MersV1, PubMed, Curation, bibRecord, 000F75

Duration of first-line antiretroviral therapy in HIV-infected treatment-naive patients in routine practice.

Identifieur interne : 000F75 ( PubMed/Curation ); précédent : 000F74; suivant : 000F76

Duration of first-line antiretroviral therapy in HIV-infected treatment-naive patients in routine practice.

Auteurs : Thomas Tesson [France] ; Mathieu Blot [France] ; Aurélie Fillion [France] ; Hama Djerad [France] ; Joséphine Cagnon-Chapalain [France] ; Aline Creuwels [France] ; Anne Waldner [France] ; Michel Duong [France] ; Marielle Buisson [France] ; Sophie Mahy [France] ; Pascal Chavanet [France] ; Lionel Piroth [France]

Source :

Antiviral therapy [ 2040-2058 ] ; 2016.

RBID : pubmed:27599563

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Association de médicaments, Facteurs temps, Femelle, Humains, Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active.
MESH :
- effets indésirables : Agents antiVIH.
- immunologie : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- virologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Association de médicaments, Facteurs temps, Femelle, Humains, Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active.

English descriptors

KwdEn :
- Adult, Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Drug Therapy, Combination, Female, HIV Infections (drug therapy), HIV Infections (immunology), HIV Infections (virology), Humans, Male, Middle Aged, Time Factors.
MESH :
- chemical , adverse effects : Anti-HIV Agents.
- chemical , therapeutic use : Anti-HIV Agents.
- drug therapy : HIV Infections.
- immunology : HIV Infections.
- virology : HIV Infections.
- Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Time Factors.

Abstract

First-line antiretroviral therapy (1st ART) is an important step in a patient's management and often considered a long-term therapy at treatment initiation.

DOI: 10.3851/IMP3084
PubMed: 27599563

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Le document en format XML

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<series><title level="j">Antiviral therapy</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anti-HIV Agents (adverse effects)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>Antiretroviral Therapy, Highly Active</term>
<term>CD4 Lymphocyte Count</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (virology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Agents antiVIH (effets indésirables)</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (virologie)</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Thérapie antirétrovirale hautement active</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Antiretroviral Therapy, Highly Active</term>
<term>CD4 Lymphocyte Count</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Association de médicaments</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Thérapie antirétrovirale hautement active</term>
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<front><div type="abstract" xml:lang="en">First-line antiretroviral therapy (1st ART) is an important step in a patient's management and often considered a long-term therapy at treatment initiation.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27599563</PMID>
<DateCompleted><Year>2018</Year>
<Month>02</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>05</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>21</Volume>
<Issue>8</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>Antiviral therapy</Title>
<ISOAbbreviation>Antivir. Ther. (Lond.)</ISOAbbreviation>
</Journal>
<ArticleTitle>Duration of first-line antiretroviral therapy in HIV-infected treatment-naive patients in routine practice.</ArticleTitle>
<Pagination><MedlinePgn>715-724</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3851/IMP3084</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">First-line antiretroviral therapy (1st ART) is an important step in a patient's management and often considered a long-term therapy at treatment initiation.</AbstractText>
<AbstractText Label="METHODS">To describe the duration of 1st ART and the factors associated with treatment modification in a recent real-life setting, antiretroviral-naive patients who began their 1st ART in six French hospitals in 2009-2012 were included in a cohort. Clinical, immunological, virological and therapeutic data, as well as the reasons for therapeutic changes, if any, were retrospectively collected.</AbstractText>
<AbstractText Label="RESULTS">A total of 206 patients started 1st ART, mainly a protease inhibitor-based triple therapy (73%), with a tenofovir-including backbone (87%). Of these, 89 (43%) had their 1st ART modified after a median of 16.5 months (IQR 8.0-32.8). Having a CD4<sup>+</sup>
 T-cell count <200 cells/mm<sup>3</sup>
, being pregnant, or 1st ART including zidovudine + lamivudine or lopinavir/r were significantly associated with a higher risk for treatment modification in multivariate analysis. In 47 patients (53%), 1st ART was modified for safety reasons, with no significant association with a given antiretroviral drug or class. No significant difference in virological, immunological and clinical outcomes was observed between the patients who had their 1st ART modified and those who did not.</AbstractText>
<AbstractText Label="CONCLUSIONS">The proportion of modifications of the 1st ART during the first 2 years remains high. These modifications are frequently because of safety issues and the willingness to simplify treatment, and less often driven by virological failure, thus emphasizing that 1st ART is not - or is no longer - a lifelong treatment.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tesson</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blot</LastName>
<ForeName>Mathieu</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fillion</LastName>
<ForeName>Aurélie</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Service des Maladies Infectieuses, CH de Chalon sur Saône, Chalon sur Saône, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Djerad</LastName>
<ForeName>Hama</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Interne, CH de Nevers, Nevers, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cagnon-Chapalain</LastName>
<ForeName>Joséphine</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Service des Maladies Infectieuses, CH de Macon, Macon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Creuwels</LastName>
<ForeName>Aline</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Interne, CH de Sens, Sens, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waldner</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duong</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buisson</LastName>
<ForeName>Marielle</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mahy</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chavanet</LastName>
<ForeName>Pascal</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>MERS UMR1347, University of Burgundy, Dijon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piroth</LastName>
<ForeName>Lionel</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Département d'infectiologie, CHU de Dijon, Dijon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>MERS UMR1347, University of Burgundy, Dijon, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Corresponding author e-mail: lionel.piroth@chu-dijon.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>09</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Antivir Ther</MedlineTA>
<NlmUniqueID>9815705</NlmUniqueID>
<ISSNLinking>1359-6535</ISSNLinking>
</MedlineJournalInfo>
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<MeshHeading><DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>08</Month>
<Day>21</Day>
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<Month>9</Month>
<Day>8</Day>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
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<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27599563</ArticleId>
<ArticleId IdType="doi">10.3851/IMP3084</ArticleId>
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   |clé=     pubmed:27599563
   |texte=   Duration of first-line antiretroviral therapy in HIV-infected treatment-naive patients in routine practice.
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Duration of first-line antiretroviral therapy in HIV-infected treatment-naive patients in routine practice.

Duration of first-line antiretroviral therapy in HIV-infected treatment-naive patients in routine practice.

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