MersV1, PubMed, Curation, bibRecord, 001679

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus.

Identifieur interne : 001679 ( PubMed/Curation ); précédent : 001678; suivant : 001680

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus.

Auteurs : Xiaojuan Guo [République populaire de Chine] ; Yao Deng [République populaire de Chine] ; Hong Chen [République populaire de Chine] ; Jiaming Lan [République populaire de Chine] ; Wen Wang [République populaire de Chine] ; Xiaohui Zou [République populaire de Chine] ; Tao Hung [République populaire de Chine] ; Zhuozhuang Lu [République populaire de Chine] ; Wenjie Tan [République populaire de Chine]

Source :

Immunology [ 1365-2567 ] ; 2015.

RBID : pubmed:25762305

Descripteurs français

English descriptors

KwdEn :
- Adenoviridae (genetics), Adenoviridae (immunology), Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Base Sequence, Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (transmission), Humans, Immunity, Cellular, Immunity, Mucosal, Immunization, Immunoglobulin G (immunology), Mice, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Molecular Sequence Data, Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), T-Lymphocytes (immunology), Viral Vaccines (immunology).
MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- genetics : Adenoviridae, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- immunology : Adenoviridae, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, T-Lymphocytes.
- prevention & control : Coronavirus Infections.
- transmission : Coronavirus Infections.
- Animals, Base Sequence, Humans, Immunity, Cellular, Immunity, Mucosal, Immunization, Mice, Molecular Sequence Data.

Abstract

An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the in vivo systemic and mucosal antigen-specific immune responses induced by a single intramuscular or intragastric administration of recombinant adenoviral type 5 (Ad5) or type 41 (Ad41) -based vaccines expressing the MERS-CoV spike (S) protein. Intragastric administration of either Ad5-S or Ad41-S induced antigen-specific IgG and neutralizing antibody in serum; however, antigen-specific T-cell responses were not detected. In contrast, after a single intramuscular dose of Ad5-S or Ad41-S, functional antigen-specific T-cell responses were elicited in the spleen and pulmonary lymphocytes of the mice, which persisted for several months. Both rAd-based vaccines administered intramuscularly induced systemic humoral immune responses (neutralizing IgG antibodies). Our results show that a single dose of Ad5-S- or Ad41-S-based vaccines represents an appealing strategy for the control of MERS-CoV infection and transmission.

DOI: 10.1111/imm.12462
PubMed: 25762305

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<front><div type="abstract" xml:lang="en">An ideal vaccine against mucosal pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) should confer sustained, protective immunity at both systemic and mucosal levels. Here, we evaluated the in vivo systemic and mucosal antigen-specific immune responses induced by a single intramuscular or intragastric administration of recombinant adenoviral type 5 (Ad5) or type 41 (Ad41) -based vaccines expressing the MERS-CoV spike (S) protein. Intragastric administration of either Ad5-S or Ad41-S induced antigen-specific IgG and neutralizing antibody in serum; however, antigen-specific T-cell responses were not detected. In contrast, after a single intramuscular dose of Ad5-S or Ad41-S, functional antigen-specific T-cell responses were elicited in the spleen and pulmonary lymphocytes of the mice, which persisted for several months. Both rAd-based vaccines administered intramuscularly induced systemic humoral immune responses (neutralizing IgG antibodies). Our results show that a single dose of Ad5-S- or Ad41-S-based vaccines represents an appealing strategy for the control of MERS-CoV infection and transmission. </div>
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Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus.

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus.

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