Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.
Identifieur interne : 002166 ( PubMed/Curation ); précédent : 002165; suivant : 002167Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.
Auteurs : Mark Js Miller [États-Unis] ; Paul Bobrowski ; Meenakshi Shukla ; Kalpana Gupta ; Tariq M. HaqqiSource :
- Journal of inflammation (London, England) [ 1476-9255 ] ; 2007.
Abstract
The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evaluated for antioxidant activity and possible chondroprotective actions.
DOI: 10.1186/1476-9255-4-16
PubMed: 17697350
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002166
Links to Exploration step
pubmed:17697350Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.</title><author><name sortKey="Miller, Mark Js" sort="Miller, Mark Js" uniqKey="Miller M" first="Mark Js" last="Miller">Mark Js Miller</name><affiliation wicri:level="1"><nlm:affiliation>Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. markjsm03@yahoo.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cardiovascular Sciences, Albany Medical College, Albany, New York</wicri:regionArea></affiliation></author><author><name sortKey="Bobrowski, Paul" sort="Bobrowski, Paul" uniqKey="Bobrowski P" first="Paul" last="Bobrowski">Paul Bobrowski</name></author><author><name sortKey="Shukla, Meenakshi" sort="Shukla, Meenakshi" uniqKey="Shukla M" first="Meenakshi" last="Shukla">Meenakshi Shukla</name></author><author><name sortKey="Gupta, Kalpana" sort="Gupta, Kalpana" uniqKey="Gupta K" first="Kalpana" last="Gupta">Kalpana Gupta</name></author><author><name sortKey="Haqqi, Tariq M" sort="Haqqi, Tariq M" uniqKey="Haqqi T" first="Tariq M" last="Haqqi">Tariq M. Haqqi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17697350</idno><idno type="pmid">17697350</idno><idno type="doi">10.1186/1476-9255-4-16</idno><idno type="wicri:Area/PubMed/Corpus">002166</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002166</idno><idno type="wicri:Area/PubMed/Curation">002166</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.</title><author><name sortKey="Miller, Mark Js" sort="Miller, Mark Js" uniqKey="Miller M" first="Mark Js" last="Miller">Mark Js Miller</name><affiliation wicri:level="1"><nlm:affiliation>Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. markjsm03@yahoo.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cardiovascular Sciences, Albany Medical College, Albany, New York</wicri:regionArea></affiliation></author><author><name sortKey="Bobrowski, Paul" sort="Bobrowski, Paul" uniqKey="Bobrowski P" first="Paul" last="Bobrowski">Paul Bobrowski</name></author><author><name sortKey="Shukla, Meenakshi" sort="Shukla, Meenakshi" uniqKey="Shukla M" first="Meenakshi" last="Shukla">Meenakshi Shukla</name></author><author><name sortKey="Gupta, Kalpana" sort="Gupta, Kalpana" uniqKey="Gupta K" first="Kalpana" last="Gupta">Kalpana Gupta</name></author><author><name sortKey="Haqqi, Tariq M" sort="Haqqi, Tariq M" uniqKey="Haqqi T" first="Tariq M" last="Haqqi">Tariq M. Haqqi</name></author></analytic><series><title level="j">Journal of inflammation (London, England)</title><idno type="eISSN">1476-9255</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evaluated for antioxidant activity and possible chondroprotective actions.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">17697350</PMID><DateCompleted><Year>2011</Year><Month>07</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1476-9255</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><PubDate><Year>2007</Year><Month>Aug</Month><Day>14</Day></PubDate></JournalIssue><Title>Journal of inflammation (London, England)</Title><ISOAbbreviation>J Inflamm (Lond)</ISOAbbreviation></Journal><ArticleTitle>Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.</ArticleTitle><Pagination><MedlinePgn>16</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evaluated for antioxidant activity and possible chondroprotective actions.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Acute oral safety and toxicity was tested in rats according under OECD protocol number 420. The profile of proanthocyanidin oligomers was determined by HPLC and progrado's antioxidant activity quantified by the ORAC, NORAC and HORAC assays. Human cartilage explants, obtained from surgical specimens, were used to assess chondroproteciton with activity related to direct inhibitory effects on human matrix metalloproteinase (MMP, gelatinolytic) activity using synovial fluid and chondrocytes activated with IL-1beta (10 ng/ml). Additionally, progrado (2-10 mug/ml) was tested for its ability to maintain optimal IGF-1 transcription and translation in cartilage explants and cultured chondrocytes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Both progrado and zangrado at doses up to 2000 mg/kg (po) displayed no evidence of toxicity. Oligomeric proanthocyanidin content was high for both progrado (158 mg/kg) and zangrado (124 mg/kg), with zangrado almost entirely composed of short oligomers (<6 mer), whereas the majority of oligomers in progrado exceeded 10 mers. Progrado was a remarkably potent antioxidant in the standardized tests ORAC, NORAC and HORAC. Progrado was exceptionally effective in reducing both basal and IL-1beta induced glycosaminoglycan release from human cartilage explants at concentrations that also directly blocked the gelatinolytic activity of MMP-2 and MMP-9. Progrado prevented IL-1beta induced suppression of IGF-1 production from human cartilage explants as well as stimulating basal IGF-1 production (P < 0.05). Comparable changes in IGF-1 gene expression were noted in cultured human chondrocytes.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Progrado has a promising safety profile, significant chondroprotective and antioxidant actions, directly inhibits MMP activity and promotes the production of the cartilage repair factor, IGF-1. This suggests that progrado may offer therapeutic benefits in joint health, wound healing and inflammation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Mark Js</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. markjsm03@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bobrowski</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Shukla</LastName><ForeName>Meenakshi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Kalpana</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Haqqi</LastName><ForeName>Tariq M</ForeName><Initials>TM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>08</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Inflamm (Lond)</MedlineTA><NlmUniqueID>101232234</NlmUniqueID><ISSNLinking>1476-9255</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>08</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17697350</ArticleId><ArticleId IdType="pii">1476-9255-4-16</ArticleId><ArticleId IdType="doi">10.1186/1476-9255-4-16</ArticleId><ArticleId IdType="pmc">PMC1971260</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Ethnopharmacol. 2002 May;80(2-3):121-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12007701</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Complement Altern Med. 2006;6:13</Citation><ArticleIdList><ArticleId IdType="pubmed">16603065</ArticleId></ArticleIdList></Reference><Reference><Citation>J Invest Dermatol. 2001 Sep;117(3):725-30</Citation><ArticleIdList><ArticleId IdType="pubmed">11564183</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol. 1999 Jan;276(1 Pt 1):G58-63</Citation><ArticleIdList><ArticleId IdType="pubmed">9886979</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2006 Feb 23;354(8):795-808</Citation><ArticleIdList><ArticleId IdType="pubmed">16495392</ArticleId></ArticleIdList></Reference><Reference><Citation>Free Radic Biol Med. 2002 Oct 15;33(8):1097-105</Citation><ArticleIdList><ArticleId IdType="pubmed">12374621</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4524-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10200295</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Rheum Dis. 2001 Mar;60(3):254-61</Citation><ArticleIdList><ArticleId IdType="pubmed">11171688</ArticleId></ArticleIdList></Reference><Reference><Citation>J Orthop Res. 2005 Jan;23(1):118-26</Citation><ArticleIdList><ArticleId IdType="pubmed">15607883</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr. 2005 Sep;135(9):2096-102</Citation><ArticleIdList><ArticleId IdType="pubmed">16140882</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol. 1999 Apr;276(4 Pt 1):G795-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10198320</ArticleId></ArticleIdList></Reference><Reference><Citation>Evid Based Complement Alternat Med. 2005 Sep;2(3):301-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16136208</ArticleId></ArticleIdList></Reference><Reference><Citation>Gene Ther. 2005 Aug;12(15):1171-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15815701</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytochemistry. 1995 Apr;38(6):1319-43</Citation><ArticleIdList><ArticleId IdType="pubmed">7786474</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Gastrointest Liver Physiol. 2000 Jul;279(1):G192-200</Citation><ArticleIdList><ArticleId IdType="pubmed">10898763</ArticleId></ArticleIdList></Reference><Reference><Citation>Handb Exp Pharmacol. 2007;(179):155-71</Citation><ArticleIdList><ArticleId IdType="pubmed">17217056</ArticleId></ArticleIdList></Reference><Reference><Citation>J Orthop Res. 2003 Jan;21(1):102-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12507586</ArticleId></ArticleIdList></Reference><Reference><Citation>Histochem J. 1996 Dec;28(12):835-57</Citation><ArticleIdList><ArticleId IdType="pubmed">9015706</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Nutr. 2006 Dec;45(8):428-38</Citation><ArticleIdList><ArticleId IdType="pubmed">17036262</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Res Ther. 2004;6(5):R393-403</Citation><ArticleIdList><ArticleId IdType="pubmed">15380039</ArticleId></ArticleIdList></Reference><Reference><Citation>Planta Med. 1989 Apr;55(2):140-3</Citation><ArticleIdList><ArticleId IdType="pubmed">2748730</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Rep. 2005;57 Suppl:97-107</Citation><ArticleIdList><ArticleId IdType="pubmed">16415490</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytomedicine. 1994 Sep;1(2):77-106</Citation><ArticleIdList><ArticleId IdType="pubmed">23195881</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2006 Nov 16;444(7117):337-42</Citation><ArticleIdList><ArticleId IdType="pubmed">17086191</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Gastroenterol. 1999 Nov;94(11):3267-73</Citation><ArticleIdList><ArticleId IdType="pubmed">10566728</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Oct 5;276(40):37258-65</Citation><ArticleIdList><ArticleId IdType="pubmed">11486009</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 1986 Sep 4;883(2):173-7</Citation><ArticleIdList><ArticleId IdType="pubmed">3091074</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002166 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002166 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:17697350
|texte= Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:17697350" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |