MersV1, PubMed, Curation, bibRecord, 000A47

Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy.

Identifieur interne : 000A47 ( PubMed/Curation ); précédent : 000A46; suivant : 000A48

Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy.

Auteurs : Ana Moreno [Italie] ; Davide Lelli [Italie] ; Luca De Sabato [Italie] ; Guendalina Zaccaria [Italie] ; Arianna Boni [Italie] ; Enrica Sozzi [Italie] ; Alice Prosperi [Italie] ; Antonio Lavazza [Italie] ; Eleonora Cella [Italie] ; Maria Rita Castrucci [Italie] ; Massimo Ciccozzi [Italie] ; Gabriele Vaccari [Italie]

Source :

Virology journal [ 1743-422X ] ; 2017.

RBID : pubmed:29258555

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Base Sequence, Chiroptera (virology), Genome, Viral (genetics), Italy, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Phylogeny, Polymerase Chain Reaction, Protein Interaction Domains and Motifs, Protein Structure, Tertiary (genetics), RNA, Viral (genetics), Sequence Analysis, RNA, Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (genetics).
MESH :
- chemical , chemistry : Spike Glycoprotein, Coronavirus.
- chemical , genetics : RNA, Viral, Spike Glycoprotein, Coronavirus.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- genetics : Genome, Viral, Middle East Respiratory Syndrome Coronavirus, Protein Structure, Tertiary.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Chiroptera.
- Amino Acid Sequence, Animals, Base Sequence, Italy, Phylogeny, Polymerase Chain Reaction, Protein Interaction Domains and Motifs, Sequence Analysis, RNA.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogenetic studies suggest a bat origin. In this study, we describe the detection and full genome characterization of two CoVs closely related to MERS-CoV from two Italian bats, Pipistrellus kuhlii and Hypsugo savii.

DOI: 10.1186/s12985-017-0907-1
PubMed: 29258555

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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogenetic studies suggest a bat origin. In this study, we describe the detection and full genome characterization of two CoVs closely related to MERS-CoV from two Italian bats, Pipistrellus kuhlii and Hypsugo savii.</div>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29258555</PMID>
<DateCompleted><Year>2018</Year>
<Month>07</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1743-422X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>12</Month>
<Day>19</Day>
</PubDate>
</JournalIssue>
<Title>Virology journal</Title>
<ISOAbbreviation>Virol. J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy.</ArticleTitle>
<Pagination><MedlinePgn>239</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12985-017-0907-1</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogenetic studies suggest a bat origin. In this study, we describe the detection and full genome characterization of two CoVs closely related to MERS-CoV from two Italian bats, Pipistrellus kuhlii and Hypsugo savii.</AbstractText>
<AbstractText Label="METHODS">Pool of viscera were tested by a pan-coronavirus RT-PCR. Virus isolation was attempted by inoculation in different cell lines. Full genome sequencing was performed using the Ion Torrent platform and phylogenetic trees were performed using IQtree software. Similarity plots of CoV clade c genomes were generated by using SSE v1.2. The three dimensional macromolecular structure (3DMMS) of the receptor binding domain (RBD) in the S protein was predicted by sequence-homology method using the protein data bank (PDB).</AbstractText>
<AbstractText Label="RESULTS">Both samples resulted positive to the pan-coronavirus RT-PCR (IT-batCoVs) and their genome organization showed identical pattern of MERS CoV. Phylogenetic analysis showed a monophyletic group placed in the Beta2c clade formed by MERS-CoV sequences originating from humans and camels and bat-related sequences from Africa, Italy and China. The comparison of the secondary and 3DMMS of the RBD of IT-batCoVs with MERS, HKU4 and HKU5 bat sequences showed two aa deletions located in a region corresponding to the external subdomain of MERS-RBD in IT-batCoV and HKU5 RBDs.</AbstractText>
<AbstractText Label="CONCLUSIONS">This study reported two beta CoVs closely related to MERS that were obtained from two bats belonging to two commonly recorded species in Italy (P. kuhlii and H. savii). The analysis of the RBD showed similar structure in IT-batCoVs and HKU5 respect to HKU4 sequences. Since the RBD domain of HKU4 but not HKU5 can bind to the human DPP4 receptor for MERS-CoV, it is possible to suggest also for IT-batCoVs the absence of DPP4-binding potential. More surveillance studies are needed to better investigate the potential intermediate hosts that may play a role in the interspecies transmission of known and currently unknown coronaviruses with particular attention to the S protein and the receptor specificity and binding affinity.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moreno</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0002-8497-9708</Identifier>
<AffiliationInfo><Affiliation>Department of Virology, Istituto Zooprofilattico Sperimentale Lombardia ed Emilia Romagna, Via Antonio Bianchi 9, 25124, Brescia, Italy. anamaria.morenomartin@izsler.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lelli</LastName>
<ForeName>Davide</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Virology, Istituto Zooprofilattico Sperimentale Lombardia ed Emilia Romagna, Via Antonio Bianchi 9, 25124, Brescia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Sabato</LastName>
<ForeName>Luca</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Food Safety, Istituto Superiore di Sanità. Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dept. of Sciences, University Roma Tre, Viale Guglielmo Marconi 446, 00146, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zaccaria</LastName>
<ForeName>Guendalina</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Food Safety, Istituto Superiore di Sanità. Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boni</LastName>
<ForeName>Arianna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Food Safety, Istituto Superiore di Sanità. Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sozzi</LastName>
<ForeName>Enrica</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Virology, Istituto Zooprofilattico Sperimentale Lombardia ed Emilia Romagna, Via Antonio Bianchi 9, 25124, Brescia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prosperi</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Virology, Istituto Zooprofilattico Sperimentale Lombardia ed Emilia Romagna, Via Antonio Bianchi 9, 25124, Brescia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lavazza</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Virology, Istituto Zooprofilattico Sperimentale Lombardia ed Emilia Romagna, Via Antonio Bianchi 9, 25124, Brescia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cella</LastName>
<ForeName>Eleonora</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>University Campus Bio-Medico of Rome, Via Álvaro del Portillo, 21, 00128, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Castrucci</LastName>
<ForeName>Maria Rita</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Department of Food Safety, Istituto Superiore di Sanità. Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ciccozzi</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>University Campus Bio-Medico of Rome, Via Álvaro del Portillo, 21, 00128, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vaccari</LastName>
<ForeName>Gabriele</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Food Safety, Istituto Superiore di Sanità. Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>12</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Virol J</MedlineTA>
<NlmUniqueID>101231645</NlmUniqueID>
<ISSNLinking>1743-422X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Virol J. 2018 Jan 12;15(1):10</RefSource>
<PMID Version="1">29329554</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002685" MajorTopicYN="N">Chiroptera</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016679" MajorTopicYN="N">Genome, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N">Italy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="Y">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054730" MajorTopicYN="N">Protein Interaction Domains and Motifs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017423" MajorTopicYN="N">Sequence Analysis, RNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Bats</Keyword>
<Keyword MajorTopicYN="Y">Full genome sequencing</Keyword>
<Keyword MajorTopicYN="Y">Italy</Keyword>
<Keyword MajorTopicYN="Y">MERS-like Beta-CoV viruses</Keyword>
<Keyword MajorTopicYN="Y">Phylogenetic and molecular analyses</Keyword>
</KeywordList>
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<Month>10</Month>
<Day>20</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>12</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>12</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>12</Month>
<Day>21</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>7</Month>
<Day>18</Day>
<Hour>6</Hour>
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Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy.

Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy.

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