A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.
Identifieur interne : 000596 ( PubMed/Curation ); précédent : 000595; suivant : 000597A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.
Auteurs : Anwar M. Hashem ; Abdullah Algaissi ; Anurodh Shankar Agrawal ; Sawsan S. Al-Amri [Arabie saoudite] ; Rowa Y. Alhabbab [Arabie saoudite] ; Sayed S. Sohrab [Arabie saoudite] ; Abdulrahman S Almasoud [Arabie saoudite] ; Naif Khalaf Alharbi [Arabie saoudite] ; Bi-Hung Peng ; Marsha Russell [Canada] ; Xuguang Li [Canada] ; Chien-Te K. TsengSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2019.
Abstract
Infection control measures have played a major role in limiting human/camel-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); however, development of effective and safe human or camel vaccines is warranted.
DOI: 10.1093/infdis/jiz137
PubMed: 30911758
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Anwar M. Hashem<affiliation><nlm:affiliation>Department of Medical Microbiology and Parasitology, Faculty of Medicine.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</nlm:affiliation>
<wicri:noCountry code="subField">Galveston</wicri:noCountry>
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Le document en format XML
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<author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K" last="Tseng">Chien-Te K. Tseng</name>
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<front><div type="abstract" xml:lang="en">Infection control measures have played a major role in limiting human/camel-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); however, development of effective and safe human or camel vaccines is warranted.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">30911758</PMID>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>220</Volume>
<Issue>10</Issue>
<PubDate><Year>2019</Year>
<Month>Oct</Month>
<Day>08</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model.</ArticleTitle>
<Pagination><MedlinePgn>1558-1567</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiz137</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Infection control measures have played a major role in limiting human/camel-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); however, development of effective and safe human or camel vaccines is warranted.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We extended and optimized our previous recombinant adenovirus 5 (rAd5)-based vaccine platform characterized by in vivo amplified and CD40-mediated specific responses to generate MERS-CoV S1 subunit-based vaccine. We generated rAd5 constructs expressing CD40-targeted S1 fusion protein (rAd5-S1/F/CD40L), untargeted S1 (rAd5-S1), and Green Fluorescent Protein (rAd5-GFP), and evaluated their efficacy and safety in human dipeptidyl peptidase 4 transgenic (hDPP4 Tg+) mice.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Immunization of hDPP4 Tg+ mice with a single dose of rAd5-S1/F/CD40L elicited as robust and significant specific immunoglobulin G and neutralizing antibodies as those induced with 2 doses of rAd5-S1. After MERS-CoV challenge, both vaccines conferred complete protection against morbidity and mortality, as evidenced by significantly undetectable/reduced pulmonary viral loads compared to the control group. However, rAd5-S1- but not rAd5-S1/F/CD40L-immunized mice exhibited marked pulmonary perivascular hemorrhage post-MERS-CoV challenge despite the observed protection.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Incorporation of CD40L into rAd5-based MERS-CoV S1 vaccine targeting molecule and molecular adjuvants not only enhances immunogenicity and efficacy but also prevents inadvertent pulmonary pathology after viral challenge, thereby offering a promising strategy to enhance safety and potency of vaccines.</AbstractText>
<CopyrightInformation>© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hashem</LastName>
<ForeName>Anwar M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Medical Microbiology and Parasitology, Faculty of Medicine.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Algaissi</LastName>
<ForeName>Abdullah</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Agrawal</LastName>
<ForeName>Anurodh Shankar</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Al-Amri</LastName>
<ForeName>Sawsan S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alhabbab</LastName>
<ForeName>Rowa Y</ForeName>
<Initials>RY</Initials>
<AffiliationInfo><Affiliation>Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sohrab</LastName>
<ForeName>Sayed S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>S Almasoud</LastName>
<ForeName>Abdulrahman</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alharbi</LastName>
<ForeName>Naif Khalaf</ForeName>
<Initials>NK</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peng</LastName>
<ForeName>Bi-Hung</ForeName>
<Initials>BH</Initials>
<AffiliationInfo><Affiliation>Department of Neurosciences, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Russell</LastName>
<ForeName>Marsha</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xuguang</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Center for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Ontario.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tseng</LastName>
<ForeName>Chien-Te K</ForeName>
<Initials>CK</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center of Biodefense and Emerging Disease, University of Texas Medical Branch, Galveston.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
<ISSNLinking>0022-1899</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CD40L</Keyword>
<Keyword MajorTopicYN="N">MERS-CoV</Keyword>
<Keyword MajorTopicYN="N">adenovirus</Keyword>
<Keyword MajorTopicYN="N">immunopathology</Keyword>
<Keyword MajorTopicYN="N">vaccine</Keyword>
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<Month>01</Month>
<Day>08</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>03</Month>
<Day>21</Day>
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<Month>3</Month>
<Day>27</Day>
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