Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia.
Identifieur interne : 000032 ( Hal/Corpus ); précédent : 000031; suivant : 000033Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia.
Auteurs : George Lourenço ; Sabine Meunier ; Marie Vidailhet ; Marion Simonetta-MoreauSource :
- Movement Disorders [ 0885-3185 ] ; 2007-03-15.
Abstract
A decrease of heteronymous median nerve-evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median-induced) but also homonymous (radial-induced) inhibitions (interstimuli intervals 13-21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median-induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial-induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles.
Url:
DOI: 10.1002/mds.21312
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Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median-induced) but also homonymous (radial-induced) inhibitions (interstimuli intervals 13-21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median-induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial-induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia.</title><author role="aut"><persName><forename type="first">George</forename><surname>Lourenço</surname></persName><email></email><idno type="halauthor">216203</idno><affiliation ref="#struct-3089"></affiliation></author><author role="aut"><persName><forename type="first">Sabine</forename><surname>Meunier</surname></persName><email></email><idno type="halauthor">116381</idno><affiliation ref="#struct-3089"></affiliation></author><author role="aut"><persName><forename type="first">Marie</forename><surname>Vidailhet</surname></persName><email></email><idno type="halauthor">216232</idno><affiliation ref="#struct-16622"></affiliation><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-18479"></affiliation></author><author role="aut"><persName><forename type="first">Marion</forename><surname>Simonetta-Moreau</surname></persName><email></email><idno type="halauthor">216230</idno></author><editor role="depositor"><persName><forename>Genevieve</forename><surname>Bard</surname></persName><email>genevieve.bard@chups.jussieu.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2008-04-11 14:12:25</date><date type="whenModified">2008-04-11 14:12:25</date><date type="whenReleased">2008-04-11 14:12:25</date><date type="whenProduced">2007-03-15</date></edition><respStmt><resp>contributor</resp><name key="121393"><persName><forename>Genevieve</forename><surname>Bard</surname></persName><email>genevieve.bard@chups.jussieu.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-00272387</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00272387</idno><idno type="halBibtex">lourenco:hal-00272387</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2007, 22 (4), pp.523-7. <10.1002/mds.21312></idno><idno type="halRef">Movement Disorders, Wiley, 2007, 22 (4), pp.523-7. <10.1002/mds.21312></idno></publicationStmt><seriesStmt><idno type="stamp" n="APHP" p="INSERM">AP-HP</idno><idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno><idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia.</title><author role="aut"><persName><forename type="first">George</forename><surname>Lourenço</surname></persName><idno type="halAuthorId">216203</idno><affiliation ref="#struct-3089"></affiliation></author><author role="aut"><persName><forename type="first">Sabine</forename><surname>Meunier</surname></persName><idno type="halAuthorId">116381</idno><affiliation ref="#struct-3089"></affiliation></author><author role="aut"><persName><forename type="first">Marie</forename><surname>Vidailhet</surname></persName><idno type="halAuthorId">216232</idno><affiliation ref="#struct-16622"></affiliation><affiliation ref="#struct-3037"></affiliation><affiliation ref="#struct-18479"></affiliation></author><author role="aut"><persName><forename type="first">Marion</forename><surname>Simonetta-Moreau</surname></persName><idno type="halAuthorId">216230</idno></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">22</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="pp">523-7</biblScope><date type="datePub">2007-03-15</date></imprint></monogr><idno type="doi">10.1002/mds.21312</idno><idno type="pubmed">17230472</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="mesh">Adolescent</classCode><classCode scheme="mesh">Adult</classCode><classCode scheme="mesh">Magnetics</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Middle Aged</classCode><classCode scheme="mesh">Motor Cortex</classCode><classCode scheme="mesh">Muscle, Skeletal</classCode><classCode scheme="mesh">Neurons, Afferent</classCode><classCode scheme="mesh">Posture</classCode><classCode scheme="mesh">Transcranial Magnetic Stimulation</classCode><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Dystonia</classCode><classCode scheme="mesh">Dystonic Disorders</classCode><classCode scheme="mesh">Electromyography</classCode><classCode scheme="mesh">Evoked Potentials, Motor</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Hand</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="halDomain" n="sdv.ba.mvsa">Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">A decrease of heteronymous median nerve-evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median-induced) but also homonymous (radial-induced) inhibitions (interstimuli intervals 13-21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median-induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial-induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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