Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study.
Identifieur interne : 000063 ( Hal/Checkpoint ); précédent : 000062; suivant : 000064Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study.
Auteurs : Alexis Elbaz [France] ; Brett Peterson [États-Unis] ; Ping Yang [États-Unis] ; James Bower [États-Unis] ; Demetrius Maraganore [États-Unis] ; Shannon Mcdonnell [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Walter Rocca [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-06.
English descriptors
Abstract
We investigated the risk of cancer after the diagnosis of Parkinson's disease (PD) through a historical cohort study. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, Minnesota from 1976 through 1995. Patients with PD were matched by age (+/- 1 year) and gender to referent subjects from the same population. For 196 patients and 185 referent subjects, we ascertained the incidence of cancer through medical records abstraction between the date of diagnosis (or index date) and death, loss to follow-up, or end of study. The risk of cancer was higher among patients than in referent subjects (relative risk [RR] = 1.64; 95% confidence interval [CI] = 1.15-2.35; P = 0.007). The RR did not change noticeably after adjustment for smoking. The increased risk was significant for nonmelanoma skin cancer (RR = 1.76; 95% CI = 1.07-2.89; P = 0.03), but not for other more severe types of cancer; therefore, we cannot exclude the occurrence of a surveillance bias. Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications.
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DOI: 10.1002/mds.20401
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Eric" last="Ahlskog">J. Eric Ahlskog</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-45572" status="INCOMING"><orgName>Department of Neurology</orgName><desc><address><country key="US"></country></address></desc><listRelation><relation active="#struct-310852" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310852" type="direct"><org type="institution" xml:id="struct-310852" status="INCOMING"><orgName>Mayo Clinic College of Medicine, Rochester, Minnesota, USA</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author><author><name sortKey="Rocca, Walter" sort="Rocca, Walter" uniqKey="Rocca W" first="Walter" last="Rocca">Walter Rocca</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-94149" status="VALID"><orgName>Department of Health Sciences Research [Mayo Clinic]</orgName><orgName type="acronym">HSR</orgName><desc><address><addrLine>Mayo Clinic 200 First Street SW Rochester, MN 55905 USA</addrLine><country key="US"></country></address><ref type="url">http://mayoresearch.mayo.edu/hsr/index.cfm</ref></desc><listRelation><relation active="#struct-310910" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310910" type="direct"><org type="institution" xml:id="struct-310910" status="VALID"><orgName>Mayo Clinic</orgName><desc><address><country key="US"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>États-Unis</country></affiliation></author></analytic><idno type="DOI">10.1002/mds.20401</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2005-06</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Parkinson's disease</term><term>cancer</term><term>cohort study</term><term>etiology</term><term>risk factors</term><term>skin cancer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the risk of cancer after the diagnosis of Parkinson's disease (PD) through a historical cohort study. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, Minnesota from 1976 through 1995. Patients with PD were matched by age (+/- 1 year) and gender to referent subjects from the same population. For 196 patients and 185 referent subjects, we ascertained the incidence of cancer through medical records abstraction between the date of diagnosis (or index date) and death, loss to follow-up, or end of study. The risk of cancer was higher among patients than in referent subjects (relative risk [RR] = 1.64; 95% confidence interval [CI] = 1.15-2.35; P = 0.007). The RR did not change noticeably after adjustment for smoking. The increased risk was significant for nonmelanoma skin cancer (RR = 1.76; 95% CI = 1.07-2.89; P = 0.03), but not for other more severe types of cancer; therefore, we cannot exclude the occurrence of a surveillance bias. Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study.</title><author role="aut"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><email>elbaz@chups.jussieu.fr</email><idno type="halauthor">214201</idno><affiliation ref="#struct-3066"></affiliation><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">Brett</forename><forename type="middle">J.</forename><surname>Peterson</surname></persName><email></email><idno type="halauthor">214214</idno><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">Ping</forename><surname>Yang</surname></persName><email></email><idno type="halauthor">214215</idno><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">James</forename><forename type="middle">H.</forename><surname>Bower</surname></persName><email></email><idno type="halauthor">214216</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">Demetrius</forename><forename type="middle">M.</forename><surname>Maraganore</surname></persName><email></email><idno type="halauthor">214217</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">Shannon</forename><forename type="middle">K.</forename><surname>Mcdonnell</surname></persName><email></email><idno type="halauthor">214218</idno><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">J. Eric</forename><surname>Ahlskog</surname></persName><email></email><idno type="halauthor">214219</idno><affiliation ref="#struct-45572"></affiliation></author><author role="crp"><persName><forename type="first">Walter</forename><forename type="middle">A.</forename><surname>Rocca</surname></persName><email>rocca@mayo.edu</email><idno type="halauthor">214220</idno><affiliation ref="#struct-94149"></affiliation><affiliation ref="#struct-45572"></affiliation></author><editor role="depositor"><persName><forename>Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2007-10-05 12:12:53</date><date type="whenModified">2015-01-19 11:49:49</date><date type="whenReleased">2007-10-05 13:44:18</date><date type="whenProduced">2005-06</date><date type="whenEndEmbargoed">9999-12-31</date><ref type="file" target="http://www.hal.inserm.fr/inserm-00177062/document"><date notBefore="9999-12-31"></date></ref><ref type="file" n="1" target="http://www.hal.inserm.fr/inserm-00177062/file/2.pdf"><date notBefore="9999-12-31"></date></ref></edition><respStmt><resp>contributor</resp><name key="118702"><persName><forename>Christophe</forename><surname>Tzourio</surname></persName><email>tzourio@chups.jussieu.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00177062</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00177062</idno><idno type="halBibtex">elbaz:inserm-00177062</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2005, 20 (6), pp.719-25. <10.1002/mds.20401></idno><idno type="halRef">Movement Disorders, Wiley, 2005, 20 (6), pp.719-25. <10.1002/mds.20401></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno><idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study.</title><author role="aut"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><email>elbaz@chups.jussieu.fr</email><idno type="halAuthorId">214201</idno><affiliation ref="#struct-3066"></affiliation><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">Brett</forename><forename type="middle">J.</forename><surname>Peterson</surname></persName><idno type="halAuthorId">214214</idno><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">Ping</forename><surname>Yang</surname></persName><idno type="halAuthorId">214215</idno><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">James</forename><forename type="middle">H.</forename><surname>Bower</surname></persName><idno type="halAuthorId">214216</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">Demetrius</forename><forename type="middle">M.</forename><surname>Maraganore</surname></persName><idno type="halAuthorId">214217</idno><affiliation ref="#struct-45572"></affiliation></author><author role="aut"><persName><forename type="first">Shannon</forename><forename type="middle">K.</forename><surname>Mcdonnell</surname></persName><idno type="halAuthorId">214218</idno><affiliation ref="#struct-94149"></affiliation></author><author role="aut"><persName><forename type="first">J. Eric</forename><surname>Ahlskog</surname></persName><idno type="halAuthorId">214219</idno><affiliation ref="#struct-45572"></affiliation></author><author role="crp"><persName><forename type="first">Walter</forename><forename type="middle">A.</forename><surname>Rocca</surname></persName><email>rocca@mayo.edu</email><idno type="halAuthorId">214220</idno><affiliation ref="#struct-94149"></affiliation><affiliation ref="#struct-45572"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">20</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="pp">719-25</biblScope><date type="datePub">2005-06</date></imprint></monogr><idno type="doi">10.1002/mds.20401</idno><idno type="pubmed">15704188</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><keywords scheme="author"><term xml:lang="en">Parkinson's disease</term><term xml:lang="en">cancer</term><term xml:lang="en">skin cancer</term><term xml:lang="en">risk factors</term><term xml:lang="en">etiology</term><term xml:lang="en">cohort study</term></keywords><classCode scheme="mesh">Aged</classCode><classCode scheme="mesh">Aged, 80 and over</classCode><classCode scheme="mesh">Male</classCode><classCode scheme="mesh">Neoplasms</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="mesh">Reference Values</classCode><classCode scheme="mesh">Retrospective Studies</classCode><classCode scheme="mesh">Risk</classCode><classCode scheme="mesh">Antiparkinson Agents</classCode><classCode scheme="mesh">Case-Control Studies</classCode><classCode scheme="mesh">Cohort Studies</classCode><classCode scheme="mesh">Confidence Intervals</classCode><classCode scheme="mesh">Demography</classCode><classCode scheme="mesh">Female</classCode><classCode scheme="mesh">Follow-Up Studies</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode><classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">We investigated the risk of cancer after the diagnosis of Parkinson's disease (PD) through a historical cohort study. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, Minnesota from 1976 through 1995. Patients with PD were matched by age (+/- 1 year) and gender to referent subjects from the same population. For 196 patients and 185 referent subjects, we ascertained the incidence of cancer through medical records abstraction between the date of diagnosis (or index date) and death, loss to follow-up, or end of study. The risk of cancer was higher among patients than in referent subjects (relative risk [RR] = 1.64; 95% confidence interval [CI] = 1.15-2.35; P = 0.007). The RR did not change noticeably after adjustment for smoking. The increased risk was significant for nonmelanoma skin cancer (RR = 1.76; 95% CI = 1.07-2.89; P = 0.03), but not for other more severe types of cancer; therefore, we cannot exclude the occurrence of a surveillance bias. Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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