25) underwent measures of cerebral glucose metabolism applying positron emission tomography with 18F‐fluorodeoxyglucose. Regional metabolism in the patient groups was compared to the normal subjects using the voxel‐based statistical parametric mapping. Depressive symptom severity (Hamilton Depression Rating) and degree of locomotor disability (Hoehn & Yahr) were assessed in the patient groups. The association between prefrontal metabolism and the occurrence of depressive symptoms and the degree of locomotor disability was investigated. When compared to controls, MSA patients revealed significant metabolic decreases in bilateral frontal, parietal, and cerebellar cortex and in the left putamen. In PSP patients, significant hypometabolism was demonstrated in bilateral frontal cortex, right thalamus, and midbrain. Depression severity but not the patients' functional condition was significantly associated with dorsolateral prefrontal glucose metabolism in both patient groups. The findings of this pilot study support the hypothesis that depressive symptoms in MSA and PSP are associated with prefrontal dysfunction. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Dresde</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li></settlement><orgName><li>Université technique de Dresde</li></orgName></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Herting, Birgit" sort="Herting, Birgit" uniqKey="Herting B" first="Birgit" last="Herting">Birgit Herting</name></region><name sortKey="Beuthien Aumann, Bettina" sort="Beuthien Aumann, Bettina" uniqKey="Beuthien Aumann B" first="Bettina" last="Beuthien-Baumann">Bettina Beuthien-Baumann</name><name sortKey="Donix, Markus" sort="Donix, Markus" uniqKey="Donix M" first="Markus" last="Donix">Markus Donix</name><name sortKey="Holthoff, Vjera A" sort="Holthoff, Vjera A" uniqKey="Holthoff V" first="Vjera A." last="Holthoff">Vjera A. Holthoff</name><name sortKey="Lampe, Johannes B" sort="Lampe, Johannes B" uniqKey="Lampe J" first="Johannes B." last="Lampe">Johannes B. Lampe</name><name sortKey="Pottrich, Katrin" sort="Pottrich, Katrin" uniqKey="Pottrich K" first="Katrin" last="Pöttrich">Katrin Pöttrich</name><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><name sortKey="Triemer, Antje" sort="Triemer, Antje" uniqKey="Triemer A" first="Antje" last="Triemer">Antje Triemer</name><name sortKey="Von Kummer, Rudiger" sort="Von Kummer, Rudiger" uniqKey="Von Kummer R" first="Rüdiger" last="Von Kummer">Rüdiger Von Kummer</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Herholz, Karl" sort="Herholz, Karl" uniqKey="Herholz K" first="Karl" last="Herholz">Karl Herholz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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