Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation.
Identifieur interne : 000022 ( Hal/Checkpoint ); précédent : 000021; suivant : 000023Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation.
Auteurs : Tiphaine Rouaud [France] ; Thibaut Dondaine [France] ; Sophie Drapier [France] ; Claire Haegelen [France] ; François Lallement ; Julie Péron ; Sylvie Raoul ; Paul Sauleau [France] ; Marc Vérin [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
Abstract
The aim of this study was to evaluate the efficacy and safety of bilateral pallidal (GPi) deep brain stimulation (DBS) 6 months after surgery in advanced parkinsonian patients whose dopa-resistant axial motor signs or cognitive decline constituted contraindications for subthalamic nucleus (STN) DBS. Seventeen patients with a mean age of 59.3 ± 7.1 years (range, 45-70), mean disease duration of 12.5 ± 4.3 years (range, 7-20), and contraindications for STN DBS, underwent bilateral GPi DBS. They were evaluated before surgery and 6 months afterward, in accordance with Core Assessment Program for Intracerebral Transplantation recommendations. There were mean improvements of 41.1% in the UPDRS III motor score in the off-dopa condition and 20.3% in the activities of daily living score. Motor fluctuations were reduced by 22.9% and dyskinesias by 68.6%. Axial motor signs improved in the off-dopa condition by 34.2%. Neuropsychological performances remained unchanged at the 6-month assessment. Bilateral GPi DBS is both safe and effective in advanced parkinsonian patients with untreatable motor fluctuations, for whom STN DBS is contraindicated due to dopa-resistant axial motor signs or cognitive decline. As such, it should be regarded as a viable option for these patients.
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DOI: 10.1002/mds.23171
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CS 46510 - 35065 Rennes cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rennes1.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author><author><name sortKey="Dondaine, Thibaut" sort="Dondaine, Thibaut" uniqKey="Dondaine T" first="Thibaut" last="Dondaine">Thibaut Dondaine</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-238036" status="VALID"><orgName>Comportement et noyaux gris centraux [Rennes]</orgName><desc><address><addrLine>1, rue Anatole Le Braz - 35700 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://incr.fr/recherche/23-ea-4712-comportements-et-noyaux-gris-centraux</ref></desc><listRelation><relation name="EA4712" active="#struct-105160" type="direct"></relation><relation active="#struct-108091" type="direct"></relation><relation active="#struct-301327" type="direct"></relation><relation active="#struct-357205" type="direct"></relation></listRelation><tutelles><tutelle name="EA4712" active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"><orgName>Université de Rennes 1</orgName><orgName type="acronym">UR1</orgName><desc><address><addrLine>2 rue du Thabor - 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CS 46510 - 35065 Rennes cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rennes1.fr/</ref></desc></org></tutelle><tutelle active="#struct-300129" type="direct"><org type="institution" xml:id="struct-300129" status="VALID"><orgName>Hôpital Pontchaillou</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-301327" type="direct"><org type="institution" xml:id="struct-301327" status="VALID"><orgName>Centre hospitalier universitaire [Rennes]</orgName><orgName type="acronym">CHU</orgName><desc><address><addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine><country key="FR"></country></address><ref type="url">http://www.chu-rennes.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author></analytic><idno type="DOI">10.1002/mds.23171</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2010-09-15</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the efficacy and safety of bilateral pallidal (GPi) deep brain stimulation (DBS) 6 months after surgery in advanced parkinsonian patients whose dopa-resistant axial motor signs or cognitive decline constituted contraindications for subthalamic nucleus (STN) DBS. Seventeen patients with a mean age of 59.3 ± 7.1 years (range, 45-70), mean disease duration of 12.5 ± 4.3 years (range, 7-20), and contraindications for STN DBS, underwent bilateral GPi DBS. They were evaluated before surgery and 6 months afterward, in accordance with Core Assessment Program for Intracerebral Transplantation recommendations. There were mean improvements of 41.1% in the UPDRS III motor score in the off-dopa condition and 20.3% in the activities of daily living score. Motor fluctuations were reduced by 22.9% and dyskinesias by 68.6%. Axial motor signs improved in the off-dopa condition by 34.2%. Neuropsychological performances remained unchanged at the 6-month assessment. Bilateral GPi DBS is both safe and effective in advanced parkinsonian patients with untreatable motor fluctuations, for whom STN DBS is contraindicated due to dopa-resistant axial motor signs or cognitive decline. As such, it should be regarded as a viable option for these patients.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation.</title><author role="aut"><persName><forename type="first">Tiphaine</forename><surname>Rouaud</surname></persName><email></email><idno type="halauthor">818765</idno><affiliation ref="#struct-33545"></affiliation></author><author role="aut"><persName><forename type="first">Thibaut</forename><surname>Dondaine</surname></persName><email></email><idno type="halauthor">740415</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Sophie</forename><surname>Drapier</surname></persName><email></email><idno type="halauthor">773331</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Claire</forename><surname>Haegelen</surname></persName><email></email><idno type="halauthor">169922</idno><affiliation ref="#struct-33417"></affiliation></author><author role="aut"><persName><forename type="first">François</forename><surname>Lallement</surname></persName><email></email><idno type="halauthor">1147161</idno></author><author role="aut"><persName><forename type="first">Julie</forename><surname>Péron</surname></persName><email></email><idno type="halauthor">646118</idno></author><author role="aut"><persName><forename type="first">Sylvie</forename><surname>Raoul</surname></persName><email></email><idno type="halauthor">216271</idno></author><author role="aut"><persName><forename type="first">Paul</forename><surname>Sauleau</surname></persName><email></email><idno type="halauthor">296413</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Marc</forename><surname>Vérin</surname></persName><email></email><idno type="halauthor">362876</idno><affiliation ref="#struct-155115"></affiliation><affiliation ref="#struct-238036"></affiliation></author><editor role="depositor"><persName><forename>Laurent</forename><surname>Jonchère</surname></persName><email>laurent.jonchere@univ-rennes1.fr</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2015-03-20 16:04:01</date><date type="whenModified">2015-03-21 01:03:51</date><date type="whenReleased">2015-03-20 16:04:01</date><date type="whenProduced">2010-09-15</date></edition><respStmt><resp>contributor</resp><name key="113861"><persName><forename>Laurent</forename><surname>Jonchère</surname></persName><email>laurent.jonchere@univ-rennes1.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-01133911</idno><idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133911</idno><idno type="halBibtex">rouaud:hal-01133911</idno><idno type="halRefHtml">Movement Disorders, Wiley, 2010, 25 (12), pp.1839-46. <10.1002/mds.23171></idno><idno type="halRef">Movement Disorders, Wiley, 2010, 25 (12), pp.1839-46. <10.1002/mds.23171></idno></publicationStmt><seriesStmt><idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno><idno type="stamp" n="CNGC">Comportement et noyaux gris centraux EA4712</idno><idno type="stamp" n="HL">Publications CHU - Rennes 1</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pallidal stimulation in advanced Parkinson's patients with contraindications for subthalamic stimulation.</title><author role="aut"><persName><forename type="first">Tiphaine</forename><surname>Rouaud</surname></persName><idno type="halAuthorId">818765</idno><affiliation ref="#struct-33545"></affiliation></author><author role="aut"><persName><forename type="first">Thibaut</forename><surname>Dondaine</surname></persName><idno type="halAuthorId">740415</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Sophie</forename><surname>Drapier</surname></persName><idno type="halAuthorId">773331</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Claire</forename><surname>Haegelen</surname></persName><idno type="halAuthorId">169922</idno><affiliation ref="#struct-33417"></affiliation></author><author role="aut"><persName><forename type="first">François</forename><surname>Lallement</surname></persName><idno type="halAuthorId">1147161</idno></author><author role="aut"><persName><forename type="first">Julie</forename><surname>Péron</surname></persName><idno type="halAuthorId">646118</idno></author><author role="aut"><persName><forename type="first">Sylvie</forename><surname>Raoul</surname></persName><idno type="halAuthorId">216271</idno></author><author role="aut"><persName><forename type="first">Paul</forename><surname>Sauleau</surname></persName><idno type="halAuthorId">296413</idno><affiliation ref="#struct-238036"></affiliation></author><author role="aut"><persName><forename type="first">Marc</forename><surname>Vérin</surname></persName><idno type="halAuthorId">362876</idno><affiliation ref="#struct-155115"></affiliation><affiliation ref="#struct-238036"></affiliation></author></analytic><monogr><idno type="halJournalId" status="VALID">17211</idno><idno type="issn">0885-3185</idno><idno type="eissn">1531-8257</idno><title level="j">Movement Disorders</title><imprint><publisher>Wiley</publisher><biblScope unit="volume">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="pp">1839-46</biblScope><date type="datePub">2010-09-15</date></imprint></monogr><idno type="doi">10.1002/mds.23171</idno><idno type="pubmed">20568094</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">The aim of this study was to evaluate the efficacy and safety of bilateral pallidal (GPi) deep brain stimulation (DBS) 6 months after surgery in advanced parkinsonian patients whose dopa-resistant axial motor signs or cognitive decline constituted contraindications for subthalamic nucleus (STN) DBS. Seventeen patients with a mean age of 59.3 ± 7.1 years (range, 45-70), mean disease duration of 12.5 ± 4.3 years (range, 7-20), and contraindications for STN DBS, underwent bilateral GPi DBS. They were evaluated before surgery and 6 months afterward, in accordance with Core Assessment Program for Intracerebral Transplantation recommendations. There were mean improvements of 41.1% in the UPDRS III motor score in the off-dopa condition and 20.3% in the activities of daily living score. Motor fluctuations were reduced by 22.9% and dyskinesias by 68.6%. Axial motor signs improved in the off-dopa condition by 34.2%. Neuropsychological performances remained unchanged at the 6-month assessment. Bilateral GPi DBS is both safe and effective in advanced parkinsonian patients with untreatable motor fluctuations, for whom STN DBS is contraindicated due to dopa-resistant axial motor signs or cognitive decline. As such, it should be regarded as a viable option for these patients.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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