Application of the International Cooperative Ataxia Scale rating in multiple system atrophy
Identifieur interne : 000496 ( France/Analysis ); précédent : 000495; suivant : 000497Application of the International Cooperative Ataxia Scale rating in multiple system atrophy
Auteurs : François Tison [France] ; Farid Yekhlef [France] ; Eric Balestre [France] ; Virginie Chrysostome [France] ; Niall Quinn [Royaume-Uni] ; Gregor K. Wenning [France] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Aged, Cerebellar Ataxia (diagnosis), Cross-Sectional Studies, Exploration, Female, France, Gait Disorders, Neurologic (diagnosis), Human, Humans, International Cooperative Ataxia Rating Scale, Male, Middle Aged, Multiple System Atrophy (diagnosis), Multiple system atrophy, Neurologic Examination (statistics & numerical data), Performance evaluation, Posture, Reproducibility of Results, cerebellum, multiple system atrophy.
- MESH :
- geographic : France.
- diagnosis : Cerebellar Ataxia, Gait Disorders, Neurologic, Multiple System Atrophy.
- statistics & numerical data : Neurologic Examination.
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Posture, Reproducibility of Results.
Abstract
We assessed the International Cooperative Ataxia Scale (ICARS) as a means of extracting and rating cerebellar signs in multiple system atrophy (MSA). Cross‐sectional analysis of internal consistency, factor structure, and correlation with parkinsonism severity (Unified Parkinson's Disease Rating Scale [UPDRS] III) of the ICARS, in 50 unselected MSA patients (mean age, 67.6 years; mean disease duration, 5.5 years), 50 age‐matched and disease duration‐matched Parkinson' disease (PD) patients, and 50 control subjects. Fifteen patients (30%) had MSA‐C (cerebellar subtype) and 35 (70%) MSA‐P (parkinsonism subtype), and 66% had at least one cerebellar sign. The total ICARS score was much higher (fivefold) in MSA compared to PD patients. The ICARS score was twofold higher in MSA‐C than in MSA‐P patients. MSA‐C patients had a higher score than MSA‐P mainly on posture and gait disturbances and kinetic functions subscores. All the ICARS items were significantly more severe in MSA than in PD patients, who in turn scored higher than the controls. In MSA, internal consistency was excellent (Cronbach = 0.93). Factor structure analysis revealed four clinically distinct subscores, in accordance with the scale structure, which accounted for 70% of the variance. The ICARS showed less consistency and accuracy in PD patients; however, the ICARS scores significantly correlated with the UPDRS‐III scores in both MSA and PD patients. The ICARS appears a useful tool to extract and rate the severity of cerebellar signs in MSA; however, it is clearly contaminated by parkinsonian features. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10290
Affiliations:
- Autriche, France, Royaume-Uni
- Angleterre, Grand Londres, Tyrol (Land)
- Bordeaux, Innsbruck, Londres
- Université de médecine d'Innsbruck
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ISTEX:746A070A05DB687D3E9BBA7172F498E379CB82CDLe document en format XML
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Cross‐sectional analysis of internal consistency, factor structure, and correlation with parkinsonism severity (Unified Parkinson's Disease Rating Scale [UPDRS] III) of the ICARS, in 50 unselected MSA patients (mean age, 67.6 years; mean disease duration, 5.5 years), 50 age‐matched and disease duration‐matched Parkinson' disease (PD) patients, and 50 control subjects. Fifteen patients (30%) had MSA‐C (cerebellar subtype) and 35 (70%) MSA‐P (parkinsonism subtype), and 66% had at least one cerebellar sign. The total ICARS score was much higher (fivefold) in MSA compared to PD patients. The ICARS score was twofold higher in MSA‐C than in MSA‐P patients. MSA‐C patients had a higher score than MSA‐P mainly on posture and gait disturbances and kinetic functions subscores. All the ICARS items were significantly more severe in MSA than in PD patients, who in turn scored higher than the controls. In MSA, internal consistency was excellent (Cronbach = 0.93). Factor structure analysis revealed four clinically distinct subscores, in accordance with the scale structure, which accounted for 70% of the variance. The ICARS showed less consistency and accuracy in PD patients; however, the ICARS scores significantly correlated with the UPDRS‐III scores in both MSA and PD patients. The ICARS appears a useful tool to extract and rate the severity of cerebellar signs in MSA; however, it is clearly contaminated by parkinsonian features. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Tyrol (Land)</li></region><settlement><li>Bordeaux</li><li>Innsbruck</li><li>Londres</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name></noRegion><name sortKey="Balestre, Eric" sort="Balestre, Eric" uniqKey="Balestre E" first="Eric" last="Balestre">Eric Balestre</name><name sortKey="Chrysostome, Virginie" sort="Chrysostome, Virginie" uniqKey="Chrysostome V" first="Virginie" last="Chrysostome">Virginie Chrysostome</name><name sortKey="Chrysostome, Virginie" sort="Chrysostome, Virginie" uniqKey="Chrysostome V" first="Virginie" last="Chrysostome">Virginie Chrysostome</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name></region></country><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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