MersV1, PubMed, Curation, bibRecord, 001137

Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission.

Identifieur interne : 001137 ( PubMed/Curation ); précédent : 001136; suivant : 001138

Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission.

Auteurs : Zhao Zhang [République populaire de Chine] ; Libing Shen [République populaire de Chine] ; Xun Gu [République populaire de Chine]

Source :

Scientific reports [ 2045-2322 ] ; 2016.

RBID : pubmed:27142087

Descripteurs français

KwdFr :
- Animaux, Biologie informatique, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Humains, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (transmission), Infections à coronavirus (virologie), Phylogénie, Recombinaison génétique, Sélection génétique, Variation génétique, Évolution moléculaire.
MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Animaux, Biologie informatique, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Infections à coronavirus, Phylogénie, Recombinaison génétique, Sélection génétique, Variation génétique, Évolution moléculaire.

English descriptors

KwdEn :
- Animals, Computational Biology, Coronavirus Infections (transmission), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Evolution, Molecular, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Phylogeny, Recombination, Genetic, Selection, Genetic.
MESH :
- classification : Middle East Respiratory Syndrome Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections.
- veterinary : Coronavirus Infections.
- virology : Coronavirus Infections.
- Animals, Computational Biology, Evolution, Molecular, Genetic Variation, Humans, Phylogeny, Recombination, Genetic, Selection, Genetic.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to beta group of coronavirus and was first discovered in 2012. MERS-CoV can infect multiple host species and cause severe diseases in human. We conducted a series of phylogenetic and bioinformatic analyses to study the evolution dynamics of MERS-CoV among different host species with genomic data. Our analyses show: 1) 28 potential recombinant sequences were detected and they can be classified into seven potential recombinant types; 2) The spike (S) protein of MERS-CoV was under strong positive selection when MERS-CoV transmitted from their natural host to human; 3) Six out of nine positive selection sites detected in spike (S) protein are located in its receptor-binding domain which is in direct contact with host cells; 4) MERS-CoV frequently transmitted back and forth between human and camel after it had acquired the human-camel infection capability. Together, these results suggest that potential recombination events might have happened frequently during MERS-CoV's evolutionary history and the positive selection sites in MERS-CoV's S protein might enable it to infect human.

DOI: 10.1038/srep25049
PubMed: 27142087

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Le document en format XML

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<ArticleIdList><ArticleId IdType="pubmed">9847317</ArticleId>
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</ReferenceList>
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{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:27142087
   |texte=   Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission.
}}

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Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission.

Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission.

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