Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients.
Identifieur interne : 001315 ( PubMed/Curation ); précédent : 001314; suivant : 001316Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients.
Auteurs : Ashraf Abdel Halim [Égypte] ; Badr Alsayed [Arabie saoudite] ; Sameh Embarak [Égypte] ; Taha Yaseen [Inde] ; Salwa Dabbous [Égypte]Source :
- The Egyptian journal of chest diseases and tuberculosis [ 0422-7638 ] ; 2016.
Abstract
Middle East Respiratory Syndrome (MERS) is a novel respiratory illness firstly reported in Saudi Arabia in 2012. It is caused by a new corona virus, called MERS corona virus (MERS-CoV). Most people who have MERS-CoV infection developed severe acute respiratory illness.
DOI: 10.1016/j.ejcdt.2015.11.011
PubMed: 32288128
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sortKey="Embarak, Sameh" sort="Embarak, Sameh" uniqKey="Embarak S" first="Sameh" last="Embarak">Sameh Embarak</name><affiliation wicri:level="1"><nlm:affiliation>Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Chest Department, Faculty of Medicine, Zagazig University, Zagazig</wicri:regionArea></affiliation></author><author><name sortKey="Yaseen, Taha" sort="Yaseen, Taha" uniqKey="Yaseen T" first="Taha" last="Yaseen">Taha Yaseen</name><affiliation wicri:level="1"><nlm:affiliation>ICU Department, Patna University, Patna, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICU Department, Patna University, Patna</wicri:regionArea></affiliation></author><author><name sortKey="Dabbous, Salwa" sort="Dabbous, Salwa" uniqKey="Dabbous S" first="Salwa" last="Dabbous">Salwa Dabbous</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pathology Department, 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Abdel" uniqKey="Halim A" first="Ashraf Abdel" last="Halim">Ashraf Abdel Halim</name><affiliation wicri:level="1"><nlm:affiliation>Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Chest Department, Faculty of Medicine, Zagazig University, Zagazig</wicri:regionArea></affiliation></author><author><name sortKey="Alsayed, Badr" sort="Alsayed, Badr" uniqKey="Alsayed B" first="Badr" last="Alsayed">Badr Alsayed</name><affiliation wicri:level="1"><nlm:affiliation>Tabuk University, Tabuk, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Tabuk University, Tabuk</wicri:regionArea></affiliation></author><author><name sortKey="Embarak, Sameh" sort="Embarak, Sameh" uniqKey="Embarak S" first="Sameh" last="Embarak">Sameh Embarak</name><affiliation wicri:level="1"><nlm:affiliation>Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Chest Department, Faculty of Medicine, Zagazig University, Zagazig</wicri:regionArea></affiliation></author><author><name sortKey="Yaseen, Taha" sort="Yaseen, Taha" uniqKey="Yaseen T" first="Taha" last="Yaseen">Taha Yaseen</name><affiliation wicri:level="1"><nlm:affiliation>ICU Department, Patna University, Patna, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>ICU Department, Patna University, Patna</wicri:regionArea></affiliation></author><author><name sortKey="Dabbous, Salwa" sort="Dabbous, Salwa" uniqKey="Dabbous S" first="Salwa" last="Dabbous">Salwa Dabbous</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Egyptian journal of chest diseases and tuberculosis</title><idno type="ISSN">0422-7638</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East Respiratory Syndrome (MERS) is a novel respiratory illness firstly reported in Saudi Arabia in 2012. It is caused by a new corona virus, called MERS corona virus (MERS-CoV). Most people who have MERS-CoV infection developed severe acute respiratory illness.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32288128</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0422-7638</ISSN><JournalIssue CitedMedium="Print"><Volume>65</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Egyptian journal of chest diseases and tuberculosis</Title><ISOAbbreviation>Egypt J Chest Dis Tuberc</ISOAbbreviation></Journal><ArticleTitle>Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients.</ArticleTitle><Pagination><MedlinePgn>81-87</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejcdt.2015.11.011</ELocationID><Abstract><AbstractText>Middle East Respiratory Syndrome (MERS) is a novel respiratory illness firstly reported in Saudi Arabia in 2012. It is caused by a new corona virus, called MERS corona virus (MERS-CoV). Most people who have MERS-CoV infection developed severe acute respiratory illness.</AbstractText><AbstractText Label="Aim of the work" NlmCategory="UNASSIGNED">This work is done to determine the clinical characteristics and the outcome of intensive care unit (ICU) admitted patients with confirmed MERS-CoV infection.</AbstractText><AbstractText Label="Patients and methods" NlmCategory="UNASSIGNED">This study included 32 laboratory confirmed MERS corona virus infected patients who were admitted into ICU. It included 20 (62.50%) males and 12 (37.50%) females. The mean age was 43.99 ± 13.03 years. Diagnosis was done by real-time reverse transcription polymerase chain reaction (rRT-PCR) test for corona virus on throat swab, sputum, tracheal aspirate, or bronchoalveolar lavage specimens. Clinical characteristics, co-morbidities and outcome were reported for all subjects.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">The main symptoms among the included patients were: fever (96.87%), cough (93.75%), dyspnea (90.62%), sore throat (75%), runny nose (75%), sputum (50%), headache (43.75%), myalgia (40.62%), chest pain (37.50%), hemoptysis (37.50%), nausea and vomiting (34.37%), abdominal pain (21.87%) and diarrhea (15.62%). The presence of abdominal symptoms is significantly (<i>P</i> < 0.05) associated with bad prognosis. Out of the included 32 patients, 18 patients (56.25%) survived and 14 patients (43.75%) expired. There was a statistically significant difference in the duration of symptoms before hospitalization, mechanical ventilation and ICU and total hospital stay between the expired group and survivors (<i>P</i> < 0.01). Current smoking and smoking severity were statistically significantly (<i>P</i> < 0.01) higher in the expired group compared to survivors. Also, there was a statistically (<i>P</i> < 0.05) significant positive correlation between mortality and smoking severity (<i>r</i> = 0.640). Most of the expired patients presented with bilateral pulmonary infiltrates or unilateral infiltrates, but most of the survivors presented with normal radiology or increased bronchovascular markings, and this difference in the results was statistically highly significant (<i>P</i> < 0.01). There were statistically highly significant (<i>P</i> < 0.01) differences in the mean values of APACHE II score (21.11 ± 3.70 vs 24.21 ± 3.82), SOFA score (5.83 ± 2.64 vs 8.85 ± 2.17) and CPIS (7.55 ± 1.14 vs 8.64 ± 1.39) between the expired group and survivors respectively. Also, there was a statistically significant decrease in PH, PaO<sub>2</sub>, O<sub>2</sub> saturation and HCO<sub>3</sub> (<i>P</i> < 0.05) among the expired group in comparison with the survivors, but no statistical difference regarding PaCO<sub>2</sub> (<i>P</i> > 0.05). There was a statistically significant positive correlation between mortality and old age (<i>r</i> = 0.633), obesity (<i>r</i> = 0.712), diabetes mellitus (<i>r</i> = 0.685), renal failure (<i>r</i> = 0.705), chronic heart diseases (0.591), COPD (<i>r</i> = 0.523), malignancy (<i>r</i> = 0.692), kidney transplantation (<i>r</i> = 0.644) and liver cirrhosis (<i>r</i> = 0.525) (<i>P</i> < 0.05). There was a statistically (<i>P</i> < 0.05) positive correlation between the number of associated co-morbidities and mortality (<i>r</i> = 0.735).</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Most MERS corona patients present with fever, cough, dyspnea, sore throat, runny nose and sputum. The presence of abdominal symptoms may indicate bad prognosis. Prolonged duration of symptoms before patients' hospitalization, prolonged duration of mechanical ventilation and hospital stay, bilateral radiological pulmonary infiltrates, and hypoxemic respiratory failure were found to be strong predictors of mortality in such patients. Also, old age, current smoking, smoking severity, presence of associated co-morbidities like obesity, diabetes mellitus, chronic heart diseases, COPD, malignancy, renal failure, renal transplantation and liver cirrhosis are associated with a poor outcome of ICU admitted MERS corona virus infected patients.</AbstractText><CopyrightInformation>© 2015 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Halim</LastName><ForeName>Ashraf Abdel</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsayed</LastName><ForeName>Badr</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Tabuk University, Tabuk, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Embarak</LastName><ForeName>Sameh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yaseen</LastName><ForeName>Taha</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>ICU Department, Patna University, Patna, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dabbous</LastName><ForeName>Salwa</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Egypt</Country><MedlineTA>Egypt J Chest Dis Tuberc</MedlineTA><NlmUniqueID>9892259</NlmUniqueID><ISSNLinking>0422-7638</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Clinical characteristics</Keyword><Keyword MajorTopicYN="N">Corona virus</Keyword><Keyword MajorTopicYN="N">MERS</Keyword><Keyword MajorTopicYN="N">Outcome</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32288128</ArticleId><ArticleId IdType="doi">10.1016/j.ejcdt.2015.11.011</ArticleId><ArticleId IdType="pii">S0422-7638(15)30119-9</ArticleId><ArticleId IdType="pmc">PMC7132710</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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