Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus.
Identifieur interne : 001093 ( PubMed/Curation ); précédent : 001092; suivant : 001094Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus.
Auteurs : Anurodh Shankar Agrawal [États-Unis] ; Xinrong Tao [États-Unis] ; Abdullah Algaissi [États-Unis] ; Tania Garron [États-Unis] ; Krishna Narayanan [États-Unis] ; Bi-Hung Peng [États-Unis] ; Robert B. Couch [États-Unis] ; Chien-Te K. Tseng [États-Unis]Source :
- Human vaccines & immunotherapeutics [ 2164-554X ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Hypersensibilité (anatomopathologie), Infections à coronavirus (), Infections à coronavirus (anatomopathologie), Poumon (anatomopathologie), Souris transgéniques, Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Vaccins inactivés (administration et posologie), Vaccins inactivés (effets indésirables), Vaccins inactivés (immunologie).
- MESH :
- administration et posologie : Vaccins antiviraux, Vaccins inactivés.
- anatomopathologie : Hypersensibilité, Infections à coronavirus, Poumon.
- effets indésirables : Vaccins inactivés.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Vaccins antiviraux, Vaccins inactivés.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- Animaux, Infections à coronavirus, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Coronavirus Infections (pathology), Coronavirus Infections (prevention & control), Hypersensitivity (pathology), Lung (pathology), Mice, Transgenic, Middle East Respiratory Syndrome Coronavirus (immunology), Vaccines, Inactivated (administration & dosage), Vaccines, Inactivated (adverse effects), Vaccines, Inactivated (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, Inactivated, Viral Vaccines.
- chemical , adverse effects : Vaccines, Inactivated.
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- immunology : Middle East Respiratory Syndrome Coronavirus, Vaccines, Inactivated, Viral Vaccines.
- pathology : Coronavirus Infections, Hypersensitivity, Lung.
- prevention & control : Coronavirus Infections.
- Animals, Mice, Transgenic.
Abstract
To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.
DOI: 10.1080/21645515.2016.1177688
PubMed: 27269431
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<front><div type="abstract" xml:lang="en">To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.</div>
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<Abstract><AbstractText>To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.</AbstractText>
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