[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].
Identifieur interne : 002987 ( PubMed/Curation ); précédent : 002986; suivant : 002988[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].
Auteurs : V V Vlasov ; V V Gorn ; N Iu Nomokonova ; T N Fokina ; L V IurchenkoSource :
- Molekuliarnaia biologiia [ 0026-8984 ]
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN viral (génétique), Animaux, Autoradiographie, Biosynthèse des protéines (), Données de séquences moléculaires, Lapins, Oligonucléotides antisens (pharmacologie), Protéines de la matrice virale (génétique), Séquence nucléotidique, Virus de la grippe A (métabolisme), Électrophorèse sur gel de polyacrylamide.
- MESH :
- génétique : ARN messager, ARN viral, Protéines de la matrice virale.
- métabolisme : Virus de la grippe A.
- pharmacologie : Oligonucléotides antisens.
- Animaux, Autoradiographie, Biosynthèse des protéines, Données de séquences moléculaires, Lapins, Séquence nucléotidique, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Autoradiography, Base Sequence, Electrophoresis, Polyacrylamide Gel, Influenza A virus (metabolism), Molecular Sequence Data, Oligonucleotides, Antisense (pharmacology), Protein Biosynthesis (drug effects), RNA, Messenger (genetics), RNA, Viral (genetics), Rabbits, Viral Matrix Proteins (genetics).
- MESH :
- chemical , genetics : RNA, Messenger, RNA, Viral, Viral Matrix Proteins.
- chemical , pharmacology : Oligonucleotides, Antisense.
- drug effects : Protein Biosynthesis.
- metabolism : Influenza A virus.
- Animals, Autoradiography, Base Sequence, Electrophoresis, Polyacrylamide Gel, Molecular Sequence Data, Rabbits.
Abstract
Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.
PubMed: 1753959
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pubmed:1753959Le document en format XML
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Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:1753959</idno><idno type="pmid">1753959</idno><idno type="wicri:Area/PubMed/Corpus">002987</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002987</idno><idno type="wicri:Area/PubMed/Curation">002987</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002987</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].</title><author><name sortKey="Vlasov, V V" sort="Vlasov, V V" uniqKey="Vlasov V" first="V V" last="Vlasov">V V Vlasov</name></author><author><name sortKey="Gorn, V V" sort="Gorn, V V" uniqKey="Gorn V" first="V V" last="Gorn">V V Gorn</name></author><author><name sortKey="Nomokonova, N Iu" sort="Nomokonova, N Iu" uniqKey="Nomokonova N" first="N Iu" last="Nomokonova">N Iu Nomokonova</name></author><author><name sortKey="Fokina, T N" sort="Fokina, T N" uniqKey="Fokina T" first="T N" last="Fokina">T N Fokina</name></author><author><name sortKey="Iurchenko, L V" sort="Iurchenko, L V" uniqKey="Iurchenko L" first="L V" last="Iurchenko">L V Iurchenko</name></author></analytic><series><title level="j">Molekuliarnaia biologiia</title><idno type="ISSN">0026-8984</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autoradiography</term><term>Base Sequence</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Influenza A virus (metabolism)</term><term>Molecular Sequence Data</term><term>Oligonucleotides, Antisense (pharmacology)</term><term>Protein Biosynthesis (drug effects)</term><term>RNA, Messenger (genetics)</term><term>RNA, Viral (genetics)</term><term>Rabbits</term><term>Viral Matrix Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN viral (génétique)</term><term>Animaux</term><term>Autoradiographie</term><term>Biosynthèse des protéines ()</term><term>Données de séquences moléculaires</term><term>Lapins</term><term>Oligonucléotides antisens (pharmacologie)</term><term>Protéines de la matrice virale (génétique)</term><term>Séquence nucléotidique</term><term>Virus de la grippe A (métabolisme)</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term><term>RNA, Viral</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oligonucleotides, Antisense</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Protein Biosynthesis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>ARN viral</term><term>Protéines de la matrice virale</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oligonucléotides antisens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Autoradiography</term><term>Base Sequence</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Molecular Sequence Data</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autoradiographie</term><term>Biosynthèse des protéines</term><term>Données de séquences moléculaires</term><term>Lapins</term><term>Séquence nucléotidique</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1753959</PMID><DateCompleted><Year>1992</Year><Month>01</Month><Day>28</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0026-8984</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>5</Issue><PubDate><MedlineDate>1991 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Molekuliarnaia biologiia</Title><ISOAbbreviation>Mol. Biol. (Mosk.)</ISOAbbreviation></Journal><ArticleTitle>[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].</ArticleTitle><Pagination><MedlinePgn>1332-7</MedlinePgn></Pagination><Abstract><AbstractText>Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vlasov</LastName><ForeName>V V</ForeName><Initials>VV</Initials></Author><Author ValidYN="Y"><LastName>Gorn</LastName><ForeName>V V</ForeName><Initials>VV</Initials></Author><Author ValidYN="Y"><LastName>Nomokonova</LastName><ForeName>N Iu</ForeName><Initials>NIu</Initials></Author><Author ValidYN="Y"><LastName>Fokina</LastName><ForeName>T N</ForeName><Initials>TN</Initials></Author><Author ValidYN="Y"><LastName>Iurchenko</LastName><ForeName>L V</ForeName><Initials>LV</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Podavlenie transliatsii in vitro mRNK belka M1 virusa grippa s pomoshch'iu antismyslovykh oligonukleotidov.</VernacularTitle></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Mol Biol (Mosk)</MedlineTA><NlmUniqueID>0105454</NlmUniqueID><ISSNLinking>0026-8984</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C031540">M-protein, influenza virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C488936">M1 protein, Influenza A virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016376">Oligonucleotides, Antisense</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014763">Viral Matrix Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001345" MajorTopicYN="N">Autoradiography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004591" MajorTopicYN="N">Electrophoresis, Polyacrylamide Gel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016376" MajorTopicYN="N">Oligonucleotides, Antisense</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014176" MajorTopicYN="N">Protein Biosynthesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014763" MajorTopicYN="N">Viral Matrix Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1753959</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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