Enrichment of transcriptional regulatory sites in non-coding genomic region.
Identifieur interne : 002404 ( PubMed/Curation ); précédent : 002403; suivant : 002405Enrichment of transcriptional regulatory sites in non-coding genomic region.
Auteurs : Wen Xue [République populaire de Chine] ; Jin Wang ; Zhirong Shen ; Huaiqiu ZhuSource :
- Bioinformatics (Oxford, England) [ 1367-4803 ] ; 2004.
Descripteurs français
- KwdFr :
- Algorithmes, Alignement de séquences (), Analyse de profil d'expression de gènes (), Analyse de séquence d'ADN (), Animaux, Cadres ouverts de lecture (génétique), Drosophila melanogaster (génétique), Gènes régulateurs (génétique), Génome, Génome fongique, Génome viral, Herpèsvirus humain de type 4 (génétique), Régulation de l'expression des gènes (génétique), Saccharomyces cerevisiae (génétique), Séquence conservée, Transcription génétique (génétique).
- MESH :
- génétique : Cadres ouverts de lecture, Drosophila melanogaster, Gènes régulateurs, Herpèsvirus humain de type 4, Régulation de l'expression des gènes, Saccharomyces cerevisiae, Transcription génétique.
- Algorithmes, Alignement de séquences, Analyse de profil d'expression de gènes, Analyse de séquence d'ADN, Animaux, Génome, Génome fongique, Génome viral, Séquence conservée.
English descriptors
- KwdEn :
- Algorithms, Animals, Conserved Sequence, Drosophila melanogaster (genetics), Gene Expression Profiling (methods), Gene Expression Regulation (genetics), Genes, Regulator (genetics), Genome, Genome, Fungal, Genome, Viral, Herpesvirus 4, Human (genetics), Open Reading Frames (genetics), Saccharomyces cerevisiae (genetics), Sequence Alignment (methods), Sequence Analysis, DNA (methods), Transcription, Genetic (genetics).
- MESH :
- genetics : Drosophila melanogaster, Gene Expression Regulation, Genes, Regulator, Herpesvirus 4, Human, Open Reading Frames, Saccharomyces cerevisiae, Transcription, Genetic.
- methods : Gene Expression Profiling, Sequence Alignment, Sequence Analysis, DNA.
- Algorithms, Animals, Conserved Sequence, Genome, Genome, Fungal, Genome, Viral.
Abstract
Over-represented k-mers in non-coding genomic regions often lead to identification of potential transcriptional regulatory sites (TRS). This phenomenon has been employed by many algorithms to predict TRS in silico. Yet, the improvement of these algorithms should be based on deeper understanding of the enrichment feature. To obtain a general distributional profile of TRS in different regions of genomes as well as in different genomes, we here performed a systematic analysis on the over-representation of TRS in intergenic regions and gene upstream regions of yeasts and viral genomes, and the distributional pattern of TRS in intergenic and intron regions of the Drosophila genome. We also explored the way to evaluate the accuracy of TRS consensus sequences by measuring their enrichment.
DOI: 10.1093/bioinformatics/btg450
PubMed: 14990453
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pubmed:14990453Le document en format XML
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<term>Gene Expression Regulation (genetics)</term>
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<term>Gènes régulateurs</term>
<term>Herpèsvirus humain de type 4</term>
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<term>Alignement de séquences</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de séquence d'ADN</term>
<term>Animaux</term>
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<front><div type="abstract" xml:lang="en">Over-represented k-mers in non-coding genomic regions often lead to identification of potential transcriptional regulatory sites (TRS). This phenomenon has been employed by many algorithms to predict TRS in silico. Yet, the improvement of these algorithms should be based on deeper understanding of the enrichment feature. To obtain a general distributional profile of TRS in different regions of genomes as well as in different genomes, we here performed a systematic analysis on the over-representation of TRS in intergenic regions and gene upstream regions of yeasts and viral genomes, and the distributional pattern of TRS in intergenic and intron regions of the Drosophila genome. We also explored the way to evaluate the accuracy of TRS consensus sequences by measuring their enrichment.</div>
</front>
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<Month>06</Month>
<Day>24</Day>
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<DateRevised><Year>2019</Year>
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<ArticleTitle>Enrichment of transcriptional regulatory sites in non-coding genomic region.</ArticleTitle>
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<Abstract><AbstractText Label="MOTIVATION" NlmCategory="BACKGROUND">Over-represented k-mers in non-coding genomic regions often lead to identification of potential transcriptional regulatory sites (TRS). This phenomenon has been employed by many algorithms to predict TRS in silico. Yet, the improvement of these algorithms should be based on deeper understanding of the enrichment feature. To obtain a general distributional profile of TRS in different regions of genomes as well as in different genomes, we here performed a systematic analysis on the over-representation of TRS in intergenic regions and gene upstream regions of yeasts and viral genomes, and the distributional pattern of TRS in intergenic and intron regions of the Drosophila genome. We also explored the way to evaluate the accuracy of TRS consensus sequences by measuring their enrichment.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">To measure enrichment, a statistical background model was introduced by comparing TRS frequency in certain regions of genome to either the frequency in the whole genome or the frequency in exon region. This model was applied to different classes of non-coding genomic regions in four genomes. Most of the TRS were observed to be over-represented in the intergenic regions of the Saccharomyces cerevisiae, Schizosaccharomyces pombe and Epstein-Barr virus (EBV) genomes. The enrichment of S.cerevisiae TRS in the 600 bp upstream region of genes was also significant. In Drosophila genome, TRS did not show enrichment in intergenic and intron regions when TRS frequency in the whole genome was taken as background, as we did in other genomes. However, when we took TRS frequency in exon region as background, over 70% TRS are over-represented in those two classes of non-coding regions. This fact indicates the existence of transcriptional regulatory signals in introns. The analysis of some S.cerevisiae TRS, which have inconsistent consensus sequences with different levels of enrichment in intergenic region, suggests the possibility of evaluating the accuracy of experimentally determined TRS by measuring their enrichment in non-coding genomic regions.</AbstractText>
</Abstract>
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