Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia.
Identifieur interne : 000034 ( Hal/Curation ); précédent : 000033; suivant : 000035Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia.
Auteurs : David Grabli [France] ; Claire Ewenczyk [France] ; Maria-Clara Coelho-Braga [France] ; Christelle Lagrange [France] ; Valerie Fraix [France] ; Philippe Cornu [France] ; Alim-Louis Benabid [France] ; Marie Vidailhet [France] ; Pierre Pollak [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-12-15.
Abstract
Stimulation (DBS) of the globus pallidus (GP) is effective to treat generalized dystonia. Little is known about the evolution of dystonia in case of arrest after a long period of stimulation. This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video-based analysis was performed using Burke-Fahn-Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF-stimulation period. The dystonia movement score progressively worsened from 24.3 +/- 13.9 at baseline to 48.9 +/- 19.8 after 48 hours (P < 0.00001). The disability score also worsened from 4.4 +/- 1.2 at baseline to 5.7 +/- 1.5 after 48 hours without stimulation (P < 0.001). When the neurostimulator was turned ON, the dystonia scores returned to baseline level after 10 hours. The interruption of GP DBS in dystonia results in a progressive worsening which is rapidly reversible once the neurostimulator is turned ON.
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DOI: 10.1002/mds.22827
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Hôpitaux de Paris (AP-HP)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300887" type="direct"><org type="institution" xml:id="struct-300887" status="INCOMING"><orgName>Hôpital Pitié-Salpêtrière</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName><orgName type="acronym">UPMC</orgName><desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.upmc.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ewenczyk, Claire" sort="Ewenczyk, Claire" uniqKey="Ewenczyk C" first="Claire" last="Ewenczyk">Claire Ewenczyk</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-41019" status="VALID"><orgName>Service de neuro-chirurgie [Pitié-Salpétrière]</orgName><desc><address><addrLine>47-83, boulevard de l'Hôpital 75651 Paris Cedex 13</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300068" type="direct"></relation><relation active="#struct-300887" type="direct"></relation><relation active="#struct-93591" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"><orgName>Assistance publique - 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Hôpitaux de Paris (AP-HP)</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300887" type="direct"><org type="institution" xml:id="struct-300887" status="INCOMING"><orgName>Hôpital Pitié-Salpêtrière</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName><orgName type="acronym">UPMC</orgName><desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine><country key="FR"></country></address><ref type="url">http://www.upmc.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-14242" status="VALID"><orgName>Département de neurologie</orgName><desc><address><addrLine>Grenoble</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation active="#struct-300071" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID"><orgName>CHU Grenoble</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author></analytic><idno type="DOI">10.1002/mds.22827</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2009-12-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stimulation (DBS) of the globus pallidus (GP) is effective to treat generalized dystonia. Little is known about the evolution of dystonia in case of arrest after a long period of stimulation. This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video-based analysis was performed using Burke-Fahn-Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF-stimulation period. The dystonia movement score progressively worsened from 24.3 +/- 13.9 at baseline to 48.9 +/- 19.8 after 48 hours (P < 0.00001). The disability score also worsened from 4.4 +/- 1.2 at baseline to 5.7 +/- 1.5 after 48 hours without stimulation (P < 0.001). When the neurostimulator was turned ON, the dystonia scores returned to baseline level after 10 hours. The interruption of GP DBS in dystonia results in a progressive worsening which is rapidly reversible once the neurostimulator is turned ON.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia.</title><author role="crp"><persName><forename type="first">David</forename><surname>Grabli</surname></persName><email>david.grabli@psl.aphp.fr</email><idno type="halauthor">536741</idno><affiliation ref="#struct-41019"></affiliation><affiliation ref="#struct-3037"></affiliation></author><author role="aut"><persName><forename type="first">Claire</forename><surname>Ewenczyk</surname></persName><email></email><idno type="halauthor">536742</idno><affiliation ref="#struct-41019"></affiliation></author><author role="aut"><persName><forename type="first">Maria-Clara</forename><surname>Coelho-Braga</surname></persName><email></email><idno type="halauthor">536743</idno><affiliation ref="#struct-14242"></affiliation></author><author role="aut"><persName><forename type="first">Christelle</forename><surname>Lagrange</surname></persName><email></email><idno type="halauthor">403201</idno><affiliation ref="#struct-14242"></affiliation></author><author role="aut"><persName><forename type="first">Valerie</forename><surname>Fraix</surname></persName><email></email><idno type="halauthor">410234</idno><affiliation ref="#struct-14242"></affiliation></author><author role="aut"><persName><forename type="first">Philippe</forename><surname>Cornu</surname></persName><email></email><idno type="halauthor">385265</idno><affiliation ref="#struct-41019"></affiliation></author><author role="aut"><persName><forename type="first">Alim-Louis</forename><surname>Benabid</surname></persName><email></email><idno type="halauthor">296407</idno><affiliation ref="#struct-92131"></affiliation></author><author role="aut"><persName><forename type="first">Marie</forename><surname>Vidailhet</surname></persName><email></email><idno type="halauthor">216232</idno><affiliation ref="#struct-41019"></affiliation><affiliation ref="#struct-3037"></affiliation></author><author role="aut"><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><email></email><idno type="halauthor">233619</idno><affiliation ref="#struct-14242"></affiliation></author><editor role="depositor"><persName><forename>Marc</forename><surname>Savasta</surname></persName><email>marc.savasta@ujf-grenoble.fr</email></editor><funder>Direction Regionale de la Recherche Clinique Assistance - Publique - Hopitaux de Paris CRIC 2004</funder></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2010-10-25 10:55:46</date><date type="whenModified">2010-10-25 16:43:27</date><date type="whenReleased">2010-10-25 16:43:27</date><date type="whenProduced">2009-12-15</date></edition><respStmt><resp>contributor</resp><name key="140382"><persName><forename>Marc</forename><surname>Savasta</surname></persName><email>marc.savasta@ujf-grenoble.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00529166</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00529166</idno><idno type="halBibtex">grabli:inserm-00529166</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2009, 24 (16), pp.2363-9. <10.1002/mds.22827></idno><idno type="halRef">Movement Disorders, Wiley, 2009, 24 (16), pp.2363-9. <10.1002/mds.22827></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno><idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno><idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno><idno type="stamp" n="UGA">HAL Grenoble Alpes</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interruption of deep brain stimulation of the globus pallidus in primary generalized dystonia.</title><author role="crp"><persName><forename type="first">David</forename><surname>Grabli</surname></persName><email>david.grabli@psl.aphp.fr</email><idno type="halAuthorId">536741</idno><affiliation ref="#struct-41019"></affiliation><affiliation ref="#struct-3037"></affiliation></author><author role="aut"><persName><forename type="first">Claire</forename><surname>Ewenczyk</surname></persName><idno type="halAuthorId">536742</idno><affiliation ref="#struct-41019"></affiliation></author><author role="aut"><persName><forename type="first">Maria-Clara</forename><surname>Coelho-Braga</surname></persName><idno type="halAuthorId">536743</idno><affiliation ref="#struct-14242"></affiliation></author><author role="aut"><persName><forename type="first">Christelle</forename><surname>Lagrange</surname></persName><idno type="halAuthorId">403201</idno><affiliation ref="#struct-14242"></affiliation></author><author role="aut"><persName><forename type="first">Valerie</forename><surname>Fraix</surname></persName><idno type="halAuthorId">410234</idno><affiliation ref="#struct-14242"></affiliation></author><author role="aut"><persName><forename type="first">Philippe</forename><surname>Cornu</surname></persName><idno type="halAuthorId">385265</idno><affiliation ref="#struct-41019"></affiliation></author><author role="aut"><persName><forename type="first">Alim-Louis</forename><surname>Benabid</surname></persName><idno type="halAuthorId">296407</idno><affiliation ref="#struct-92131"></affiliation></author><author role="aut"><persName><forename type="first">Marie</forename><surname>Vidailhet</surname></persName><idno type="halAuthorId">216232</idno><affiliation ref="#struct-41019"></affiliation><affiliation ref="#struct-3037"></affiliation></author><author role="aut"><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><idno type="halAuthorId">233619</idno><affiliation ref="#struct-14242"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">24</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="pp">2363-9</biblScope><date type="datePub">2009-12-15</date></imprint></monogr><idno type="doi">10.1002/mds.22827</idno><idno type="pubmed">19908309</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="mesh">Adult</classCode><classCode scheme="mesh">Deep Brain Stimulation</classCode><classCode scheme="mesh">Severity of Illness Index</classCode><classCode scheme="mesh">Time Factors</classCode><classCode scheme="mesh">Young Adult</classCode><classCode scheme="mesh">Disability Evaluation</classCode><classCode scheme="mesh">Double-Blind Method</classCode><classCode scheme="mesh">Dystonia</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Globus Pallidus</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">Stimulation (DBS) of the globus pallidus (GP) is effective to treat generalized dystonia. Little is known about the evolution of dystonia in case of arrest after a long period of stimulation. This study describes the course of dystonia during a 48 hours period without stimulation followed by a 24 hours period after turning ON the stimulator. 14 patients with generalized dystonia treated with bilateral GP DBS for 3 years or more were recruited. Blinded video-based analysis was performed using Burke-Fahn-Marsden scale at (1) baseline (ON stimulation), (2) up to 48 hours after the stimulator was turned OFF, and (3) 24 hours after the stimulator was turned ON. 13 patients completed the 48 hours OFF-stimulation period. The dystonia movement score progressively worsened from 24.3 +/- 13.9 at baseline to 48.9 +/- 19.8 after 48 hours (P < 0.00001). The disability score also worsened from 4.4 +/- 1.2 at baseline to 5.7 +/- 1.5 after 48 hours without stimulation (P < 0.001). When the neurostimulator was turned ON, the dystonia scores returned to baseline level after 10 hours. The interruption of GP DBS in dystonia results in a progressive worsening which is rapidly reversible once the neurostimulator is turned ON.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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