Link of a ubiquitous human coronavirus to dromedary camels.
Identifieur interne : 001001 ( PubMed/Curation ); précédent : 001000; suivant : 001002Link of a ubiquitous human coronavirus to dromedary camels.
Auteurs : Victor M. Corman [Allemagne] ; Isabella Eckerle [Allemagne] ; Ziad A. Memish ; Anne M. Liljander [Kenya] ; Ronald Dijkman [Suisse] ; Hulda Jonsdottir [Suisse] ; Kisi J Z. Juma Ngeiywa [Kenya] ; Esther Kamau [Kenya] ; Mario Younan [Kenya] ; Malakita Al Masri ; Abdullah Assiri ; Ilona Gluecks [Kenya] ; Bakri E. Musa [Soudan] ; Benjamin Meyer [Allemagne] ; Marcel A. Müller [Allemagne] ; Mosaad Hilali [Égypte] ; Set Bornstein [Suède] ; Ulrich Wernery [Émirats arabes unis] ; Volker Thiel [Suisse] ; Joerg Jores [Suisse] ; Jan Felix Drexler [Allemagne] ; Christian Drosten [Allemagne]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Arabie saoudite (épidémiologie), Cellules Caco-2, Cellules Vero, Cellules cultivées, Chameaux (virologie), Coronavirus (), Coronavirus (génétique), Coronavirus (physiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Kenya (épidémiologie), Lignée cellulaire, Lignée cellulaire tumorale, Maladies endémiques, Phylogénie, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
- MESH :
- génétique : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- physiologie : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Chameaux, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infections à coronavirus, Kenya.
- Animaux, Cellules Caco-2, Cellules Vero, Cellules cultivées, Coronavirus, Humains, Lignée cellulaire, Lignée cellulaire tumorale, Maladies endémiques, Phylogénie, Similitude de séquences d'acides nucléiques, Séquence nucléotidique.
- Wicri :
- geographic : Kenya, Arabie saoudite.
English descriptors
- KwdEn :
- Animals, Base Sequence, Caco-2 Cells, Camelus (virology), Cell Line, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Coronavirus (classification), Coronavirus (genetics), Coronavirus (physiology), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Endemic Diseases, Humans, Kenya (epidemiology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), Phylogeny, Saudi Arabia (epidemiology), Sequence Homology, Nucleic Acid, Vero Cells.
- MESH :
- geographic , epidemiology : Kenya, Saudi Arabia.
- classification : Coronavirus.
- epidemiology : Coronavirus Infections.
- genetics : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- physiology : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- virology : Camelus, Coronavirus Infections.
- Animals, Base Sequence, Caco-2 Cells, Cell Line, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Endemic Diseases, Humans, Phylogeny, Sequence Homology, Nucleic Acid, Vero Cells.
Abstract
The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.
DOI: 10.1073/pnas.1604472113
PubMed: 27528677
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Ziad A. Memish<affiliation><nlm:affiliation>College of Medicine, Alfaisal University, 11533 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation>
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<affiliation><nlm:affiliation>Ministry of Health, 11176 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation>
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<affiliation><nlm:affiliation>Ministry of Health, 11176 Riyadh, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
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<author><name sortKey="Gluecks, Ilona" sort="Gluecks, Ilona" uniqKey="Gluecks I" first="Ilona" last="Gluecks">Ilona Gluecks</name>
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<author><name sortKey="Bornstein, Set" sort="Bornstein, Set" uniqKey="Bornstein S" first="Set" last="Bornstein">Set Bornstein</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Wernery, Ulrich" sort="Wernery, Ulrich" uniqKey="Wernery U" first="Ulrich" last="Wernery">Ulrich Wernery</name>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty Bern, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, Bern and Mittelhausern</wicri:regionArea>
</affiliation>
</author>
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<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
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<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
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<term>Base Sequence</term>
<term>Caco-2 Cells</term>
<term>Camelus (virology)</term>
<term>Cell Line</term>
<term>Cell Line, Tumor</term>
<term>Cells, Cultured</term>
<term>Chlorocebus aethiops</term>
<term>Coronavirus (classification)</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Endemic Diseases</term>
<term>Humans</term>
<term>Kenya (epidemiology)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Phylogeny</term>
<term>Saudi Arabia (epidemiology)</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Vero Cells</term>
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<term>Arabie saoudite (épidémiologie)</term>
<term>Cellules Caco-2</term>
<term>Cellules Vero</term>
<term>Cellules cultivées</term>
<term>Chameaux (virologie)</term>
<term>Coronavirus ()</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (physiologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Humains</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Kenya (épidémiologie)</term>
<term>Lignée cellulaire</term>
<term>Lignée cellulaire tumorale</term>
<term>Maladies endémiques</term>
<term>Phylogénie</term>
<term>Similitude de séquences d'acides nucléiques</term>
<term>Séquence nucléotidique</term>
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<term>Middle East Respiratory Syndrome Coronavirus</term>
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<term>Infections à coronavirus</term>
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<term>Coronavirus Infections</term>
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<front><div type="abstract" xml:lang="en">The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.</div>
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<DateCompleted><Year>2018</Year>
<Month>03</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>113</Volume>
<Issue>35</Issue>
<PubDate><Year>2016</Year>
<Month>08</Month>
<Day>30</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation>
</Journal>
<ArticleTitle>Link of a ubiquitous human coronavirus to dromedary camels.</ArticleTitle>
<Pagination><MedlinePgn>9864-9</MedlinePgn>
</Pagination>
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<Abstract><AbstractText>The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses' evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV-infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.</AbstractText>
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<ForeName>Victor M</ForeName>
<Initials>VM</Initials>
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<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany;</Affiliation>
</AffiliationInfo>
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<ForeName>Isabella</ForeName>
<Initials>I</Initials>
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<ForeName>Ziad A</ForeName>
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<AffiliationInfo><Affiliation>College of Medicine, Alfaisal University, 11533 Riyadh, Kingdom of Saudi Arabia;</Affiliation>
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<Initials>R</Initials>
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<ForeName>Abdullah</ForeName>
<Initials>A</Initials>
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<ForeName>Ilona</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Vétérinaires Sans Frontières Suisse, Nairobi, Kenya;</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Bakri E</ForeName>
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<AffiliationInfo><Affiliation>Ministry of Science and Communication, Khartoum, Sudan;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meyer</LastName>
<ForeName>Benjamin</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Müller</LastName>
<ForeName>Marcel A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hilali</LastName>
<ForeName>Mosaad</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Cairo University, 12613 Giza, Egypt;</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Bornstein</LastName>
<ForeName>Set</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>National Veterinary Institute, 75189 Uppsala, Sweden;</Affiliation>
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<ForeName>Ulrich</ForeName>
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</Author>
<Author ValidYN="Y"><LastName>Thiel</LastName>
<ForeName>Volker</ForeName>
<Initials>V</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Jores</LastName>
<ForeName>Joerg</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>International Livestock Research Institute, Nairobi, Kenya; Institute of Veterinary Bacteriology, University of Bern, 3001 Bern, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drexler</LastName>
<ForeName>Jan Felix</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drosten</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of Bonn Medical Centre, 53127 Bonn, Germany; German Centre for Infection Research, partner site Bonn-Cologne, Germany; drexler@virology-bonn.de drosten@virology-bonn.de.</Affiliation>
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<ReferenceList><Reference><Citation>J Gen Virol. 2001 Jun;82(Pt 6):1273-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11369870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Oct;75(20):9741-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11559807</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Feb;77(4):2530-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12551991</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anim Genet. 2003 Feb;34(1):26-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12580783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Apr;77(7):4435-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12634402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2003 Aug 12;19(12):1572-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12912839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 Dec 18;349(25):2431-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Mar 12;303(5664):1666-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14752165</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Feb;79(3):1595-604</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15650185</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Feb;79(4):2001-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15681402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2006 May;87(Pt 5):1203-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16603522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Jul;80(14):7270-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16809333</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Sep;80(17):8639-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16912312</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2009 Sep;15(9):1377-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19788804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vet Diagn Invest. 2010 Jan;22(1):94-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20093692</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2012 Aug;29(8):1969-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22367748</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2012;8(8):e1002859</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22876187</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012 Sep 27;17(39):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23041020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2012;8(10):e1002950</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23055928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2012 Dec 06;17(49):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23231891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2012 Dec 12;4(12):3689-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23235471</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2013 Feb 21;18(8):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23449231</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2013 Mar;19(3):456-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23622767</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2013 Oct;19(10):1697-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24050621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Nov 28;503(7477):535-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24172901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2014 Jan;101:45-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24184128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Feb;20(2):276-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24457147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2014 Feb 25;5(2):e00884-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24570370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Apr;20(4):552-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24655412</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Jun;20(6):1049-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24856660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Jul;20(7):1231-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24964193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Aug;20(8):1319-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25075637</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Aug;20(8):1339-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25075761</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Dec;20(12):1999-2005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25418529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2014 Dec;20(12):2093-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25425139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2015 Sep;53(9):2951-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26157150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Ecol Epidemiol. 2015 Jul 15;5:28305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26183160</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2015 Dec;89(23):11858-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26378164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2015;20(49):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26676406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2016 Jan 1;351(6268):81-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26678874</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2016 Jan 1;351(6268):77-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26678878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Evol. 2015 May 26;1(1):vev003</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27774277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Jpn J Microbiol. 1971 May;15(3):276-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5000570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1996 Oct;77 ( Pt 10):2515-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8887485</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1997 Nov;78 ( Pt 11):2795-802</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9367365</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
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