Microsubthalamotomy effect at day 3: screening for determinants.
Identifieur interne : 000042 ( Hal/Corpus ); précédent : 000041; suivant : 000043Microsubthalamotomy effect at day 3: screening for determinants.
Auteurs : David Maltête ; Nathalie Chastan ; Stéphane Derrey ; Bertrand Debono ; Emmanuel Gérardin ; Romain Lefaucheur ; Bruno Mihout ; Didier HannequinSource :
- Movement Disorders [ 0885-3185 ] ; 2009-01-30.
Abstract
A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post-traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures.
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DOI: 10.1002/mds.22380
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Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-43394" status="VALID"><orgName>Service de neurologie [Rouen]</orgName><desc><address><country key="FR"></country></address></desc><listRelation><relation active="#struct-300147" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1002/mds.22380</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2009-01-30</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post-traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Microsubthalamotomy effect at day 3: screening for determinants.</title><author role="aut"><persName><forename type="first">David</forename><surname>Maltête</surname></persName><email></email><idno type="halauthor">214479</idno><affiliation ref="#struct-43394"></affiliation><affiliation ref="#struct-2972"></affiliation></author><author role="aut"><persName><forename type="first">Nathalie</forename><surname>Chastan</surname></persName><email></email><idno type="halauthor">479008</idno><affiliation ref="#struct-115097"></affiliation></author><author role="aut"><persName><forename type="first">Stéphane</forename><surname>Derrey</surname></persName><email></email><idno type="halauthor">478968</idno><affiliation ref="#struct-111551"></affiliation></author><author role="aut"><persName><forename type="first">Bertrand</forename><surname>Debono</surname></persName><email></email><idno type="halauthor">479009</idno><affiliation ref="#struct-111551"></affiliation></author><author role="aut"><persName><forename type="first">Emmanuel</forename><surname>Gérardin</surname></persName><email></email><idno type="halauthor">348290</idno><affiliation ref="#struct-110330"></affiliation></author><author role="aut"><persName><forename type="first">Romain</forename><surname>Lefaucheur</surname></persName><email></email><idno type="halauthor">479010</idno><affiliation ref="#struct-43394"></affiliation></author><author role="aut"><persName><forename type="first">Bruno</forename><surname>Mihout</surname></persName><email></email><idno type="halauthor">475908</idno><affiliation ref="#struct-43394"></affiliation></author><author role="aut"><persName><forename type="first">Didier</forename><surname>Hannequin</surname></persName><email></email><idno type="halauthor">270912</idno><affiliation ref="#struct-43394"></affiliation><affiliation ref="#struct-2972"></affiliation></author><editor role="depositor"><persName><forename>Céline</forename><surname>Breton</surname></persName><email>celine.breton@chb.unicancer.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2010-04-13 11:42:15</date><date type="whenModified">2010-05-03 09:47:51</date><date type="whenReleased">2010-04-29 11:44:31</date><date type="whenProduced">2009-01-30</date></edition><respStmt><resp>contributor</resp><name key="147030"><persName><forename>Céline</forename><surname>Breton</surname></persName><email>celine.breton@chb.unicancer.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00472800</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00472800</idno><idno type="halBibtex">maltete:inserm-00472800</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2009, 24 (2), pp.286-9. <10.1002/mds.22380></idno><idno type="halRef">Movement Disorders, Wiley, 2009, 24 (2), pp.286-9. <10.1002/mds.22380></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="UNIV-ROUEN">Université de Rouen</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Microsubthalamotomy effect at day 3: screening for determinants.</title><author role="aut"><persName><forename type="first">David</forename><surname>Maltête</surname></persName><idno type="halAuthorId">214479</idno><affiliation ref="#struct-43394"></affiliation><affiliation ref="#struct-2972"></affiliation></author><author role="aut"><persName><forename type="first">Nathalie</forename><surname>Chastan</surname></persName><idno type="halAuthorId">479008</idno><affiliation ref="#struct-115097"></affiliation></author><author role="aut"><persName><forename type="first">Stéphane</forename><surname>Derrey</surname></persName><idno type="halAuthorId">478968</idno><affiliation ref="#struct-111551"></affiliation></author><author role="aut"><persName><forename type="first">Bertrand</forename><surname>Debono</surname></persName><idno type="halAuthorId">479009</idno><affiliation ref="#struct-111551"></affiliation></author><author role="aut"><persName><forename type="first">Emmanuel</forename><surname>Gérardin</surname></persName><idno type="halAuthorId">348290</idno><affiliation ref="#struct-110330"></affiliation></author><author role="aut"><persName><forename type="first">Romain</forename><surname>Lefaucheur</surname></persName><idno type="halAuthorId">479010</idno><affiliation ref="#struct-43394"></affiliation></author><author role="aut"><persName><forename type="first">Bruno</forename><surname>Mihout</surname></persName><idno type="halAuthorId">475908</idno><affiliation ref="#struct-43394"></affiliation></author><author role="aut"><persName><forename type="first">Didier</forename><surname>Hannequin</surname></persName><idno type="halAuthorId">270912</idno><affiliation ref="#struct-43394"></affiliation><affiliation ref="#struct-2972"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="pp">286-9</biblScope><date type="datePub">2009-01-30</date></imprint></monogr><idno type="doi">10.1002/mds.22380</idno><idno type="pubmed">19170190</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="mesh">Adolescent</classCode><classCode scheme="mesh">Adult</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="mesh">Hypokinesia</classCode><classCode scheme="mesh">Magnetic Resonance Imaging</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="mesh">Muscle Rigidity</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="mesh">Postoperative Period</classCode><classCode scheme="mesh">Radiography, Interventional</classCode><classCode scheme="mesh">Severity of Illness Index</classCode><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Stereotaxic Techniques</classCode><classCode scheme="mesh">Thalamus</classCode><classCode scheme="mesh">Time Factors</classCode><classCode scheme="mesh">Tomography, X-Ray Computed</classCode><classCode scheme="mesh">Tremor</classCode><classCode scheme="mesh">Antiparkinson Agents</classCode><classCode scheme="mesh">Brain Edema</classCode><classCode scheme="mesh">Combined Modality Therapy</classCode><classCode scheme="mesh">Contrast Media</classCode><classCode scheme="mesh">Deep Brain Stimulation</classCode><classCode scheme="mesh">Dyskinesias</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post-traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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