A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.
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Auteurs : Anwar M. Hashem ; Abdullah Algaissi ; Anurodh Shankar Agrawal ; Sawsan S. Al-Amri [Arabie saoudite] ; Rowa Y. Alhabbab [Arabie saoudite] ; Sayed S. Sohrab [Arabie saoudite] ; Abdulrahman S Almasoud [Arabie saoudite] ; Naif Khalaf Alharbi [Arabie saoudite] ; Bi-Hung Peng ; Marsha Russell [Canada] ; Xuguang Li [Canada] ; Chien-Te K. TsengSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2019.
Abstract
Infection control measures have played a major role in limiting human/camel-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); however, development of effective and safe human or camel vaccines is warranted.
DOI: 10.1093/infdis/jiz137
PubMed: 30911758
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Anwar M. Hashem<affiliation><nlm:affiliation>Department of Medical Microbiology and Parasitology, Faculty of Medicine.</nlm:affiliation><wicri:noCountry code="subField">Faculty of Medicine</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.</title><author><name sortKey="Hashem, Anwar M" sort="Hashem, Anwar M" uniqKey="Hashem A" first="Anwar M" last="Hashem">Anwar M. Hashem</name><affiliation><nlm:affiliation>Department of Medical Microbiology and Parasitology, Faculty of Medicine.</nlm:affiliation><wicri:noCountry code="subField">Faculty of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Algaissi, Abdullah" sort="Algaissi, Abdullah" uniqKey="Algaissi A" first="Abdullah" last="Algaissi">Abdullah Algaissi</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author><author><name sortKey="Agrawal, Anurodh Shankar" sort="Agrawal, Anurodh Shankar" uniqKey="Agrawal A" first="Anurodh Shankar" last="Agrawal">Anurodh Shankar Agrawal</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author><author><name sortKey="Al Amri, Sawsan S" sort="Al Amri, Sawsan S" uniqKey="Al Amri S" first="Sawsan S" last="Al-Amri">Sawsan S. Al-Amri</name><affiliation wicri:level="1"><nlm:affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center</wicri:regionArea></affiliation></author><author><name sortKey="Alhabbab, Rowa Y" sort="Alhabbab, Rowa Y" uniqKey="Alhabbab R" first="Rowa Y" last="Alhabbab">Rowa Y. Alhabbab</name><affiliation wicri:level="1"><nlm:affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center</wicri:regionArea></affiliation></author><author><name sortKey="Sohrab, Sayed S" sort="Sohrab, Sayed S" uniqKey="Sohrab S" first="Sayed S" last="Sohrab">Sayed S. Sohrab</name><affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea></affiliation></author><author><name sortKey="S Almasoud, Abdulrahman" sort="S Almasoud, Abdulrahman" uniqKey="S Almasoud A" first="Abdulrahman" last="S Almasoud">Abdulrahman S Almasoud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Bi Hung" sort="Peng, Bi Hung" uniqKey="Peng B" first="Bi-Hung" last="Peng">Bi-Hung Peng</name><affiliation><nlm:affiliation>Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author><author><name sortKey="Russell, Marsha" sort="Russell, Marsha" uniqKey="Russell M" first="Marsha" last="Russell">Marsha Russell</name><affiliation wicri:level="2"><nlm:affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Li, Xuguang" sort="Li, Xuguang" uniqKey="Li X" first="Xuguang" last="Li">Xuguang Li</name><affiliation wicri:level="2"><nlm:affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K" last="Tseng">Chien-Te K. Tseng</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30911758</idno><idno type="pmid">30911758</idno><idno type="doi">10.1093/infdis/jiz137</idno><idno type="wicri:Area/PubMed/Corpus">000596</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000596</idno><idno type="wicri:Area/PubMed/Curation">000596</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000596</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.</title><author><name sortKey="Hashem, Anwar M" sort="Hashem, Anwar M" uniqKey="Hashem A" first="Anwar M" last="Hashem">Anwar M. Hashem</name><affiliation><nlm:affiliation>Department of Medical Microbiology and Parasitology, Faculty of Medicine.</nlm:affiliation><wicri:noCountry code="subField">Faculty of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Algaissi, Abdullah" sort="Algaissi, Abdullah" uniqKey="Algaissi A" first="Abdullah" last="Algaissi">Abdullah Algaissi</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author><author><name sortKey="Agrawal, Anurodh Shankar" sort="Agrawal, Anurodh Shankar" uniqKey="Agrawal A" first="Anurodh Shankar" last="Agrawal">Anurodh Shankar Agrawal</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author><author><name sortKey="Al Amri, Sawsan S" sort="Al Amri, Sawsan S" uniqKey="Al Amri S" first="Sawsan S" last="Al-Amri">Sawsan S. Al-Amri</name><affiliation wicri:level="1"><nlm:affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center</wicri:regionArea></affiliation></author><author><name sortKey="Alhabbab, Rowa Y" sort="Alhabbab, Rowa Y" uniqKey="Alhabbab R" first="Rowa Y" last="Alhabbab">Rowa Y. Alhabbab</name><affiliation wicri:level="1"><nlm:affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center</wicri:regionArea></affiliation></author><author><name sortKey="Sohrab, Sayed S" sort="Sohrab, Sayed S" uniqKey="Sohrab S" first="Sayed S" last="Sohrab">Sayed S. Sohrab</name><affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah</wicri:regionArea></affiliation></author><author><name sortKey="S Almasoud, Abdulrahman" sort="S Almasoud, Abdulrahman" uniqKey="S Almasoud A" first="Abdulrahman" last="S Almasoud">Abdulrahman S Almasoud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Bi Hung" sort="Peng, Bi Hung" uniqKey="Peng B" first="Bi-Hung" last="Peng">Bi-Hung Peng</name><affiliation><nlm:affiliation>Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author><author><name sortKey="Russell, Marsha" sort="Russell, Marsha" uniqKey="Russell M" first="Marsha" last="Russell">Marsha Russell</name><affiliation wicri:level="2"><nlm:affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Li, Xuguang" sort="Li, Xuguang" uniqKey="Li X" first="Xuguang" last="Li">Xuguang Li</name><affiliation wicri:level="2"><nlm:affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa</wicri:cityArea></affiliation></author><author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K" last="Tseng">Chien-Te K. Tseng</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation><wicri:noCountry code="subField">Galveston</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infection control measures have played a major role in limiting human/camel-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); however, development of effective and safe human or camel vaccines is warranted.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">30911758</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>220</Volume><Issue>10</Issue><PubDate><Year>2019</Year><Month>Oct</Month><Day>08</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.</ArticleTitle><Pagination><MedlinePgn>1558-1567</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiz137</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Infection control measures have played a major role in limiting human/camel-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); however, development of effective and safe human or camel vaccines is warranted.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We extended and optimized our previous recombinant adenovirus 5 (rAd5)-based vaccine platform characterized by in vivo amplified and CD40-mediated specific responses to generate MERS-CoV S1 subunit-based vaccine. We generated rAd5 constructs expressing CD40-targeted S1 fusion protein (rAd5-S1/F/CD40L), untargeted S1 (rAd5-S1), and Green Fluorescent Protein (rAd5-GFP), and evaluated their efficacy and safety in human dipeptidyl peptidase 4 transgenic (hDPP4 Tg+) mice.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Immunization of hDPP4 Tg+ mice with a single dose of rAd5-S1/F/CD40L elicited as robust and significant specific immunoglobulin G and neutralizing antibodies as those induced with 2 doses of rAd5-S1. After MERS-CoV challenge, both vaccines conferred complete protection against morbidity and mortality, as evidenced by significantly undetectable/reduced pulmonary viral loads compared to the control group. However, rAd5-S1- but not rAd5-S1/F/CD40L-immunized mice exhibited marked pulmonary perivascular hemorrhage post-MERS-CoV challenge despite the observed protection.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Incorporation of CD40L into rAd5-based MERS-CoV S1 vaccine targeting molecule and molecular adjuvants not only enhances immunogenicity and efficacy but also prevents inadvertent pulmonary pathology after viral challenge, thereby offering a promising strategy to enhance safety and potency of vaccines.</AbstractText><CopyrightInformation>© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hashem</LastName><ForeName>Anwar M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology and Parasitology, Faculty of Medicine.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Algaissi</LastName><ForeName>Abdullah</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agrawal</LastName><ForeName>Anurodh Shankar</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Amri</LastName><ForeName>Sawsan S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alhabbab</LastName><ForeName>Rowa Y</ForeName><Initials>RY</Initials><AffiliationInfo><Affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sohrab</LastName><ForeName>Sayed S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>S Almasoud</LastName><ForeName>Abdulrahman</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alharbi</LastName><ForeName>Naif Khalaf</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Bi-Hung</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Marsha</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xuguang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tseng</LastName><ForeName>Chien-Te K</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Biodefense and Emerging Disease, University of Texas Medical Branch, Galveston.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CD40L</Keyword><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">adenovirus</Keyword><Keyword MajorTopicYN="N">immunopathology</Keyword><Keyword MajorTopicYN="N">vaccine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>01</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>03</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30911758</ArticleId><ArticleId IdType="pii">5419855</ArticleId><ArticleId 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