MersV1, PubMed, Curation, bibRecord, 001001

Link of a ubiquitous human coronavirus to dromedary camels.

Identifieur interne : 001001 ( PubMed/Curation ); précédent : 001000; suivant : 001002

Link of a ubiquitous human coronavirus to dromedary camels.

Auteurs : Victor M. Corman [Allemagne] ; Isabella Eckerle [Allemagne] ; Ziad A. Memish ; Anne M. Liljander [Kenya] ; Ronald Dijkman [Suisse] ; Hulda Jonsdottir [Suisse] ; Kisi J Z. Juma Ngeiywa [Kenya] ; Esther Kamau [Kenya] ; Mario Younan [Kenya] ; Malakita Al Masri ; Abdullah Assiri ; Ilona Gluecks [Kenya] ; Bakri E. Musa [Soudan] ; Benjamin Meyer [Allemagne] ; Marcel A. Müller [Allemagne] ; Mosaad Hilali [Égypte] ; Set Bornstein [Suède] ; Ulrich Wernery [Émirats arabes unis] ; Volker Thiel [Suisse] ; Joerg Jores [Suisse] ; Jan Felix Drexler [Allemagne] ; Christian Drosten [Allemagne]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2016.

RBID : pubmed:27528677

Descripteurs français

KwdFr :
- Animaux, Arabie saoudite (épidémiologie), Cellules Caco-2, Cellules Vero, Cellules cultivées, Chameaux (virologie), Coronavirus (), Coronavirus (génétique), Coronavirus (physiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Kenya (épidémiologie), Lignée cellulaire, Lignée cellulaire tumorale, Maladies endémiques, Phylogénie, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
MESH :
- génétique : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- physiologie : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Chameaux, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infections à coronavirus, Kenya.
- Animaux, Cellules Caco-2, Cellules Vero, Cellules cultivées, Coronavirus, Humains, Lignée cellulaire, Lignée cellulaire tumorale, Maladies endémiques, Phylogénie, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
Wicri :
- geographic : Kenya, Arabie saoudite.

English descriptors

KwdEn :
- Animals, Base Sequence, Caco-2 Cells, Camelus (virology), Cell Line, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Coronavirus (classification), Coronavirus (genetics), Coronavirus (physiology), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Endemic Diseases, Humans, Kenya (epidemiology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Phylogeny, Saudi Arabia (epidemiology), Sequence Homology, Nucleic Acid, Vero Cells.
MESH :
- geographic , epidemiology : Kenya, Saudi Arabia.
- classification : Coronavirus.
- epidemiology : Coronavirus Infections.
- genetics : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- physiology : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- virology : Camelus, Coronavirus Infections.
- Animals, Base Sequence, Caco-2 Cells, Cell Line, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Endemic Diseases, Humans, Phylogeny, Sequence Homology, Nucleic Acid, Vero Cells.

Abstract

The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.

DOI: 10.1073/pnas.1604472113
PubMed: 27528677

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Ziad A. Memish

<affiliation><nlm:affiliation>College of Medicine, Alfaisal University, 11533 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
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Malakita Al Masri

<affiliation><nlm:affiliation>Ministry of Health, 11176 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>

Abdullah Assiri

<affiliation><nlm:affiliation>Ministry of Health, 11176 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>

Le document en format XML

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<country xml:lang="fr">Suisse</country>
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<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
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<term>Base Sequence</term>
<term>Caco-2 Cells</term>
<term>Camelus (virology)</term>
<term>Cell Line</term>
<term>Cell Line, Tumor</term>
<term>Cells, Cultured</term>
<term>Chlorocebus aethiops</term>
<term>Coronavirus (classification)</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Endemic Diseases</term>
<term>Humans</term>
<term>Kenya (epidemiology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Phylogeny</term>
<term>Saudi Arabia (epidemiology)</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Vero Cells</term>
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<term>Arabie saoudite (épidémiologie)</term>
<term>Cellules Caco-2</term>
<term>Cellules Vero</term>
<term>Cellules cultivées</term>
<term>Chameaux (virologie)</term>
<term>Coronavirus ()</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (physiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Humains</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Kenya (épidémiologie)</term>
<term>Lignée cellulaire</term>
<term>Lignée cellulaire tumorale</term>
<term>Maladies endémiques</term>
<term>Phylogénie</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence nucléotidique</term>
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<term>Infections à coronavirus</term>
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<term>Coronavirus Infections</term>
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<front><div type="abstract" xml:lang="en">The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.</div>
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<DateCompleted><Year>2018</Year>
<Month>03</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>113</Volume>
<Issue>35</Issue>
<PubDate><Year>2016</Year>
<Month>08</Month>
<Day>30</Day>
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<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
</Journal>
<ArticleTitle>Link of a ubiquitous human coronavirus to dromedary camels.</ArticleTitle>
<Pagination><MedlinePgn>9864-9</MedlinePgn>
</Pagination>
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<Abstract><AbstractText>The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.</AbstractText>
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<ForeName>Victor M</ForeName>
<Initials>VM</Initials>
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<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany;</Affiliation>
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<ForeName>Ziad A</ForeName>
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<Initials>R</Initials>
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<ForeName>Ilona</ForeName>
<Initials>I</Initials>
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</AffiliationInfo>
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<ForeName>Bakri E</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meyer</LastName>
<ForeName>Benjamin</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Müller</LastName>
<ForeName>Marcel A</ForeName>
<Initials>MA</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hilali</LastName>
<ForeName>Mosaad</ForeName>
<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Bornstein</LastName>
<ForeName>Set</ForeName>
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<ForeName>Ulrich</ForeName>
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</Author>
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<ForeName>Volker</ForeName>
<Initials>V</Initials>
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</AffiliationInfo>
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<ForeName>Joerg</ForeName>
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<AffiliationInfo><Affiliation>International Livestock Research Institute, Nairobi, Kenya; Institute of Veterinary Bacteriology, University of Bern, 3001 Bern, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drexler</LastName>
<ForeName>Jan Felix</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drosten</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</Affiliation>
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Link of a ubiquitous human coronavirus to dromedary camels.

Link of a ubiquitous human coronavirus to dromedary camels.

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