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Expression of c-myc is not critical for cell proliferation in established human leukemia lines.

Identifieur interne : 002528 ( PubMed/Curation ); précédent : 002527; suivant : 002529

Expression of c-myc is not critical for cell proliferation in established human leukemia lines.

Auteurs : D M Tidd [Royaume-Uni] ; R V Giles ; C M Broughton ; R E Clark

Source :

BMC molecular biology [ 1471-2199 ] ; 2001.

RBID : pubmed:11734062

Abstract

A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides.

DOI: 10.1186/1471-2199-2-13
PubMed: 11734062

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<author><name sortKey="Tidd, D M" sort="Tidd, D M" uniqKey="Tidd D" first="D M" last="Tidd">D M Tidd</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, The University of Liverpool, Liverpool, UK. dmtidd@liv.ac.uk</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biological Sciences, The University of Liverpool, Liverpool</wicri:regionArea>
</affiliation>
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<author><name sortKey="Giles, R V" sort="Giles, R V" uniqKey="Giles R" first="R V" last="Giles">R V Giles</name>
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<author><name sortKey="Broughton, C M" sort="Broughton, C M" uniqKey="Broughton C" first="C M" last="Broughton">C M Broughton</name>
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<author><name sortKey="Clark, R E" sort="Clark, R E" uniqKey="Clark R" first="R E" last="Clark">R E Clark</name>
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<author><name sortKey="Tidd, D M" sort="Tidd, D M" uniqKey="Tidd D" first="D M" last="Tidd">D M Tidd</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, The University of Liverpool, Liverpool, UK. dmtidd@liv.ac.uk</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Biological Sciences, The University of Liverpool, Liverpool</wicri:regionArea>
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<author><name sortKey="Giles, R V" sort="Giles, R V" uniqKey="Giles R" first="R V" last="Giles">R V Giles</name>
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<author><name sortKey="Broughton, C M" sort="Broughton, C M" uniqKey="Broughton C" first="C M" last="Broughton">C M Broughton</name>
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<author><name sortKey="Clark, R E" sort="Clark, R E" uniqKey="Clark R" first="R E" last="Clark">R E Clark</name>
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<series><title level="j">BMC molecular biology</title>
<idno type="ISSN">1471-2199</idno>
<imprint><date when="2001" type="published">2001</date>
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<front><div type="abstract" xml:lang="en">A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">11734062</PMID>
<DateCompleted><Year>2003</Year>
<Month>10</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>11</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1471-2199</ISSN>
<JournalIssue CitedMedium="Print"><Volume>2</Volume>
<PubDate><Year>2001</Year>
<Month>Nov</Month>
<Day>16</Day>
</PubDate>
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<Title>BMC molecular biology</Title>
<ISOAbbreviation>BMC Mol. Biol.</ISOAbbreviation>
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<ArticleTitle>Expression of c-myc is not critical for cell proliferation in established human leukemia lines.</ArticleTitle>
<Pagination><MedlinePgn>13</MedlinePgn>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">RNase H-active, chimeric methylphosphonodiester / phosphodiester antisense oligodeoxynucleotides targeting bases 1147-1166 of c-myc mRNA downregulated c-Myc protein and induced apoptosis and cell cycle arrest respectively in cultures of MOLT-4 and KYO1 human leukemia cells. In contrast, an RNase H-inactive, morpholino antisense oligonucleotide analogue 28-mer, simultaneously targeting the exon 2 splice acceptor site and initiation codon, reduced c-Myc protein to barely detectable levels but did not affect cell proliferation in these or other leukemia lines. The RNase H-active oligodeoxynucleotide 20-mers contained the phosphodiester linked motif CGTTG, which as an apoptosis inducing CpG oligodeoxynucleotide 5-mer of sequence type CGNNN (N = A, G, C, or T) had potent activity against MOLT-4 cells. The 5-mer mimicked the antiproliferative effects of the 20-mer in the absence of any antisense activity against c-myc mRNA, while the latter still reduced expression of c-myc in a subline of MOLT-4 cells that had been selected for resistance to CGTTA, but in this case the oligodeoxynucleotide failed to induce apoptosis or cell cycle arrest.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We conclude that the biological activity of the chimeric c-myc antisense 20-mers resulted from a non-antisense mechanism related to the CGTTG motif contained within the sequence, and not through downregulation of c-myc. Although the oncogene may have been implicated in the etiology of the original leukemias, expression of c-myc is apparently no longer required to sustain continuous cell proliferation in these culture lines.</AbstractText>
</Abstract>
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<ForeName>R V</ForeName>
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<Author ValidYN="Y"><LastName>Broughton</LastName>
<ForeName>C M</ForeName>
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<Author ValidYN="Y"><LastName>Clark</LastName>
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<ArticleDate DateType="Electronic"><Year>2001</Year>
<Month>11</Month>
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Expression of c-myc is not critical for cell proliferation in established human leukemia lines.

Expression of c-myc is not critical for cell proliferation in established human leukemia lines.

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