[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].
Identifieur interne : 002987 ( PubMed/Curation ); précédent : 002986; suivant : 002988[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].
Auteurs : V V Vlasov ; V V Gorn ; N Iu Nomokonova ; T N Fokina ; L V IurchenkoSource :
- Molekuliarnaia biologiia [ 0026-8984 ]
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN viral (génétique), Animaux, Autoradiographie, Biosynthèse des protéines (), Données de séquences moléculaires, Lapins, Oligonucléotides antisens (pharmacologie), Protéines de la matrice virale (génétique), Séquence nucléotidique, Virus de la grippe A (métabolisme), Électrophorèse sur gel de polyacrylamide.
- MESH :
- génétique : ARN messager, ARN viral, Protéines de la matrice virale.
- métabolisme : Virus de la grippe A.
- pharmacologie : Oligonucléotides antisens.
- Animaux, Autoradiographie, Biosynthèse des protéines, Données de séquences moléculaires, Lapins, Séquence nucléotidique, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Autoradiography, Base Sequence, Electrophoresis, Polyacrylamide Gel, Influenza A virus (metabolism), Molecular Sequence Data, Oligonucleotides, Antisense (pharmacology), Protein Biosynthesis (drug effects), RNA, Messenger (genetics), RNA, Viral (genetics), Rabbits, Viral Matrix Proteins (genetics).
- MESH :
- chemical , genetics : RNA, Messenger, RNA, Viral, Viral Matrix Proteins.
- chemical , pharmacology : Oligonucleotides, Antisense.
- drug effects : Protein Biosynthesis.
- metabolism : Influenza A virus.
- Animals, Autoradiography, Base Sequence, Electrophoresis, Polyacrylamide Gel, Molecular Sequence Data, Rabbits.
Abstract
Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.
PubMed: 1753959
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pubmed:1753959Le document en format XML
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<author><name sortKey="Gorn, V V" sort="Gorn, V V" uniqKey="Gorn V" first="V V" last="Gorn">V V Gorn</name>
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<author><name sortKey="Nomokonova, N Iu" sort="Nomokonova, N Iu" uniqKey="Nomokonova N" first="N Iu" last="Nomokonova">N Iu Nomokonova</name>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autoradiography</term>
<term>Base Sequence</term>
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<term>Biosynthèse des protéines</term>
<term>Données de séquences moléculaires</term>
<term>Lapins</term>
<term>Séquence nucléotidique</term>
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<front><div type="abstract" xml:lang="en">Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.</div>
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<ArticleTitle>[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].</ArticleTitle>
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<Abstract><AbstractText>Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.</AbstractText>
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<VernacularTitle>Podavlenie transliatsii in vitro mRNK belka M1 virusa grippa s pomoshch'iu antismyslovykh oligonukleotidov.</VernacularTitle>
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