Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.
Identifieur interne : 000A18 ( PubMed/Curation ); précédent : 000A17; suivant : 000A19Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.
Auteurs : Susanna K P. Lau [République populaire de Chine] ; Libiao Zhang [République populaire de Chine] ; Hayes K H. Luk [République populaire de Chine] ; Lifeng Xiong [République populaire de Chine] ; Xingwen Peng [République populaire de Chine] ; Kenneth S M. Li [République populaire de Chine] ; Xiangyang He [République populaire de Chine] ; Pyrear Su-Hui Zhao [République populaire de Chine] ; Rachel Y Y. Fan [République populaire de Chine] ; Antonio C P. Wong [République populaire de Chine] ; Syed Shakeel Ahmed [République populaire de Chine] ; Jian-Piao Cai [République populaire de Chine] ; Jasper F W. Chan [République populaire de Chine] ; Yinyan Sun [République populaire de Chine] ; Dongyan Jin [République populaire de Chine] ; Honglin Chen [République populaire de Chine] ; Terrence C K. Lau [République populaire de Chine] ; Raven K H. Kok [République populaire de Chine] ; Wenhui Li [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine] ; Patrick C Y. Woo [République populaire de Chine]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2018.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ADN, Animaux, Cellules HEK293, Chiroptera, Dipeptidyl peptidase 4 (métabolisme), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Liaison aux protéines, Phylogénie, Pénétration virale, Récepteurs viraux (métabolisme), Évolution moléculaire.
- MESH :
- génétique : Glycoprotéine de spicule des coronavirus.
- métabolisme : Dipeptidyl peptidase 4, Glycoprotéine de spicule des coronavirus, Récepteurs viraux.
- Analyse de séquence d'ADN, Animaux, Cellules HEK293, Chiroptera, Humains, Liaison aux protéines, Phylogénie, Pénétration virale, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Betacoronavirus (classification), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Betacoronavirus (physiology), Chiroptera, Dipeptidyl Peptidase 4 (metabolism), Evolution, Molecular, HEK293 Cells, Humans, Phylogeny, Protein Binding, Receptors, Virus (metabolism), Sequence Analysis, DNA, Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (metabolism), Virus Internalization.
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- classification : Betacoronavirus.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- physiology : Betacoronavirus.
- Animals, Chiroptera, Evolution, Molecular, HEK293 Cells, Humans, Phylogeny, Protein Binding, Sequence Analysis, DNA, Virus Internalization.
Abstract
Although bats are known to harbor Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. We identified a novel MERS-CoV-related betacoronavirus, Hp-BatCoV HKU25, from Chinese pipistrelle bats. Although it is closely related to MERS-CoV in most genome regions, its spike protein occupies a phylogenetic position between that of Ty-BatCoV HKU4 and Pi-BatCoV HKU5. Because Ty-BatCoV HKU4 but not Pi-BatCoV HKU5 can use the MERS-CoV receptor human dipeptidyl peptidase 4 (hDPP4) for cell entry, we tested the ability of Hp-BatCoV HKU25 to bind and use hDPP4. The HKU25-receptor binding domain (RBD) can bind to hDPP4 protein and hDPP4-expressing cells, but it does so with lower efficiency than that of MERS-RBD. Pseudovirus assays showed that HKU25-spike can use hDPP4 for entry to hDPP4-expressing cells, although with lower efficiency than that of MERS-spike and HKU4-spike. Our findings support a bat origin of MERS-CoV and suggest that bat CoV spike proteins may have evolved in a stepwise manner for binding to hDPP4.
DOI: 10.1093/infdis/jiy018
PubMed: 29346682
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A18
Links to Exploration step
pubmed:29346682Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.</title><author><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K P" last="Lau">Susanna K P. Lau</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Libiao" sort="Zhang, Libiao" uniqKey="Zhang L" first="Libiao" last="Zhang">Libiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Luk, Hayes K H" sort="Luk, Hayes K H" uniqKey="Luk H" first="Hayes K H" last="Luk">Hayes K H. Luk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Xiong, Lifeng" sort="Xiong, Lifeng" uniqKey="Xiong L" first="Lifeng" last="Xiong">Lifeng Xiong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Xingwen" sort="Peng, Xingwen" uniqKey="Peng X" first="Xingwen" last="Peng">Xingwen Peng</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S M" last="Li">Kenneth S M. Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="He, Xiangyang" sort="He, Xiangyang" uniqKey="He X" first="Xiangyang" last="He">Xiangyang He</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Pyrear Su Hui" sort="Zhao, Pyrear Su Hui" uniqKey="Zhao P" first="Pyrear Su-Hui" last="Zhao">Pyrear Su-Hui Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Rachel Y Y" sort="Fan, Rachel Y Y" uniqKey="Fan R" first="Rachel Y Y" last="Fan">Rachel Y Y. Fan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Antonio C P" sort="Wong, Antonio C P" uniqKey="Wong A" first="Antonio C P" last="Wong">Antonio C P. Wong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Ahmed, Syed Shakeel" sort="Ahmed, Syed Shakeel" uniqKey="Ahmed S" first="Syed Shakeel" last="Ahmed">Syed Shakeel Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Yinyan" sort="Sun, Yinyan" uniqKey="Sun Y" first="Yinyan" last="Sun">Yinyan Sun</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Dongyan" sort="Jin, Dongyan" uniqKey="Jin D" first="Dongyan" last="Jin">Dongyan Jin</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Biomedical Sciences, The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Terrence C K" sort="Lau, Terrence C K" uniqKey="Lau T" first="Terrence C K" last="Lau">Terrence C K. Lau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, City University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Sciences, City University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29346682</idno><idno type="pmid">29346682</idno><idno type="doi">10.1093/infdis/jiy018</idno><idno type="wicri:Area/PubMed/Corpus">000A18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A18</idno><idno type="wicri:Area/PubMed/Curation">000A18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.</title><author><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K P" last="Lau">Susanna K P. Lau</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Libiao" sort="Zhang, Libiao" uniqKey="Zhang L" first="Libiao" last="Zhang">Libiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Luk, Hayes K H" sort="Luk, Hayes K H" uniqKey="Luk H" first="Hayes K H" last="Luk">Hayes K H. Luk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Xiong, Lifeng" sort="Xiong, Lifeng" uniqKey="Xiong L" first="Lifeng" last="Xiong">Lifeng Xiong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Xingwen" sort="Peng, Xingwen" uniqKey="Peng X" first="Xingwen" last="Peng">Xingwen Peng</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Li, Kenneth S M" sort="Li, Kenneth S M" uniqKey="Li K" first="Kenneth S M" last="Li">Kenneth S M. Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="He, Xiangyang" sort="He, Xiangyang" uniqKey="He X" first="Xiangyang" last="He">Xiangyang He</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Pyrear Su Hui" sort="Zhao, Pyrear Su Hui" uniqKey="Zhao P" first="Pyrear Su-Hui" last="Zhao">Pyrear Su-Hui Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Rachel Y Y" sort="Fan, Rachel Y Y" uniqKey="Fan R" first="Rachel Y Y" last="Fan">Rachel Y Y. Fan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Antonio C P" sort="Wong, Antonio C P" uniqKey="Wong A" first="Antonio C P" last="Wong">Antonio C P. Wong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Ahmed, Syed Shakeel" sort="Ahmed, Syed Shakeel" uniqKey="Ahmed S" first="Syed Shakeel" last="Ahmed">Syed Shakeel Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F W" last="Chan">Jasper F W. Chan</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Yinyan" sort="Sun, Yinyan" uniqKey="Sun Y" first="Yinyan" last="Sun">Yinyan Sun</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Dongyan" sort="Jin, Dongyan" uniqKey="Jin D" first="Dongyan" last="Jin">Dongyan Jin</name><affiliation wicri:level="1"><nlm:affiliation>School of Biomedical Sciences, The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Biomedical Sciences, The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Lau, Terrence C K" sort="Lau, Terrence C K" uniqKey="Lau T" first="Terrence C K" last="Lau">Terrence C K. Lau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, City University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biomedical Sciences, City University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Kok, Raven K H" sort="Kok, Raven K H" uniqKey="Kok R" first="Raven K H" last="Kok">Raven K H. Kok</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Li, Wenhui" sort="Li, Wenhui" uniqKey="Li W" first="Wenhui" last="Li">Wenhui Li</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Betacoronavirus (classification)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Betacoronavirus (physiology)</term><term>Chiroptera</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Evolution, Molecular</term><term>HEK293 Cells</term><term>Humans</term><term>Phylogeny</term><term>Protein Binding</term><term>Receptors, Virus (metabolism)</term><term>Sequence Analysis, DNA</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Cellules HEK293</term><term>Chiroptera</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Phylogénie</term><term>Pénétration virale</term><term>Récepteurs viraux (métabolisme)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term><term>Glycoprotéine de spicule des coronavirus</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chiroptera</term><term>Evolution, Molecular</term><term>HEK293 Cells</term><term>Humans</term><term>Phylogeny</term><term>Protein Binding</term><term>Sequence Analysis, DNA</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Cellules HEK293</term><term>Chiroptera</term><term>Humains</term><term>Liaison aux protéines</term><term>Phylogénie</term><term>Pénétration virale</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although bats are known to harbor Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. We identified a novel MERS-CoV-related betacoronavirus, Hp-BatCoV HKU25, from Chinese pipistrelle bats. Although it is closely related to MERS-CoV in most genome regions, its spike protein occupies a phylogenetic position between that of Ty-BatCoV HKU4 and Pi-BatCoV HKU5. Because Ty-BatCoV HKU4 but not Pi-BatCoV HKU5 can use the MERS-CoV receptor human dipeptidyl peptidase 4 (hDPP4) for cell entry, we tested the ability of Hp-BatCoV HKU25 to bind and use hDPP4. The HKU25-receptor binding domain (RBD) can bind to hDPP4 protein and hDPP4-expressing cells, but it does so with lower efficiency than that of MERS-RBD. Pseudovirus assays showed that HKU25-spike can use hDPP4 for entry to hDPP4-expressing cells, although with lower efficiency than that of MERS-spike and HKU4-spike. Our findings support a bat origin of MERS-CoV and suggest that bat CoV spike proteins may have evolved in a stepwise manner for binding to hDPP4.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29346682</PMID><DateCompleted><Year>2019</Year><Month>09</Month><Day>12</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>218</Volume><Issue>2</Issue><PubDate><Year>2018</Year><Month>06</Month><Day>20</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.</ArticleTitle><Pagination><MedlinePgn>197-207</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiy018</ELocationID><Abstract><AbstractText>Although bats are known to harbor Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. We identified a novel MERS-CoV-related betacoronavirus, Hp-BatCoV HKU25, from Chinese pipistrelle bats. Although it is closely related to MERS-CoV in most genome regions, its spike protein occupies a phylogenetic position between that of Ty-BatCoV HKU4 and Pi-BatCoV HKU5. Because Ty-BatCoV HKU4 but not Pi-BatCoV HKU5 can use the MERS-CoV receptor human dipeptidyl peptidase 4 (hDPP4) for cell entry, we tested the ability of Hp-BatCoV HKU25 to bind and use hDPP4. The HKU25-receptor binding domain (RBD) can bind to hDPP4 protein and hDPP4-expressing cells, but it does so with lower efficiency than that of MERS-RBD. Pseudovirus assays showed that HKU25-spike can use hDPP4 for entry to hDPP4-expressing cells, although with lower efficiency than that of MERS-spike and HKU4-spike. Our findings support a bat origin of MERS-CoV and suggest that bat CoV spike proteins may have evolved in a stepwise manner for binding to hDPP4.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Susanna K P</ForeName><Initials>SKP</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carol Yu Centre for Infection The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Libiao</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luk</LastName><ForeName>Hayes K H</ForeName><Initials>HKH</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Lifeng</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Xingwen</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Kenneth S M</ForeName><Initials>KSM</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Xiangyang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, and Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Pyrear Su-Hui</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Rachel Y Y</ForeName><Initials>RYY</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Antonio C P</ForeName><Initials>ACP</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Syed Shakeel</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Jian-Piao</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Jasper F W</ForeName><Initials>JFW</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carol Yu Centre for Infection The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yinyan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Dongyan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Honglin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carol Yu Centre for Infection The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Terrence C K</ForeName><Initials>TCK</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, City University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kok</LastName><ForeName>Raven K H</ForeName><Initials>RKH</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carol Yu Centre for Infection The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Wenhui</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>National Institute of Biological Sciences, Zhongguancun Life Science Park, Changping, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carol Yu Centre for Infection The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woo</LastName><ForeName>Patrick C Y</ForeName><Initials>PCY</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carol Yu Centre for Infection The University of Hong Kong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011991">Receptors, Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber><NameOfSubstance UI="C042807">DPP4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.14.5</RegistryNumber><NameOfSubstance UI="D018819">Dipeptidyl Peptidase 4</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002685" MajorTopicYN="Y">Chiroptera</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018819" MajorTopicYN="N">Dipeptidyl Peptidase 4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053586" MajorTopicYN="Y">Virus Internalization</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>11</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>01</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29346682</ArticleId><ArticleId IdType="pii">4810771</ArticleId><ArticleId IdType="doi">10.1093/infdis/jiy018</ArticleId><ArticleId IdType="pmc">PMC7107427</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>mBio. 2014 Feb 18;5(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">24549846</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS Curr. 2011 Feb 04;3:RRN1212</Citation><ArticleIdList><ArticleId IdType="pubmed">21327164</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Curr Top Microbiol Immunol. 2005;287:1-30</Citation><ArticleIdList><ArticleId IdType="pubmed">15609507</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2014 Oct;88(19):11297-303</Citation><ArticleIdList><ArticleId IdType="pubmed">25031349</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12516-21</Citation><ArticleIdList><ArticleId IdType="pubmed">25114257</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 2016 Jan 1;351(6268):81-4</Citation><ArticleIdList><ArticleId IdType="pubmed">26678874</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2001 May-Jun;7(3):439-41</Citation><ArticleIdList><ArticleId IdType="pubmed">11384522</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Res. 2013 Aug;23(8):986-93</Citation><ArticleIdList><ArticleId IdType="pubmed">23835475</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16169905</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Sci Rep. 2016 Feb 22;6:21878</Citation><ArticleIdList><ArticleId IdType="pubmed">26899616</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2430-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15695582</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2015 Oct;89(20):10532-47</Citation><ArticleIdList><ArticleId IdType="pubmed">26269185</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2013 Sep;13(9):745-51</Citation><ArticleIdList><ArticleId IdType="pubmed">23782859</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2013 Oct;13(10):859-66</Citation><ArticleIdList><ArticleId IdType="pubmed">23933067</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Adv Virus Res. 1997;48:1-100</Citation><ArticleIdList><ArticleId IdType="pubmed">9233431</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Clin Microbiol Rev. 2015 Apr;28(2):465-522</Citation><ArticleIdList><ArticleId IdType="pubmed">25810418</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation><ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Environ Microbiol. 2017 Mar;19(3):1266-1280</Citation><ArticleIdList><ArticleId IdType="pubmed">28028888</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2015 Jul;89(14):7202-13</Citation><ArticleIdList><ArticleId IdType="pubmed">25926653</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2012 Apr;86(7):3995-4008</Citation><ArticleIdList><ArticleId IdType="pubmed">22278237</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Feb;14(2):140-5</Citation><ArticleIdList><ArticleId IdType="pubmed">24355866</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Infect Dis. 2014 Jan;14(1):50-56</Citation><ArticleIdList><ArticleId IdType="pubmed">24239323</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nature. 2013 Aug 8;500(7461):227-31</Citation><ArticleIdList><ArticleId IdType="pubmed">23831647</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2013 Nov;87(22):12489-95</Citation><ArticleIdList><ArticleId IdType="pubmed">24027320</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Host Microbe. 2014 Sep 10;16(3):328-37</Citation><ArticleIdList><ArticleId IdType="pubmed">25211075</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 2006 Jul 20;351(1):180-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16647731</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2010 Mar;84(6):2808-19</Citation><ArticleIdList><ArticleId IdType="pubmed">20071579</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>mBio. 2016 Mar 29;7(2):e00258</Citation><ArticleIdList><ArticleId IdType="pubmed">27025250</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nature. 2013 Mar 14;495(7440):251-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23486063</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>mBio. 2017 Apr 4;8(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">28377531</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nucleic Acids Res. 2008 Jan;36(Database issue):D504-11</Citation><ArticleIdList><ArticleId IdType="pubmed">17913743</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2007 Feb;81(4):1574-85</Citation><ArticleIdList><ArticleId IdType="pubmed">17121802</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>mBio. 2012 Nov 20;3(6):</Citation><ArticleIdList><ArticleId IdType="pubmed">23170002</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2013 Aug;87(15):8638-50</Citation><ArticleIdList><ArticleId IdType="pubmed">23720729</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Med. 2004 Apr;10(4):368-73</Citation><ArticleIdList><ArticleId IdType="pubmed">15034574</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2005 Jan;79(2):884-95</Citation><ArticleIdList><ArticleId IdType="pubmed">15613317</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2012 May;86(10):5481-96</Citation><ArticleIdList><ArticleId IdType="pubmed">22398294</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2014 Jul;20(7):1260-2</Citation><ArticleIdList><ArticleId IdType="pubmed">24960574</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation><ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2008 Feb;82(4):1819-26</Citation><ArticleIdList><ArticleId IdType="pubmed">18057240</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>PLoS One. 2014 Nov 19;9(11):e112060</Citation><ArticleIdList><ArticleId IdType="pubmed">25409519</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2015 Mar;89(6):3076-92</Citation><ArticleIdList><ArticleId IdType="pubmed">25552712</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Microbes Infect. 2012 Nov;1(11):e35</Citation><ArticleIdList><ArticleId IdType="pubmed">26038405</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2014 Jan;88(1):237-48</Citation><ArticleIdList><ArticleId IdType="pubmed">24155382</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Microbes Infect. 2016 Dec 21;5(12):e128</Citation><ArticleIdList><ArticleId IdType="pubmed">27999424</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A18 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000A18 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:29346682
|texte= Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:29346682" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |