Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus.
Identifieur interne : 000450 ( PubMed/Curation ); précédent : 000449; suivant : 000451Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus.
Auteurs : Chean Yeah Yong [Malaisie] ; Hui Kian Ong [Malaisie] ; Swee Keong Yeap [Malaisie] ; Kok Lian Ho [Malaisie] ; Wen Siang Tan [Malaisie]Source :
- Frontiers in microbiology [ 1664-302X ] ; 2019.
Abstract
Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven effective against this viral disease. In addition, no vaccine has been licensed to prevent MERS-CoV infection thus far. Therefore, our current review focuses on the most recent studies in search of an effective MERS vaccine. Overall, vaccine candidates against MERS-CoV are mainly based upon the viral spike (S) protein, due to its vital role in the viral infectivity, although several studies focused on other viral proteins such as the nucleocapsid (N) protein, envelope (E) protein, and non-structural protein 16 (NSP16) have also been reported. In general, the potential vaccine candidates can be classified into six types: viral vector-based vaccine, DNA vaccine, subunit vaccine, nanoparticle-based vaccine, inactivated-whole virus vaccine and live-attenuated vaccine, which are discussed in detail. Besides, the immune responses and potential antibody dependent enhancement of MERS-CoV infection are extensively reviewed. In addition, animal models used to study MERS-CoV and evaluate the vaccine candidates are discussed intensively.
DOI: 10.3389/fmicb.2019.01781
PubMed: 31428074
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sort="Ong, Hui Kian" uniqKey="Ong H" first="Hui Kian" last="Ong">Hui Kian Ong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang</wicri:regionArea></affiliation></author><author><name sortKey="Yeap, Swee Keong" sort="Yeap, Swee Keong" uniqKey="Yeap S" first="Swee Keong" last="Yeap">Swee Keong Yeap</name><affiliation wicri:level="1"><nlm:affiliation>China ASEAN College of Marine Sciences, Xiamen University Malaysia, Sepang, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>China ASEAN College of Marine Sciences, Xiamen University Malaysia, Sepang</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Kok Lian" sort="Ho, Kok Lian" uniqKey="Ho K" first="Kok Lian" last="Ho">Kok Lian Ho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Wen Siang" sort="Tan, Wen Siang" uniqKey="Tan W" first="Wen Siang" last="Tan">Wen Siang Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in microbiology</title><idno type="ISSN">1664-302X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven effective against this viral disease. In addition, no vaccine has been licensed to prevent MERS-CoV infection thus far. Therefore, our current review focuses on the most recent studies in search of an effective MERS vaccine. Overall, vaccine candidates against MERS-CoV are mainly based upon the viral spike (S) protein, due to its vital role in the viral infectivity, although several studies focused on other viral proteins such as the nucleocapsid (N) protein, envelope (E) protein, and non-structural protein 16 (NSP16) have also been reported. In general, the potential vaccine candidates can be classified into six types: viral vector-based vaccine, DNA vaccine, subunit vaccine, nanoparticle-based vaccine, inactivated-whole virus vaccine and live-attenuated vaccine, which are discussed in detail. Besides, the immune responses and potential antibody dependent enhancement of MERS-CoV infection are extensively reviewed. In addition, animal models used to study MERS-CoV and evaluate the vaccine candidates are discussed intensively.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31428074</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-302X</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Frontiers in microbiology</Title><ISOAbbreviation>Front Microbiol</ISOAbbreviation></Journal><ArticleTitle>Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus.</ArticleTitle><Pagination><MedlinePgn>1781</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmicb.2019.01781</ELocationID><Abstract><AbstractText>Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven effective against this viral disease. In addition, no vaccine has been licensed to prevent MERS-CoV infection thus far. Therefore, our current review focuses on the most recent studies in search of an effective MERS vaccine. Overall, vaccine candidates against MERS-CoV are mainly based upon the viral spike (S) protein, due to its vital role in the viral infectivity, although several studies focused on other viral proteins such as the nucleocapsid (N) protein, envelope (E) protein, and non-structural protein 16 (NSP16) have also been reported. In general, the potential vaccine candidates can be classified into six types: viral vector-based vaccine, DNA vaccine, subunit vaccine, nanoparticle-based vaccine, inactivated-whole virus vaccine and live-attenuated vaccine, which are discussed in detail. Besides, the immune responses and potential antibody dependent enhancement of MERS-CoV infection are extensively reviewed. In addition, animal models used to study MERS-CoV and evaluate the vaccine candidates are discussed intensively.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yong</LastName><ForeName>Chean Yeah</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ong</LastName><ForeName>Hui Kian</ForeName><Initials>HK</Initials><AffiliationInfo><Affiliation>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeap</LastName><ForeName>Swee Keong</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>China ASEAN College of Marine Sciences, Xiamen University Malaysia, Sepang, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Kok Lian</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Wen Siang</ForeName><Initials>WS</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 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