MersV1, PubMed, Curation, bibRecord, 001783

Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.

Identifieur interne : 001783 ( PubMed/Curation ); précédent : 001782; suivant : 001784

Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.

Auteurs : Danielle R. Adney ; Neeltje Van Doremalen ; Vienna R. Brown ; Trenton Bushmaker ; Dana Scott ; Emmie De Wit ; Richard A. Bowen ; Vincent J. Munster

Source :

Emerging infectious diseases [ 1080-6059 ] ; 2014.

RBID : pubmed:25418529

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Anticorps neutralisants (sang), Chameaux (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Excrétion virale, Infections de l'appareil respiratoire (diagnostic), Infections de l'appareil respiratoire (immunologie), Infections de l'appareil respiratoire (médecine vétérinaire), Infections de l'appareil respiratoire (virologie), Infections à coronavirus (diagnostic), Infections à coronavirus (immunologie), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (virologie), Mâle, Réplication virale, Tropisme viral.
MESH :
- diagnostic : Infections de l'appareil respiratoire, Infections à coronavirus.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Infections de l'appareil respiratoire, Infections à coronavirus.
- médecine vétérinaire : Infections de l'appareil respiratoire, Infections à coronavirus.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Chameaux, Infections de l'appareil respiratoire, Infections à coronavirus.
- Animaux, Excrétion virale, Mâle, Réplication virale, Tropisme viral.

English descriptors

KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Camelus (virology), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Male, Middle East Respiratory Syndrome Coronavirus (physiology), Respiratory Tract Infections (diagnosis), Respiratory Tract Infections (immunology), Respiratory Tract Infections (veterinary), Respiratory Tract Infections (virology), Viral Tropism, Virus Replication, Virus Shedding.
MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral.
- diagnosis : Coronavirus Infections, Respiratory Tract Infections.
- immunology : Coronavirus Infections, Respiratory Tract Infections.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections, Respiratory Tract Infections.
- virology : Camelus, Coronavirus Infections, Respiratory Tract Infections.
- Animals, Male, Viral Tropism, Virus Replication, Virus Shedding.

Abstract

In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Here we provide experimental support for camels as a reservoir for MERS-CoV. We inoculated 3 adult camels with a human isolate of MERS-CoV and a transient, primarily upper respiratory tract infection developed in each of the 3 animals. Clinical signs of the MERS-CoV infection were benign, but each of the camels shed large quantities of virus from the upper respiratory tract. We detected infectious virus in nasal secretions through 7 days postinoculation, and viral RNA up to 35 days postinoculation. The pattern of shedding and propensity for the upper respiratory tract infection in dromedary camels may help explain the lack of systemic illness among naturally infected camels and the means of efficient camel-to-camel and camel-to-human transmission.

DOI: 10.3201/eid2012.141280
PubMed: 25418529

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Le document en format XML

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<front><div type="abstract" xml:lang="en">In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Here we provide experimental support for camels as a reservoir for MERS-CoV. We inoculated 3 adult camels with a human isolate of MERS-CoV and a transient, primarily upper respiratory tract infection developed in each of the 3 animals. Clinical signs of the MERS-CoV infection were benign, but each of the camels shed large quantities of virus from the upper respiratory tract. We detected infectious virus in nasal secretions through 7 days postinoculation, and viral RNA up to 35 days postinoculation. The pattern of shedding and propensity for the upper respiratory tract infection in dromedary camels may help explain the lack of systemic illness among naturally infected camels and the means of efficient camel-to-camel and camel-to-human transmission. </div>
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   |clé=     pubmed:25418529
   |texte=   Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.
}}

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Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.

Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.

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