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Animal models of Middle East respiratory syndrome coronavirus infection.

Identifieur interne : 001546 ( PubMed/Curation ); précédent : 001545; suivant : 001547

Animal models of Middle East respiratory syndrome coronavirus infection.

Auteurs : Neeltje Van Doremalen [États-Unis] ; Vincent J. Munster [États-Unis]

Source :

Antiviral research [ 1872-9096 ] ; 2015.

RBID : pubmed:26192750

Descripteurs français

KwdFr :
- Animaux, Callithrix, Coronavirus du syndrome respiratoire du Moyen-Orient, Cricetinae, Dipeptidyl peptidase 4 (génétique), Encéphale (anatomopathologie), Encéphale (virologie), Femelle, Humains, Infections à coronavirus (virologie), Macaca mulatta, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Souris, Souris transgéniques.
MESH :
- anatomopathologie : Encéphale, Poumon.
- génétique : Dipeptidyl peptidase 4.
- virologie : Encéphale, Infections à coronavirus, Poumon.
- Animaux, Callithrix, Coronavirus du syndrome respiratoire du Moyen-Orient, Cricetinae, Femelle, Humains, Macaca mulatta, Modèles animaux de maladie humaine, Souris, Souris transgéniques.

English descriptors

KwdEn :
- Animals, Brain (pathology), Brain (virology), Callithrix, Coronavirus Infections (virology), Cricetinae, Dipeptidyl Peptidase 4 (genetics), Disease Models, Animal, Female, Humans, Lung (pathology), Lung (virology), Macaca mulatta, Mice, Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus.
MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- pathology : Brain, Lung.
- virology : Brain, Coronavirus Infections, Lung.
- Animals, Callithrix, Cricetinae, Disease Models, Animal, Female, Humans, Macaca mulatta, Mice, Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus.

Abstract

The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. In this review, we discuss the current state of knowledge of animal models of MERS-CoV infection. Commonly used laboratory animal species such as Syrian hamsters, mice and ferrets are not susceptible to MERS-CoV, due to differences in the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4). The initially developed animal models comprise two nonhuman primate species, the rhesus macaque and the common marmoset. Rhesus macaques develop a mild to moderate respiratory disease upon inoculation, reminiscent of milder MERS cases, whereas marmosets develop a moderate to severe respiratory disease, recapitulating the severe disease observed in some patients. Dromedary camels, considered to be the reservoir for MERS-CoV, develop a mild upper respiratory tract infection with abundant viral shedding. Although normal mice are not susceptible to MERS-CoV, expression of the human DPP4 (hDPP4) overcomes the lack of susceptibility. Transgenic hDPP4 mice develop severe and lethal respiratory disease upon inoculation with MERS-CoV. These hDPP4 transgenic mice are potentially the ideal first line animal model for efficacy testing of therapeutic and prophylactic countermeasures. Further characterization of identified countermeasures would ideally be performed in the common marmoset model, due to the more severe disease outcome. This article forms part of a symposium in Antiviral Research on "From SARS to MERS: research on highly pathogenic human coronaviruses."

DOI: 10.1016/j.antiviral.2015.07.005
PubMed: 26192750

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second time that a new, highly pathogenic coronavirus has emerged in the human population in the 21st century. In this review, we discuss the current state of knowledge of animal models of MERS-CoV infection. Commonly used laboratory animal species such as Syrian hamsters, mice and ferrets are not susceptible to MERS-CoV, due to differences in the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4). The initially developed animal models comprise two nonhuman primate species, the rhesus macaque and the common marmoset. Rhesus macaques develop a mild to moderate respiratory disease upon inoculation, reminiscent of milder MERS cases, whereas marmosets develop a moderate to severe respiratory disease, recapitulating the severe disease observed in some patients. Dromedary camels, considered to be the reservoir for MERS-CoV, develop a mild upper respiratory tract infection with abundant viral shedding. Although normal mice are not susceptible to MERS-CoV, expression of the human DPP4 (hDPP4) overcomes the lack of susceptibility. Transgenic hDPP4 mice develop severe and lethal respiratory disease upon inoculation with MERS-CoV. These hDPP4 transgenic mice are potentially the ideal first line animal model for efficacy testing of therapeutic and prophylactic countermeasures. Further characterization of identified countermeasures would ideally be performed in the common marmoset model, due to the more severe disease outcome. This article forms part of a symposium in Antiviral Research on "From SARS to MERS: research on highly pathogenic human coronaviruses." </div>
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Animal models of Middle East respiratory syndrome coronavirus infection.

Animal models of Middle East respiratory syndrome coronavirus infection.

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