Deep brain stimulation effect on freezing of gait.
Identifieur interne : 000041 ( Hal/Checkpoint ); précédent : 000040; suivant : 000042Deep brain stimulation effect on freezing of gait.
Auteurs : Murielle Ferraye [France] ; Bettina Debû [France] ; Pierre Pollak [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008.
Abstract
The majority of patients with Parkinson's disease suffer from freezing of gait (FOG), which responds more or less to levodopa. Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa-responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa-resistant FOG. In the few cases of levodopa-induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off- and on-levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients.
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DOI: 10.1002/mds.21975
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Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa-responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa-resistant FOG. In the few cases of levodopa-induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off- and on-levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Deep brain stimulation effect on freezing of gait.</title><author role="aut"><persName><forename type="first">Murielle</forename><forename type="middle">U.</forename><surname>Ferraye</surname></persName><email></email><idno type="halauthor">410261</idno><affiliation ref="#struct-86972"></affiliation></author><author role="aut"><persName><forename type="first">Bettina</forename><surname>Debû</surname></persName><email></email><idno type="halauthor">407445</idno><affiliation ref="#struct-86972"></affiliation></author><author role="aut"><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><email></email><idno type="halauthor">233619</idno><affiliation ref="#struct-86972"></affiliation></author><editor role="depositor"><persName><forename>Marc</forename><surname>Savasta</surname></persName><email>marc.savasta@ujf-grenoble.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2009-06-04 09:56:43</date><date type="whenModified">2009-06-12 14:54:51</date><date type="whenReleased">2009-06-12 14:54:51</date><date type="whenProduced">2008</date></edition><respStmt><resp>contributor</resp><name key="140382"><persName><forename>Marc</forename><surname>Savasta</surname></persName><email>marc.savasta@ujf-grenoble.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inserm-00391463</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00391463</idno><idno type="halBibtex">ferraye:inserm-00391463</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2008, 23 Suppl 2, pp.S489-94. <10.1002/mds.21975></idno><idno type="halRef">Movement Disorders, Wiley, 2008, 23 Suppl 2, pp.S489-94. <10.1002/mds.21975></idno></publicationStmt><seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno><idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno><idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno><idno type="stamp" n="UGA">HAL Grenoble Alpes</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation effect on freezing of gait.</title><author role="aut"><persName><forename type="first">Murielle</forename><forename type="middle">U.</forename><surname>Ferraye</surname></persName><idno type="halAuthorId">410261</idno><affiliation ref="#struct-86972"></affiliation></author><author role="aut"><persName><forename type="first">Bettina</forename><surname>Debû</surname></persName><idno type="halAuthorId">407445</idno><affiliation ref="#struct-86972"></affiliation></author><author role="aut"><persName><forename type="first">Pierre</forename><surname>Pollak</surname></persName><idno type="halAuthorId">233619</idno><affiliation ref="#struct-86972"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">23 Suppl 2</biblScope><biblScope unit="pp">S489-94</biblScope><date type="datePub">2008</date></imprint></monogr><idno type="doi">10.1002/mds.21975</idno><idno type="pubmed">18668617</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="mesh">Deep Brain Stimulation</classCode><classCode scheme="mesh">Freezing Reaction, Cataleptic</classCode><classCode scheme="mesh">Gait</classCode><classCode scheme="mesh">Gait Disorders, Neurologic</classCode><classCode scheme="mesh">Humans</classCode><classCode scheme="mesh">Parkinson Disease</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">The majority of patients with Parkinson's disease suffer from freezing of gait (FOG), which responds more or less to levodopa. Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa-responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa-resistant FOG. In the few cases of levodopa-induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off- and on-levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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