Transmission of MERS-coronavirus in household contacts.
Identifieur interne : 001866 ( PubMed/Curation ); précédent : 001865; suivant : 001867Transmission of MERS-coronavirus in household contacts.
Auteurs : Christian Drosten ; Benjamin Meyer ; Marcel A. Müller ; Victor M. Corman ; Malak Al-Masri ; Raheela Hossain ; Hosam Madani ; Andrea Sieberg ; Berend Jan Bosch ; Erik Lattwein ; Raafat F. Alhakeem ; Abdullah M. Assiri ; Waleed Hajomar ; Ali M. Albarrak ; Jaffar A. Al-Tawfiq ; Alimuddin I. Zumla ; Ziad A. MemishSource :
- The New England journal of medicine [ 1533-4406 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Adolescent, Adulte, Caractéristiques familiales, Coronavirus (génétique), Coronavirus (isolement et purification), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections de l'appareil respiratoire (transmission), Infections à coronavirus (transmission), Moyen Orient, Mâle, Pharynx (virologie), RT-PCR, Sujet âgé, Technique d'immunofluorescence.
- MESH :
- analyse : ARN viral.
- génétique : Coronavirus.
- isolement et purification : Coronavirus.
- virologie : Pharynx.
- Adolescent, Adulte, Caractéristiques familiales, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections de l'appareil respiratoire, Infections à coronavirus, Moyen Orient, Mâle, RT-PCR, Sujet âgé, Technique d'immunofluorescence.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Child, Child, Preschool, Coronavirus (genetics), Coronavirus (isolation & purification), Coronavirus Infections (transmission), Family Characteristics, Female, Fluorescent Antibody Technique, Humans, Male, Middle East, Pharynx (virology), RNA, Viral (analysis), Respiratory Tract Infections (transmission), Reverse Transcriptase Polymerase Chain Reaction.
- MESH :
- chemical , analysis : RNA, Viral.
- geographic : Middle East.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- transmission : Coronavirus Infections, Respiratory Tract Infections.
- virology : Pharynx.
- Adolescent, Adult, Aged, Child, Child, Preschool, Family Characteristics, Female, Fluorescent Antibody Technique, Humans, Male, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-CoV) depend on knowledge of the rate of human-to-human transmission, including subclinical infections. A lack of serologic tools has hindered targeted studies of transmission.
DOI: 10.1056/NEJMoa1405858
PubMed: 25162889
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Christian Drosten<affiliation><nlm:affiliation>From the Institute of Virology, University of Bonn Medical Center, Bonn (C.D., B.M., M.A.M., V.M.C., A.S.), and Euroimmun, Lübeck (E.L.) - both in Germany; Global Center for Mass Gatherings Medicine, Ministry of Health (M.A.-M., R.F.A., A.M. Assiri, A.I.Z., Z.A.M.), Prince Sultan Military Medical City (A.M. Albarrak), and Alfaisal University (Z.A.M.), Riyadh, Johns Hopkins Aramco Healthcare, Dhahran (J.A.A.-T.), and Regional Laboratory, Ministry of Health, Jeddah (R.H., H.M.) and Riyadh (W.H.) - all in Saudi Arabia; Indiana University School of Medicine, Indianapolis (J.A.A.-T.); the Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands (B.J.B.); and the Division of Infection and Immunity, University College London (UCL), and National Institute for Health Research Biomedical Research Centre, UCL Hospitals, London (A.I.Z.).</nlm:affiliation>
<wicri:noCountry code="subField">London (A.I.Z.).</wicri:noCountry>
</affiliation>
Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Transmission of MERS-coronavirus in household contacts.</title>
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<wicri:noCountry code="subField">London (A.I.Z.).</wicri:noCountry>
</affiliation>
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<author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M" last="Corman">Victor M. Corman</name>
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<author><name sortKey="Al Masri, Malak" sort="Al Masri, Malak" uniqKey="Al Masri M" first="Malak" last="Al-Masri">Malak Al-Masri</name>
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<author><name sortKey="Hossain, Raheela" sort="Hossain, Raheela" uniqKey="Hossain R" first="Raheela" last="Hossain">Raheela Hossain</name>
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<author><name sortKey="Madani, Hosam" sort="Madani, Hosam" uniqKey="Madani H" first="Hosam" last="Madani">Hosam Madani</name>
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<author><name sortKey="Alhakeem, Raafat F" sort="Alhakeem, Raafat F" uniqKey="Alhakeem R" first="Raafat F" last="Alhakeem">Raafat F. Alhakeem</name>
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<author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M" last="Assiri">Abdullah M. Assiri</name>
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<author><name sortKey="Hajomar, Waleed" sort="Hajomar, Waleed" uniqKey="Hajomar W" first="Waleed" last="Hajomar">Waleed Hajomar</name>
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<author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M" last="Albarrak">Ali M. Albarrak</name>
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<author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A" last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
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<author><name sortKey="Zumla, Alimuddin I" sort="Zumla, Alimuddin I" uniqKey="Zumla A" first="Alimuddin I" last="Zumla">Alimuddin I. Zumla</name>
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<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A" last="Memish">Ziad A. Memish</name>
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<series><title level="j">The New England journal of medicine</title>
<idno type="eISSN">1533-4406</idno>
<imprint><date when="2014" type="published">2014</date>
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<term>Adult</term>
<term>Aged</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (isolation & purification)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Family Characteristics</term>
<term>Female</term>
<term>Fluorescent Antibody Technique</term>
<term>Humans</term>
<term>Male</term>
<term>Middle East</term>
<term>Pharynx (virology)</term>
<term>RNA, Viral (analysis)</term>
<term>Respiratory Tract Infections (transmission)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Adulte</term>
<term>Caractéristiques familiales</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (isolement et purification)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire (transmission)</term>
<term>Infections à coronavirus (transmission)</term>
<term>Moyen Orient</term>
<term>Mâle</term>
<term>Pharynx (virologie)</term>
<term>RT-PCR</term>
<term>Sujet âgé</term>
<term>Technique d'immunofluorescence</term>
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<term>Respiratory Tract Infections</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pharynx</term>
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<term>Adult</term>
<term>Aged</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Family Characteristics</term>
<term>Female</term>
<term>Fluorescent Antibody Technique</term>
<term>Humans</term>
<term>Male</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Adulte</term>
<term>Caractéristiques familiales</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire</term>
<term>Infections à coronavirus</term>
<term>Moyen Orient</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-CoV) depend on knowledge of the rate of human-to-human transmission, including subclinical infections. A lack of serologic tools has hindered targeted studies of transmission.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25162889</PMID>
<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>08</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>371</Volume>
<Issue>9</Issue>
<PubDate><Year>2014</Year>
<Month>Aug</Month>
<Day>28</Day>
</PubDate>
</JournalIssue>
<Title>The New England journal of medicine</Title>
<ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Transmission of MERS-coronavirus in household contacts.</ArticleTitle>
<Pagination><MedlinePgn>828-35</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1056/NEJMoa1405858</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-CoV) depend on knowledge of the rate of human-to-human transmission, including subclinical infections. A lack of serologic tools has hindered targeted studies of transmission.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We studied 26 index patients with MERS-CoV infection and their 280 household contacts. The median time from the onset of symptoms in index patients to the latest blood sampling in contact patients was 17.5 days (range, 5 to 216; mean, 34.4). Probable cases of secondary transmission were identified on the basis of reactivity in two reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assays with independent RNA extraction from throat swabs or reactivity on enzyme-linked immunosorbent assay against MERS-CoV S1 antigen, supported by reactivity on recombinant S-protein immunofluorescence and demonstration of neutralization of more than 50% of the infectious virus seed dose on plaque-reduction neutralization testing.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Among the 280 household contacts of the 26 index patients, there were 12 probable cases of secondary transmission (4%; 95% confidence interval, 2 to 7). Of these cases, 7 were identified by means of RT-PCR, all in samples obtained within 14 days after the onset of symptoms in index patients, and 5 were identified by means of serologic analysis, all in samples obtained 13 days or more after symptom onset in index patients. Probable cases of secondary transmission occurred in 6 of 26 clusters (23%). Serologic results in contacts who were sampled 13 days or more after exposure were similar to overall study results for combined RT-PCR and serologic testing.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The rate of secondary transmission among household contacts of patients with MERS-CoV infection has been approximately 5%. Our data provide insight into the rate of subclinical transmission of MERS-CoV in the home.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drosten</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>From the Institute of Virology, University of Bonn Medical Center, Bonn (C.D., B.M., M.A.M., V.M.C., A.S.), and Euroimmun, Lübeck (E.L.) - both in Germany; Global Center for Mass Gatherings Medicine, Ministry of Health (M.A.-M., R.F.A., A.M. Assiri, A.I.Z., Z.A.M.), Prince Sultan Military Medical City (A.M. Albarrak), and Alfaisal University (Z.A.M.), Riyadh, Johns Hopkins Aramco Healthcare, Dhahran (J.A.A.-T.), and Regional Laboratory, Ministry of Health, Jeddah (R.H., H.M.) and Riyadh (W.H.) - all in Saudi Arabia; Indiana University School of Medicine, Indianapolis (J.A.A.-T.); the Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands (B.J.B.); and the Division of Infection and Immunity, University College London (UCL), and National Institute for Health Research Biomedical Research Centre, UCL Hospitals, London (A.I.Z.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meyer</LastName>
<ForeName>Benjamin</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Müller</LastName>
<ForeName>Marcel A</ForeName>
<Initials>MA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Corman</LastName>
<ForeName>Victor M</ForeName>
<Initials>VM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Al-Masri</LastName>
<ForeName>Malak</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hossain</LastName>
<ForeName>Raheela</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Madani</LastName>
<ForeName>Hosam</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sieberg</LastName>
<ForeName>Andrea</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bosch</LastName>
<ForeName>Berend Jan</ForeName>
<Initials>BJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lattwein</LastName>
<ForeName>Erik</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alhakeem</LastName>
<ForeName>Raafat F</ForeName>
<Initials>RF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Assiri</LastName>
<ForeName>Abdullah M</ForeName>
<Initials>AM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hajomar</LastName>
<ForeName>Waleed</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Albarrak</LastName>
<ForeName>Ali M</ForeName>
<Initials>AM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Al-Tawfiq</LastName>
<ForeName>Jaffar A</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zumla</LastName>
<ForeName>Alimuddin I</ForeName>
<Initials>AI</Initials>
</Author>
<Author ValidYN="Y"><LastName>Memish</LastName>
<ForeName>Ziad A</ForeName>
<Initials>ZA</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>N Engl J Med</MedlineTA>
<NlmUniqueID>0255562</NlmUniqueID>
<ISSNLinking>0028-4793</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017934" MajorTopicYN="Y">Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005191" MajorTopicYN="N">Family Characteristics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005455" MajorTopicYN="N">Fluorescent Antibody Technique</DescriptorName>
</MeshHeading>
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<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
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<ArticleId IdType="doi">10.1056/NEJMoa1405858</ArticleId>
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