MersV1, PubMed, Curation, bibRecord, 000892

Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus.

Identifieur interne : 000892 ( PubMed/Curation ); précédent : 000891; suivant : 000893

Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus.

Auteurs : Wei-Chen Hsin [Taïwan] ; Chan-Hua Chang [Taïwan] ; Chi-You Chang [Taïwan] ; Wei-Hao Peng [Taïwan] ; Chung-Liang Chien [Taïwan] ; Ming-Fu Chang [Taïwan] ; Shin C. Chang [Taïwan]

Source :

Journal of biomedical science [ 1423-0127 ] ; 2018.

RBID : pubmed:29793506

Descripteurs français

KwdFr :
- ARN messager (métabolisme), ARN viral (métabolisme), Assemblage viral (génétique), Cellules HEK293, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Lignée cellulaire tumorale, Protéines nucléocapside (métabolisme).
MESH :
- génétique : Assemblage viral.
- métabolisme : ARN messager, ARN viral, Protéines nucléocapside.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- Cellules HEK293, Humains, Lignée cellulaire tumorale.

English descriptors

KwdEn :
- Cell Line, Tumor, HEK293 Cells, Humans, Middle East Respiratory Syndrome Coronavirus (physiology), Nucleocapsid Proteins (metabolism), RNA, Messenger (metabolism), RNA, Viral (metabolism), Virus Assembly (genetics).
MESH :
- chemical , metabolism : Nucleocapsid Proteins, RNA, Messenger, RNA, Viral.
- genetics : Virus Assembly.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- Cell Line, Tumor, HEK293 Cells, Humans.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus particles involves viral structural proteins and is believed to be mediated through recognition of specific sequences and RNA structures of the viral genome.

DOI: 10.1186/s12929-018-0449-x
PubMed: 29793506

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Le document en format XML

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<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Nucleocapsid Proteins (metabolism)</term>
<term>RNA, Messenger (metabolism)</term>
<term>RNA, Viral (metabolism)</term>
<term>Virus Assembly (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term>
<term>ARN viral (métabolisme)</term>
<term>Assemblage viral (génétique)</term>
<term>Cellules HEK293</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Protéines nucléocapside (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nucleocapsid Proteins</term>
<term>RNA, Messenger</term>
<term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Virus Assembly</term>
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</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>ARN viral</term>
<term>Protéines nucléocapside</term>
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<term>HEK293 Cells</term>
<term>Humans</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus particles involves viral structural proteins and is believed to be mediated through recognition of specific sequences and RNA structures of the viral genome.</div>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29793506</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1423-0127</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>25</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>May</Month>
<Day>24</Day>
</PubDate>
</JournalIssue>
<Title>Journal of biomedical science</Title>
<ISOAbbreviation>J. Biomed. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus.</ArticleTitle>
<Pagination><MedlinePgn>47</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12929-018-0449-x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus particles involves viral structural proteins and is believed to be mediated through recognition of specific sequences and RNA structures of the viral genome.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">A culture system for the production of MERS coronavirus-like particles (MERS VLPs) was determined and established by electron microscopy and the detection of coexpressed viral structural proteins. Using the VLP system, a 258-nucleotide RNA fragment, which spans nucleotides 19,712 to 19,969 of the MERS-CoV genome (designated PS258(19712-19969)<sub>ME</sub>
), was identified to function as a packaging signal. Assembly of the RNA packaging signal into MERS VLPs is dependent on the viral nucleocapsid protein. In addition, a 45-nucleotide stable stem-loop substructure of the PS258(19712-19969)<sub>ME</sub>
 interacted with both the N-terminal domain and the C-terminal domain of the viral nucleocapsid protein. Furthermore, a functional SARS-CoV RNA packaging signal failed to assemble into the MERS VLPs, which indicated virus-specific assembly of the RNA genome.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A MERS-oV RNA packaging signal was identified by the detection of GFP expression following an incubation of MERS VLPs carrying the heterologous mRNA GFP-PS258(19712-19969)<sub>ME</sub>
 with virus permissive Huh7 cells. The MERS VLP system could help us in understanding virus infection and morphogenesis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hsin</LastName>
<ForeName>Wei-Chen</ForeName>
<Initials>WC</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Chan-Hua</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Chi-You</ForeName>
<Initials>CY</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peng</LastName>
<ForeName>Wei-Hao</ForeName>
<Initials>WH</Initials>
<AffiliationInfo><Affiliation>Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chien</LastName>
<ForeName>Chung-Liang</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Ming-Fu</ForeName>
<Initials>MF</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan. mfchang@ntu.edu.tw.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Shin C</ForeName>
<Initials>SC</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-0365-8364</Identifier>
<AffiliationInfo><Affiliation>Institute of Microbiology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, First Section, Taipei, 100, Taiwan. scchang093@ntu.edu.tw.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>102-2321-B-002-028</GrantID>
<Agency>Ministry of Science and Technology, Taiwan</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>107-2321-B-002-023</GrantID>
<Agency>Ministry of Science and Technology, Taiwan</Agency>
<Country></Country>
</Grant>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>05</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Biomed Sci</MedlineTA>
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<ISSNLinking>1021-7770</ISSNLinking>
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<Month>05</Month>
<Day>15</Day>
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Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus.

Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus.

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