HTCC: Broad Range Inhibitor of Coronavirus Entry.
Identifieur interne : 001099 ( PubMed/Curation ); précédent : 001098; suivant : 001100HTCC: Broad Range Inhibitor of Coronavirus Entry.
Auteurs : Aleksandra Milewska [Pologne] ; Kamil Kaminski [Pologne] ; Justyna Ciejka [Pologne] ; Katarzyna Kosowicz [Pologne] ; Slawomir Zeglen [Pologne] ; Jacek Wojarski [Pologne] ; Maria Nowakowska [Pologne] ; Krzysztof Szczubiałka [Pologne] ; Krzysztof Pyrc [Pologne]Source :
- PloS one [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Chitosane.
- pharmacologie : Antiviraux, Chitosane, Composés d'ammonium quaternaire.
- physiologie : Coronavirus.
- Animaux, Coronavirus, Fusion membranaire, Humains, Lignée cellulaire, Macaca mulatta, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Cell Line, Chitosan (analogs & derivatives), Chitosan (pharmacology), Coronavirus (drug effects), Coronavirus (physiology), Humans, Macaca mulatta, Membrane Fusion (drug effects), Quaternary Ammonium Compounds (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Chitosan.
- chemical , pharmacology : Antiviral Agents, Chitosan, Quaternary Ammonium Compounds.
- drug effects : Coronavirus, Membrane Fusion, Virus Replication.
- physiology : Coronavirus.
- Animals, Cell Line, Humans, Macaca mulatta.
Abstract
To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses.
DOI: 10.1371/journal.pone.0156552
PubMed: 27249425
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001099
Links to Exploration step
pubmed:27249425Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HTCC: Broad Range Inhibitor of Coronavirus Entry.</title><author><name sortKey="Milewska, Aleksandra" sort="Milewska, Aleksandra" uniqKey="Milewska A" first="Aleksandra" last="Milewska">Aleksandra Milewska</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Kaminski, Kamil" sort="Kaminski, Kamil" uniqKey="Kaminski K" first="Kamil" last="Kaminski">Kamil Kaminski</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Ciejka, Justyna" sort="Ciejka, Justyna" uniqKey="Ciejka J" first="Justyna" last="Ciejka">Justyna Ciejka</name><affiliation wicri:level="1"><nlm:affiliation>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Kosowicz, Katarzyna" sort="Kosowicz, Katarzyna" uniqKey="Kosowicz K" first="Katarzyna" last="Kosowicz">Katarzyna Kosowicz</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Zeglen, Slawomir" sort="Zeglen, Slawomir" uniqKey="Zeglen S" first="Slawomir" last="Zeglen">Slawomir Zeglen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea></affiliation></author><author><name sortKey="Wojarski, Jacek" sort="Wojarski, Jacek" uniqKey="Wojarski J" first="Jacek" last="Wojarski">Jacek Wojarski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea></affiliation></author><author><name sortKey="Nowakowska, Maria" sort="Nowakowska, Maria" uniqKey="Nowakowska M" first="Maria" last="Nowakowska">Maria Nowakowska</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Szczubialka, Krzysztof" sort="Szczubialka, Krzysztof" uniqKey="Szczubialka K" first="Krzysztof" last="Szczubiałka">Krzysztof Szczubiałka</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27249425</idno><idno type="pmid">27249425</idno><idno type="doi">10.1371/journal.pone.0156552</idno><idno type="wicri:Area/PubMed/Corpus">001099</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001099</idno><idno type="wicri:Area/PubMed/Curation">001099</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001099</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HTCC: Broad Range Inhibitor of Coronavirus Entry.</title><author><name sortKey="Milewska, Aleksandra" sort="Milewska, Aleksandra" uniqKey="Milewska A" first="Aleksandra" last="Milewska">Aleksandra Milewska</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Kaminski, Kamil" sort="Kaminski, Kamil" uniqKey="Kaminski K" first="Kamil" last="Kaminski">Kamil Kaminski</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Ciejka, Justyna" sort="Ciejka, Justyna" uniqKey="Ciejka J" first="Justyna" last="Ciejka">Justyna Ciejka</name><affiliation wicri:level="1"><nlm:affiliation>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Kosowicz, Katarzyna" sort="Kosowicz, Katarzyna" uniqKey="Kosowicz K" first="Katarzyna" last="Kosowicz">Katarzyna Kosowicz</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Zeglen, Slawomir" sort="Zeglen, Slawomir" uniqKey="Zeglen S" first="Slawomir" last="Zeglen">Slawomir Zeglen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea></affiliation></author><author><name sortKey="Wojarski, Jacek" sort="Wojarski, Jacek" uniqKey="Wojarski J" first="Jacek" last="Wojarski">Jacek Wojarski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea></affiliation></author><author><name sortKey="Nowakowska, Maria" sort="Nowakowska, Maria" uniqKey="Nowakowska M" first="Maria" last="Nowakowska">Maria Nowakowska</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Szczubialka, Krzysztof" sort="Szczubialka, Krzysztof" uniqKey="Szczubialka K" first="Krzysztof" last="Szczubiałka">Krzysztof Szczubiałka</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea></affiliation></author><author><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><affiliation wicri:level="1"><nlm:affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line</term><term>Chitosan (analogs & derivatives)</term><term>Chitosan (pharmacology)</term><term>Coronavirus (drug effects)</term><term>Coronavirus (physiology)</term><term>Humans</term><term>Macaca mulatta</term><term>Membrane Fusion (drug effects)</term><term>Quaternary Ammonium Compounds (pharmacology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Chitosane (analogues et dérivés)</term><term>Chitosane (pharmacologie)</term><term>Composés d'ammonium quaternaire (pharmacologie)</term><term>Coronavirus ()</term><term>Coronavirus (physiologie)</term><term>Fusion membranaire ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Macaca mulatta</term><term>Réplication virale ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chitosan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Chitosan</term><term>Quaternary Ammonium Compounds</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Chitosane</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term><term>Membrane Fusion</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Chitosane</term><term>Composés d'ammonium quaternaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Macaca mulatta</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Fusion membranaire</term><term>Humains</term><term>Lignée cellulaire</term><term>Macaca mulatta</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27249425</PMID><DateCompleted><Year>2017</Year><Month>07</Month><Day>18</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>6</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>HTCC: Broad Range Inhibitor of Coronavirus Entry.</ArticleTitle><Pagination><MedlinePgn>e0156552</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0156552</ELocationID><Abstract><AbstractText>To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Milewska</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaminski</LastName><ForeName>Kamil</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciejka</LastName><ForeName>Justyna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kosowicz</LastName><ForeName>Katarzyna</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeglen</LastName><ForeName>Slawomir</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wojarski</LastName><ForeName>Jacek</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowakowska</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szczubiałka</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pyrc</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C550160">N-(2-hydroxypropyl)-3-trimethylammonium chitosan</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000644">Quaternary Ammonium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>9012-76-4</RegistryNumber><NameOfSubstance UI="D048271">Chitosan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048271" MajorTopicYN="N">Chitosan</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008561" MajorTopicYN="N">Membrane Fusion</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000644" MajorTopicYN="N">Quaternary Ammonium Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>05</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27249425</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0156552</ArticleId><ArticleId IdType="pii">PONE-D-16-11003</ArticleId><ArticleId IdType="pmc">PMC4889042</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2003 Dec;1(3):209-18</Citation><ArticleIdList><ArticleId IdType="pubmed">15035025</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2001 Dec;18(6):553-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11738343</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol J. 2008 Sep 26;5:107</Citation><ArticleIdList><ArticleId IdType="pubmed">18817582</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2006 Dec 15;364(5):964-73</Citation><ArticleIdList><ArticleId IdType="pubmed">17054987</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2005 Aug;2(8):e240</Citation><ArticleIdList><ArticleId IdType="pubmed">16104827</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Apr;81(7):3051-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17079323</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367 (19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Nov;88(22):13221-30</Citation><ArticleIdList><ArticleId IdType="pubmed">25187545</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Jan;79(2):884-95</Citation><ArticleIdList><ArticleId IdType="pubmed">15613317</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 May 31;102(22):7988-93</Citation><ArticleIdList><ArticleId IdType="pubmed">15897467</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomacromolecules. 2006 Dec;7(12):3548</Citation><ArticleIdList><ArticleId IdType="pubmed">17154488</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2010 May 27;53(10):4141-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20423087</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1990 May;176(1):274-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2158693</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2011 Nov;7(11):e1002332</Citation><ArticleIdList><ArticleId IdType="pubmed">22072961</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunopharmacol Immunotoxicol. 2009 Jun;31(2):202-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19514994</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Ther Med. 2016 Apr;11(4):1300-1306</Citation><ArticleIdList><ArticleId IdType="pubmed">27073440</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurosci Lett. 2002 Mar 15;321(1-2):105-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11872267</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Med. 2010 Mar;25(3):433-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20127049</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2004 Aug;25(17):3725-32</Citation><ArticleIdList><ArticleId IdType="pubmed">15020148</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation><ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Pharm. 2002 Mar 20;235(1-2):121-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11879747</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Nov;84(21):11255-63</Citation><ArticleIdList><ArticleId IdType="pubmed">20719951</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2013 Feb;97(2):112-21</Citation><ArticleIdList><ArticleId IdType="pubmed">23201315</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioresour Technol. 2003 Jul;88(3):179-84</Citation><ArticleIdList><ArticleId IdType="pubmed">12618038</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2010 Dec 14;5(12):e14320</Citation><ArticleIdList><ArticleId IdType="pubmed">21179403</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mater Sci Mater Med. 2008 Mar;19(3):1083-90</Citation><ArticleIdList><ArticleId IdType="pubmed">17701312</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 Dec 18;349(25):2431-41</Citation><ArticleIdList><ArticleId IdType="pubmed">14681510</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 1999 Nov;20(22):2139-45</Citation><ArticleIdList><ArticleId IdType="pubmed">10555081</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2011 Nov;92(2):237-46</Citation><ArticleIdList><ArticleId IdType="pubmed">21867732</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001099 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001099 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27249425
|texte= HTCC: Broad Range Inhibitor of Coronavirus Entry.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27249425" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |