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SPRi-based strategy to identify specific biomarkers in systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis.

Identifieur interne : 001A99 ( PubMed/Curation ); précédent : 001A98; suivant : 001B00

SPRi-based strategy to identify specific biomarkers in systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis.

Auteurs : Elvire Beleoken [France] ; Hervé Leh [France] ; Armelle Arnoux [France] ; Béatrice Ducot [France] ; Claude Nogues [France] ; Eleonora De Martin [France] ; Catherine Johanet [France] ; Didier Samuel [France] ; Mohammad Zahid Mustafa [France] ; Jean-Charles Duclos-Vallée [France] ; Malcolm Buckle [France] ; Eric Ballot [France]

Source :

PloS one [ 1932-6203 ] ; 2013.

RBID : pubmed:24376828

Descripteurs français

English descriptors

KwdEn :
- Antibodies, Antinuclear (metabolism), Arthritis, Rheumatoid (metabolism), Biomarkers (metabolism), Electrophoresis, Polyacrylamide Gel, Fluorescent Antibody Technique, Indirect, Hepatitis, Autoimmune (metabolism), Heterogeneous-Nuclear Ribonucleoprotein Group A-B (metabolism), Humans, Immunoblotting, Lupus Erythematosus, Systemic (metabolism), Peptides (metabolism), Statistics, Nonparametric, Surface Plasmon Resonance (methods).
MESH :
- chemical , metabolism : Antibodies, Antinuclear, Biomarkers, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, Peptides.
- metabolism : Arthritis, Rheumatoid, Hepatitis, Autoimmune, Lupus Erythematosus, Systemic.
- methods : Surface Plasmon Resonance.
- Electrophoresis, Polyacrylamide Gel, Fluorescent Antibody Technique, Indirect, Humans, Immunoblotting, Statistics, Nonparametric.

Abstract

Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is a target for antinuclear autoantibodies in systemic Lupus erythematosus (SLE), rheumatoid arthritis (RA), and autoimmune hepatitis (AIH).

DOI: 10.1371/journal.pone.0084600
PubMed: 24376828

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<author><name sortKey="Samuel, Didier" sort="Samuel, Didier" uniqKey="Samuel D" first="Didier" last="Samuel">Didier Samuel</name>
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<author><name sortKey="Mustafa, Mohammad Zahid" sort="Mustafa, Mohammad Zahid" uniqKey="Mustafa M" first="Mohammad Zahid" last="Mustafa">Mohammad Zahid Mustafa</name>
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<author><name sortKey="Duclos Vallee, Jean Charles" sort="Duclos Vallee, Jean Charles" uniqKey="Duclos Vallee J" first="Jean-Charles" last="Duclos-Vallée">Jean-Charles Duclos-Vallée</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="De Martin, Eleonora" sort="De Martin, Eleonora" uniqKey="De Martin E" first="Eleonora" last="De Martin">Eleonora De Martin</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Research Unit 785, Inserm, Villejuif, France ; Faculte de Medecine, University Paris-Sud, Villejuif, France ; Laboratoire Immunologie, AP-HP Hopital Saint-Antoine, Paris</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Samuel, Didier" sort="Samuel, Didier" uniqKey="Samuel D" first="Didier" last="Samuel">Didier Samuel</name>
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<author><name sortKey="Mustafa, Mohammad Zahid" sort="Mustafa, Mohammad Zahid" uniqKey="Mustafa M" first="Mohammad Zahid" last="Mustafa">Mohammad Zahid Mustafa</name>
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<author><name sortKey="Duclos Vallee, Jean Charles" sort="Duclos Vallee, Jean Charles" uniqKey="Duclos Vallee J" first="Jean-Charles" last="Duclos-Vallée">Jean-Charles Duclos-Vallée</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Unit 785, Inserm, Villejuif, France ; Faculte de Medecine, University Paris-Sud, Villejuif, France ; Centre Hépato-Biliaire, AP-HP Hôpital Paul Brousse, Villejuif, France.</nlm:affiliation>
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<author><name sortKey="Buckle, Malcolm" sort="Buckle, Malcolm" uniqKey="Buckle M" first="Malcolm" last="Buckle">Malcolm Buckle</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Ballot, Eric" sort="Ballot, Eric" uniqKey="Ballot E" first="Eric" last="Ballot">Eric Ballot</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Antinuclear (metabolism)</term>
<term>Arthritis, Rheumatoid (metabolism)</term>
<term>Biomarkers (metabolism)</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Fluorescent Antibody Technique, Indirect</term>
<term>Hepatitis, Autoimmune (metabolism)</term>
<term>Heterogeneous-Nuclear Ribonucleoprotein Group A-B (metabolism)</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Lupus Erythematosus, Systemic (metabolism)</term>
<term>Peptides (metabolism)</term>
<term>Statistics, Nonparametric</term>
<term>Surface Plasmon Resonance (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antinucléaires (métabolisme)</term>
<term>Humains</term>
<term>Hépatite auto-immune (métabolisme)</term>
<term>Immunotransfert</term>
<term>Lupus érythémateux disséminé (métabolisme)</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Peptides (métabolisme)</term>
<term>Polyarthrite rhumatoïde (métabolisme)</term>
<term>Ribonucléoprotéine nucléaire hétérogène du groupe A-B (métabolisme)</term>
<term>Résonance plasmonique de surface ()</term>
<term>Statistique non paramétrique</term>
<term>Technique d'immunofluorescence indirecte</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antibodies, Antinuclear</term>
<term>Biomarkers</term>
<term>Heterogeneous-Nuclear Ribonucleoprotein Group A-B</term>
<term>Peptides</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Hepatitis, Autoimmune</term>
<term>Lupus Erythematosus, Systemic</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Surface Plasmon Resonance</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anticorps antinucléaires</term>
<term>Hépatite auto-immune</term>
<term>Lupus érythémateux disséminé</term>
<term>Marqueurs biologiques</term>
<term>Peptides</term>
<term>Polyarthrite rhumatoïde</term>
<term>Ribonucléoprotéine nucléaire hétérogène du groupe A-B</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Electrophoresis, Polyacrylamide Gel</term>
<term>Fluorescent Antibody Technique, Indirect</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Immunotransfert</term>
<term>Résonance plasmonique de surface</term>
<term>Statistique non paramétrique</term>
<term>Technique d'immunofluorescence indirecte</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
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<front><div type="abstract" xml:lang="en">Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is a target for antinuclear autoantibodies in systemic Lupus erythematosus (SLE), rheumatoid arthritis (RA), and autoimmune hepatitis (AIH).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24376828</PMID>
<DateCompleted><Year>2014</Year>
<Month>10</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>12</Issue>
<PubDate><Year>2013</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>SPRi-based strategy to identify specific biomarkers in systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis.</ArticleTitle>
<Pagination><MedlinePgn>e84600</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0084600</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is a target for antinuclear autoantibodies in systemic Lupus erythematosus (SLE), rheumatoid arthritis (RA), and autoimmune hepatitis (AIH).</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">To monitor molecular interactions between peptides spanning the entire sequence of hnRNP A2/B1 and sera from patients and healthy controls.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Sera from 8 patients from each pathology and controls were passed across a surface plasmon resonance Imagery (SPRi) surface containing 39 overlapping peptides of 17 mers covering the human hnRNP B1. Interactions involving the immobilised peptides were followed in real time and dissociation rate constants k(off) for each interaction were calculated.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Several significant interactions were observed: i) high stability (lower k(off) values) between P₅₅₋₇₀ and the AIH sera compared to controls (p= 0.003); ii) lower stability (higher k(off) values) between P₁₁₈₋₁₃₃ and P₂₆₂₋₂₇₇ and SLE sera, P₁₄₅₋₁₆₀ and RA sera compared to controls (p=0.006, p=0.002, p=0.007). The binding curves and k(off) values observed after the formation of complexes with anti-IgM and anti-IgG antibodies and after nuclease treatment of the serum indicate that i) IgM isotypes are prevalent and ii) nucleic acids participate in the interaction between anti-hnRNAP B1 and P₅₅₋₇₀ and also between controls and the peptides studied.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results indicate that P₅₅₋₇₀ of hnRNP B1 is a potential biomarker for AIH in immunological tests and suggest the role of circulating nucleic acids, (eg miRNA), present or absent according to the autoimmune disorders and involved in antigen-antibody stability.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Beleoken</LastName>
<ForeName>Elvire</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Research Unit 785, Inserm, Villejuif, France ; Faculte de Medecine, University Paris-Sud, Villejuif, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leh</LastName>
<ForeName>Hervé</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Biologie et de Pharmacologie Appliquée, ENS Cachan - CNRS, Cachan, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arnoux</LastName>
<ForeName>Armelle</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Unité de Recherche Clinique, AP-HP Hopital Bicetre, Le Kremlin-Bicetre, France.</Affiliation>
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SPRi-based strategy to identify specific biomarkers in systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis.

SPRi-based strategy to identify specific biomarkers in systemic lupus erythematosus, rheumatoid arthritis and autoimmune hepatitis.

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