Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.
Identifieur interne : 001374 ( PubMed/Curation ); précédent : 001373; suivant : 001375Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.
Auteurs : Janne Tynell [Finlande] ; Veera Westenius [Finlande] ; Esa Rönkkö [Finlande] ; Vincent J. Munster [États-Unis] ; Krister Melén [Finlande] ; Pamela Österlund [Finlande] ; Ilkka Julkunen [Finlande]Source :
- The Journal of general virology [ 1465-2099 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Adulte, Cellules dendritiques (immunologie), Cellules dendritiques (virologie), Chimiokine CXCL10 (métabolisme), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Immunité innée, Macrophages (immunologie), Macrophages (virologie), Protéines de résistance aux myxovirus (métabolisme), Protéines virales (analyse), Réplication virale, Virus du SRAS (immunologie), Virus du SRAS (physiologie).
- MESH :
- analyse : ARN viral, Protéines virales.
- immunologie : Cellules dendritiques, Coronavirus du syndrome respiratoire du Moyen-Orient, Macrophages, Virus du SRAS.
- métabolisme : Chimiokine CXCL10, Protéines de résistance aux myxovirus.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- virologie : Cellules dendritiques, Macrophages.
- Adulte, Humains, Immunité innée, Réplication virale.
English descriptors
- KwdEn :
- Adult, Chemokine CXCL10 (metabolism), Dendritic Cells (immunology), Dendritic Cells (virology), Humans, Immunity, Innate, Macrophages (immunology), Macrophages (virology), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (physiology), Myxovirus Resistance Proteins (metabolism), RNA, Viral (analysis), SARS Virus (immunology), SARS Virus (physiology), Viral Proteins (analysis), Virus Replication.
- MESH :
- chemical , analysis : RNA, Viral, Viral Proteins.
- chemical , metabolism : Chemokine CXCL10, Myxovirus Resistance Proteins.
- immunology : Dendritic Cells, Macrophages, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Dendritic Cells, Macrophages.
- Adult, Humans, Immunity, Innate, Virus Replication.
Abstract
In this study we assessed the ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to replicate and induce innate immunity in human monocyte-derived macrophages and dendritic cells (MDDCs), and compared it with severe acute respiratory syndrome coronavirus (SARS-CoV). Assessments of viral protein and RNA levels in infected cells showed that both viruses were impaired in their ability to replicate in these cells. Some induction of IFN-λ1, CXCL10 and MxA mRNAs in both macrophages and MDDCs was seen in response to MERS-CoV infection, but almost no such induction was observed in response to SARS-CoV infection. ELISA and Western blot assays showed clear production of CXCL10 and MxA in MERS-CoV-infected macrophages and MDDCs. Our data suggest that SARS-CoV and MERS-CoV replicate poorly in human macrophages and MDDCs, but MERS-CoV is nonetheless capable of inducing a readily detectable host innate immune response. Our results highlight a clear difference between the viruses in activating host innate immune responses in macrophages and MDDCs, which may contribute to the pathogenesis of infection.
DOI: 10.1099/jgv.0.000351
PubMed: 26602089
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001374
Links to Exploration step
pubmed:26602089Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.</title><author><name sortKey="Tynell, Janne" sort="Tynell, Janne" uniqKey="Tynell J" first="Janne" last="Tynell">Janne Tynell</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Westenius, Veera" sort="Westenius, Veera" uniqKey="Westenius V" first="Veera" last="Westenius">Veera Westenius</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea></affiliation></author><author><name sortKey="Melen, Krister" sort="Melen, Krister" uniqKey="Melen K" first="Krister" last="Melén">Krister Melén</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Julkunen, Ilkka" sort="Julkunen, Ilkka" uniqKey="Julkunen I" first="Ilkka" last="Julkunen">Ilkka Julkunen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26602089</idno><idno type="pmid">26602089</idno><idno type="doi">10.1099/jgv.0.000351</idno><idno type="wicri:Area/PubMed/Corpus">001374</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001374</idno><idno type="wicri:Area/PubMed/Curation">001374</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001374</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.</title><author><name sortKey="Tynell, Janne" sort="Tynell, Janne" uniqKey="Tynell J" first="Janne" last="Tynell">Janne Tynell</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Westenius, Veera" sort="Westenius, Veera" uniqKey="Westenius V" first="Veera" last="Westenius">Veera Westenius</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea></affiliation></author><author><name sortKey="Melen, Krister" sort="Melen, Krister" uniqKey="Melen K" first="Krister" last="Melén">Krister Melén</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Julkunen, Ilkka" sort="Julkunen, Ilkka" uniqKey="Julkunen I" first="Ilkka" last="Julkunen">Ilkka Julkunen</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of general virology</title><idno type="eISSN">1465-2099</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Chemokine CXCL10 (metabolism)</term><term>Dendritic Cells (immunology)</term><term>Dendritic Cells (virology)</term><term>Humans</term><term>Immunity, Innate</term><term>Macrophages (immunology)</term><term>Macrophages (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Myxovirus Resistance Proteins (metabolism)</term><term>RNA, Viral (analysis)</term><term>SARS Virus (immunology)</term><term>SARS Virus (physiology)</term><term>Viral Proteins (analysis)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Adulte</term><term>Cellules dendritiques (immunologie)</term><term>Cellules dendritiques (virologie)</term><term>Chimiokine CXCL10 (métabolisme)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Humains</term><term>Immunité innée</term><term>Macrophages (immunologie)</term><term>Macrophages (virologie)</term><term>Protéines de résistance aux myxovirus (métabolisme)</term><term>Protéines virales (analyse)</term><term>Réplication virale</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemokine CXCL10</term><term>Myxovirus Resistance Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Macrophages</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term><term>Macrophages</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chimiokine CXCL10</term><term>Protéines de résistance aux myxovirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dendritic Cells</term><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Immunity, Innate</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Humains</term><term>Immunité innée</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study we assessed the ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to replicate and induce innate immunity in human monocyte-derived macrophages and dendritic cells (MDDCs), and compared it with severe acute respiratory syndrome coronavirus (SARS-CoV). Assessments of viral protein and RNA levels in infected cells showed that both viruses were impaired in their ability to replicate in these cells. Some induction of IFN-λ1, CXCL10 and MxA mRNAs in both macrophages and MDDCs was seen in response to MERS-CoV infection, but almost no such induction was observed in response to SARS-CoV infection. ELISA and Western blot assays showed clear production of CXCL10 and MxA in MERS-CoV-infected macrophages and MDDCs. Our data suggest that SARS-CoV and MERS-CoV replicate poorly in human macrophages and MDDCs, but MERS-CoV is nonetheless capable of inducing a readily detectable host innate immune response. Our results highlight a clear difference between the viruses in activating host innate immune responses in macrophages and MDDCs, which may contribute to the pathogenesis of infection. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26602089</PMID><DateCompleted><Year>2016</Year><Month>06</Month><Day>27</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1465-2099</ISSN><JournalIssue CitedMedium="Internet"><Volume>97</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of general virology</Title><ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation></Journal><ArticleTitle>Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.</ArticleTitle><Pagination><MedlinePgn>344-355</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1099/jgv.0.000351</ELocationID><Abstract><AbstractText>In this study we assessed the ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to replicate and induce innate immunity in human monocyte-derived macrophages and dendritic cells (MDDCs), and compared it with severe acute respiratory syndrome coronavirus (SARS-CoV). Assessments of viral protein and RNA levels in infected cells showed that both viruses were impaired in their ability to replicate in these cells. Some induction of IFN-λ1, CXCL10 and MxA mRNAs in both macrophages and MDDCs was seen in response to MERS-CoV infection, but almost no such induction was observed in response to SARS-CoV infection. ELISA and Western blot assays showed clear production of CXCL10 and MxA in MERS-CoV-infected macrophages and MDDCs. Our data suggest that SARS-CoV and MERS-CoV replicate poorly in human macrophages and MDDCs, but MERS-CoV is nonetheless capable of inducing a readily detectable host innate immune response. Our results highlight a clear difference between the viruses in activating host innate immune responses in macrophages and MDDCs, which may contribute to the pathogenesis of infection. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tynell</LastName><ForeName>Janne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westenius</LastName><ForeName>Veera</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rönkkö</LastName><ForeName>Esa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Munster</LastName><ForeName>Vincent J</ForeName><Initials>VJ</Initials><AffiliationInfo><Affiliation>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melén</LastName><ForeName>Krister</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Österlund</LastName><ForeName>Pamela</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Julkunen</LastName><ForeName>Ilkka</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Virology, University of Turku, Turku, Finland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Gen Virol</MedlineTA><NlmUniqueID>0077340</NlmUniqueID><ISSNLinking>0022-1317</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C114753">CXCL10 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054357">Chemokine CXCL10</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C579071">MX1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064547">Myxovirus Resistance Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054357" MajorTopicYN="N">Chemokine CXCL10</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003713" MajorTopicYN="N">Dendritic Cells</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064547" MajorTopicYN="N">Myxovirus Resistance Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="Y">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26602089</ArticleId><ArticleId IdType="doi">10.1099/jgv.0.000351</ArticleId><ArticleId IdType="pmc">PMC4804640</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation><ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2003 Aug;77(16):8801-11</Citation><ArticleIdList><ArticleId IdType="pubmed">12885899</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94</Citation><ArticleIdList><ArticleId IdType="pubmed">12892317</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2003 Nov 27;426(6965):450-4</Citation><ArticleIdList><ArticleId IdType="pubmed">14647384</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1993 Mar 1;150(5):1715-26</Citation><ArticleIdList><ArticleId IdType="pubmed">7679692</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Exp Med Biol. 1998;440:635-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9782339</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1999 Jun 15;162(12):7322-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10358182</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Feb;79(4):2079-86</Citation><ArticleIdList><ArticleId IdType="pubmed">15681410</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Aug;79(15):9608-17</Citation><ArticleIdList><ArticleId IdType="pubmed">16014923</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2005 Oct 1;106(7):2366-74</Citation><ArticleIdList><ArticleId IdType="pubmed">15860669</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Nov;79(21):13800-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16227300</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):548-57</Citation><ArticleIdList><ArticleId IdType="pubmed">17108024</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2007 Sep;82(3):710-20</Citation><ArticleIdList><ArticleId IdType="pubmed">17595377</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Sep;81(18):9812-24</Citation><ArticleIdList><ArticleId IdType="pubmed">17596301</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2007 Oct;20(4):660-94</Citation><ArticleIdList><ArticleId IdType="pubmed">17934078</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2009 Jun 12;284(24):16202-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19380580</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009;4(12):e8342</Citation><ArticleIdList><ArticleId IdType="pubmed">20020050</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Feb;84(3):1414-22</Citation><ArticleIdList><ArticleId IdType="pubmed">19939920</ArticleId></ArticleIdList></Reference><Reference><Citation>Retrovirology. 2010;7:31</Citation><ArticleIdList><ArticleId IdType="pubmed">20374633</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2011 Nov;7(11):e1002345</Citation><ArticleIdList><ArticleId IdType="pubmed">22072965</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2012 Mar;93(Pt 3):494-503</Citation><ArticleIdList><ArticleId IdType="pubmed">22090214</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2012;17(39). pii: 20285</Citation><ArticleIdList><ArticleId IdType="pubmed">23041020</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2012 Nov;93(Pt 11):2315-25</Citation><ArticleIdList><ArticleId IdType="pubmed">22894921</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2013 Jan;62(1):149-57</Citation><ArticleIdList><ArticleId IdType="pubmed">22936179</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 May;87(9):5300-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23449793</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 May;87(10):5502-11</Citation><ArticleIdList><ArticleId IdType="pubmed">23468491</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2013 Jun 1;207(11):1743-52</Citation><ArticleIdList><ArticleId IdType="pubmed">23532101</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2013;4(3):e00165-13</Citation><ArticleIdList><ArticleId IdType="pubmed">23631916</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation><ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2013 Oct;19(10):1697-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24050621</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2013 Oct;13(10):859-66</Citation><ArticleIdList><ArticleId IdType="pubmed">23933067</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Nov;87(22):12489-95</Citation><ArticleIdList><ArticleId IdType="pubmed">24027320</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Dec;87(23):12552-61</Citation><ArticleIdList><ArticleId IdType="pubmed">24027332</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2013 Nov;19(11):1819-23</Citation><ArticleIdList><ArticleId IdType="pubmed">24206838</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2013 Dec;94(Pt 12):2679-90</Citation><ArticleIdList><ArticleId IdType="pubmed">24077366</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Cell. 2013 Dec;4(12):951-61</Citation><ArticleIdList><ArticleId IdType="pubmed">24318862</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2014 Feb;14(2):140-5</Citation><ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2014 Mar;95(Pt 3):614-26</Citation><ArticleIdList><ArticleId IdType="pubmed">24362959</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014;9(2):e88716</Citation><ArticleIdList><ArticleId IdType="pubmed">24551142</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2014 Apr;20(4):552-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24655412</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2014 Apr;95(Pt 4):874-82</Citation><ArticleIdList><ArticleId IdType="pubmed">24443473</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Pulm Med. 2014 May;20(3):233-41</Citation><ArticleIdList><ArticleId IdType="pubmed">24626235</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 May;88(9):4866-76</Citation><ArticleIdList><ArticleId IdType="pubmed">24522921</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2014 Apr;454-455:197-205</Citation><ArticleIdList><ArticleId IdType="pubmed">24725946</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2014 Jun 26;370(26):2499-505</Citation><ArticleIdList><ArticleId IdType="pubmed">24896817</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2014 Aug;20(8):1370-4</Citation><ArticleIdList><ArticleId IdType="pubmed">25062254</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Aug;88(16):9220-32</Citation><ArticleIdList><ArticleId IdType="pubmed">24899185</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2014 Aug;20(8):1339-42</Citation><ArticleIdList><ArticleId IdType="pubmed">25075761</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Oct;88(19):11297-303</Citation><ArticleIdList><ArticleId IdType="pubmed">25031349</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2014 Sep 10;16(3):328-37</Citation><ArticleIdList><ArticleId IdType="pubmed">25211075</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2014 Oct;61(2):275-8</Citation><ArticleIdList><ArticleId IdType="pubmed">25073585</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15214-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25288733</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2014 Nov;10(11):e1004502</Citation><ArticleIdList><ArticleId IdType="pubmed">25375324</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2014 Dec;20(12):1999-2005</Citation><ArticleIdList><ArticleId IdType="pubmed">25418529</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2014 Dec 19;194:124-37</Citation><ArticleIdList><ArticleId IdType="pubmed">25093995</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2015 Jan;16(1):36-44</Citation><ArticleIdList><ArticleId IdType="pubmed">25521683</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2015 Apr;89(7):3859-69</Citation><ArticleIdList><ArticleId IdType="pubmed">25609809</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001374 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001374 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:26602089
|texte= Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:26602089" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |