Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Identifieur interne : 000266 ( PubMed/Curation ); précédent : 000265; suivant : 000267Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.
Auteurs : Li-Li Ren [République populaire de Chine] ; Ye-Ming Wang [République populaire de Chine] ; Zhi-Qiang Wu [République populaire de Chine] ; Zi-Chun Xiang [République populaire de Chine] ; Li Guo [République populaire de Chine] ; Teng Xu [République populaire de Chine] ; Yong-Zhong Jiang [République populaire de Chine] ; Yan Xiong [République populaire de Chine] ; Yong-Jun Li [République populaire de Chine] ; Xing-Wang Li [République populaire de Chine] ; Hui Li [République populaire de Chine] ; Guo-Hui Fan [République populaire de Chine] ; Xiao-Ying Gu [République populaire de Chine] ; Yan Xiao [République populaire de Chine] ; Hong Gao [République populaire de Chine] ; Jiu-Yang Xu [République populaire de Chine] ; Fan Yang [République populaire de Chine] ; Xin-Ming Wang [République populaire de Chine] ; Chao Wu [République populaire de Chine] ; Lan Chen [République populaire de Chine] ; Yi-Wei Liu [République populaire de Chine] ; Bo Liu [République populaire de Chine] ; Jian Yang [République populaire de Chine] ; Xiao-Rui Wang [République populaire de Chine] ; Jie Dong [République populaire de Chine] ; Li Li [République populaire de Chine] ; Chao-Lin Huang [République populaire de Chine] ; Jian-Ping Zhao [République populaire de Chine] ; Yi Hu [République populaire de Chine] ; Zhen-Shun Cheng [République populaire de Chine] ; Lin-Lin Liu [République populaire de Chine] ; Zhao-Hui Qian [République populaire de Chine] ; Chuan Qin [République populaire de Chine] ; Qi Jin [République populaire de Chine] ; Bin Cao [République populaire de Chine] ; Jian-Wei Wang [République populaire de Chine]Source :
- Chinese medical journal [ 2542-5641 ] ; 2020.
Abstract
Human infections with zoonotic coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, have raised great public health concern globally. Here, we report a novel bat-origin CoV causing severe and fatal pneumonia in humans.
DOI: 10.1097/CM9.0000000000000722
PubMed: 32004165
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Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Lan" sort="Chen, Lan" uniqKey="Chen L" first="Lan" last="Chen">Lan Chen</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yi Wei" sort="Liu, Yi Wei" uniqKey="Liu Y" first="Yi-Wei" last="Liu">Yi-Wei Liu</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory 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sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xiao Rui" sort="Wang, Xiao Rui" uniqKey="Wang X" first="Xiao-Rui" last="Wang">Xiao-Rui Wang</name><affiliation wicri:level="1"><nlm:affiliation>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000</wicri:regionArea></affiliation></author><author><name sortKey="Dong, Jie" sort="Dong, Jie" uniqKey="Dong J" first="Jie" last="Dong">Jie Dong</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chao Lin" sort="Huang, Chao Lin" uniqKey="Huang C" first="Chao-Lin" last="Huang">Chao-Lin Huang</name><affiliation wicri:level="1"><nlm:affiliation>Jin Yin-tan Hospital of Wuhan, Wuhan, Hubei 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jin Yin-tan Hospital of Wuhan, Wuhan, Hubei 430022</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jian Ping" sort="Zhao, Jian Ping" uniqKey="Zhao J" first="Jian-Ping" last="Zhao">Jian-Ping Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Yi" sort="Hu, Yi" uniqKey="Hu Y" first="Yi" last="Hu">Yi Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Zhen Shun" sort="Cheng, Zhen Shun" uniqKey="Cheng Z" first="Zhen-Shun" last="Cheng">Zhen-Shun Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Lin Lin" sort="Liu, Lin Lin" uniqKey="Liu L" first="Lin-Lin" last="Liu">Lin-Lin Liu</name><affiliation wicri:level="1"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079</wicri:regionArea></affiliation></author><author><name sortKey="Qian, Zhao Hui" sort="Qian, Zhao Hui" uniqKey="Qian Z" first="Zhao-Hui" last="Qian">Zhao-Hui Qian</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jian Wei" sort="Wang, Jian Wei" uniqKey="Wang J" first="Jian-Wei" last="Wang">Jian-Wei Wang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32004165</idno><idno type="pmid">32004165</idno><idno type="doi">10.1097/CM9.0000000000000722</idno><idno type="wicri:Area/PubMed/Corpus">000266</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000266</idno><idno type="wicri:Area/PubMed/Curation">000266</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.</title><author><name sortKey="Ren, Li Li" sort="Ren, Li Li" uniqKey="Ren L" first="Li-Li" last="Ren">Li-Li Ren</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ye Ming" sort="Wang, Ye Ming" uniqKey="Wang Y" first="Ye-Ming" last="Wang">Ye-Ming Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Zhi Qiang" sort="Wu, Zhi Qiang" uniqKey="Wu Z" first="Zhi-Qiang" last="Wu">Zhi-Qiang Wu</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Xiang, Zi Chun" sort="Xiang, Zi Chun" uniqKey="Xiang Z" first="Zi-Chun" last="Xiang">Zi-Chun Xiang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Teng" sort="Xu, Teng" uniqKey="Xu T" first="Teng" last="Xu">Teng Xu</name><affiliation wicri:level="1"><nlm:affiliation>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Yong Zhong" sort="Jiang, Yong Zhong" uniqKey="Jiang Y" first="Yong-Zhong" last="Jiang">Yong-Zhong Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079</wicri:regionArea></affiliation></author><author><name sortKey="Xiong, Yan" sort="Xiong, Yan" uniqKey="Xiong Y" first="Yan" last="Xiong">Yan Xiong</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Center for Disease Control and Prevention, Wuhan, Hubei 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Center for Disease Control and Prevention, Wuhan, Hubei 430022</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yong Jun" sort="Li, Yong Jun" uniqKey="Li Y" first="Yong-Jun" last="Li">Yong-Jun Li</name><affiliation wicri:level="1"><nlm:affiliation>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xing Wang" sort="Li, Xing Wang" uniqKey="Li X" first="Xing-Wang" last="Li">Xing-Wang Li</name><affiliation wicri:level="1"><nlm:affiliation>Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015</wicri:regionArea></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Guo Hui" sort="Fan, Guo Hui" uniqKey="Fan G" first="Guo-Hui" last="Fan">Guo-Hui Fan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Gu, Xiao Ying" sort="Gu, Xiao Ying" uniqKey="Gu X" first="Xiao-Ying" last="Gu">Xiao-Ying Gu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Xiao, Yan" sort="Xiao, Yan" uniqKey="Xiao Y" first="Yan" last="Xiao">Yan Xiao</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Jiu Yang" sort="Xu, Jiu Yang" uniqKey="Xu J" first="Jiu-Yang" last="Xu">Jiu-Yang Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, 100084, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, 100084</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xin Ming" sort="Wang, Xin Ming" uniqKey="Wang X" first="Xin-Ming" last="Wang">Xin-Ming Wang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Chao" sort="Wu, Chao" uniqKey="Wu C" first="Chao" last="Wu">Chao Wu</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Lan" sort="Chen, Lan" uniqKey="Chen L" first="Lan" last="Chen">Lan Chen</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yi Wei" sort="Liu, Yi Wei" uniqKey="Liu Y" first="Yi-Wei" last="Liu">Yi-Wei Liu</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Bo" sort="Liu, Bo" uniqKey="Liu B" first="Bo" last="Liu">Bo Liu</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xiao Rui" sort="Wang, Xiao Rui" uniqKey="Wang X" first="Xiao-Rui" last="Wang">Xiao-Rui Wang</name><affiliation wicri:level="1"><nlm:affiliation>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000</wicri:regionArea></affiliation></author><author><name sortKey="Dong, Jie" sort="Dong, Jie" uniqKey="Dong J" first="Jie" last="Dong">Jie Dong</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chao Lin" sort="Huang, Chao Lin" uniqKey="Huang C" first="Chao-Lin" last="Huang">Chao-Lin Huang</name><affiliation wicri:level="1"><nlm:affiliation>Jin Yin-tan Hospital of Wuhan, Wuhan, Hubei 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jin Yin-tan Hospital of Wuhan, Wuhan, Hubei 430022</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jian Ping" sort="Zhao, Jian Ping" uniqKey="Zhao J" first="Jian-Ping" last="Zhao">Jian-Ping Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Yi" sort="Hu, Yi" uniqKey="Hu Y" first="Yi" last="Hu">Yi Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Zhen Shun" sort="Cheng, Zhen Shun" uniqKey="Cheng Z" first="Zhen-Shun" last="Cheng">Zhen-Shun Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Lin Lin" sort="Liu, Lin Lin" uniqKey="Liu L" first="Lin-Lin" last="Liu">Lin-Lin Liu</name><affiliation wicri:level="1"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079</wicri:regionArea></affiliation></author><author><name sortKey="Qian, Zhao Hui" sort="Qian, Zhao Hui" uniqKey="Qian Z" first="Zhao-Hui" last="Qian">Zhao-Hui Qian</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Jian Wei" sort="Wang, Jian Wei" uniqKey="Wang J" first="Jian-Wei" last="Wang">Jian-Wei Wang</name><affiliation wicri:level="1"><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730</wicri:regionArea></affiliation></author></analytic><series><title level="j">Chinese medical journal</title><idno type="eISSN">2542-5641</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human infections with zoonotic coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, have raised great public health concern globally. Here, we report a novel bat-origin CoV causing severe and fatal pneumonia in humans.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32004165</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2542-5641</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Feb</Month><Day>11</Day></PubDate></JournalIssue><Title>Chinese medical journal</Title><ISOAbbreviation>Chin. Med. J.</ISOAbbreviation></Journal><ArticleTitle>Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1097/CM9.0000000000000722</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Human infections with zoonotic coronaviruses (CoVs), including severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV, have raised great public health concern globally. Here, we report a novel bat-origin CoV causing severe and fatal pneumonia in humans.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We collected clinical data and bronchoalveolar lavage (BAL) specimens from five patients with severe pneumonia from Jin Yin-tan Hospital of Wuhan, Hubei province, China. Nucleic acids of the BAL were extracted and subjected to next-generation sequencing. Virus isolation was carried out, and maximum-likelihood phylogenetic trees were constructed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Five patients hospitalized from December 18 to December 29, 2019 presented with fever, cough, and dyspnea accompanied by complications of acute respiratory distress syndrome. Chest radiography revealed diffuse opacities and consolidation. One of these patients died. Sequence results revealed the presence of a previously unknown β-CoV strain in all five patients, with 99.8% to 99.9% nucleotide identities among the isolates. These isolates showed 79.0% nucleotide identity with the sequence of SARS-CoV (GenBank NC_004718) and 51.8% identity with the sequence of MERS-CoV (GenBank NC_019843). The virus is phylogenetically closest to a bat SARS-like CoV (SL-ZC45, GenBank MG772933) with 87.6% to 87.7% nucleotide identity, but is in a separate clade. Moreover, these viruses have a single intact open reading frame gene 8, as a further indicator of bat-origin CoVs. However, the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV, indicating that these viruses might use the same receptor.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Li-Li</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ye-Ming</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Zhi-Qiang</ForeName><Initials>ZQ</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Zi-Chun</ForeName><Initials>ZC</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Teng</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Yong-Zhong</ForeName><Initials>YZ</Initials><AffiliationInfo><Affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Wuhan Center for Disease Control and Prevention, Wuhan, Hubei 430022, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yong-Jun</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>Vision Medicals Co., Ltd, Guangzhou, Guangdong 510000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xing-Wang</ForeName><Initials>XW</Initials><AffiliationInfo><Affiliation>Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Guo-Hui</ForeName><Initials>GH</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100029, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Xiao-Ying</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100029, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Jiu-Yang</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, 100084, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xin-Ming</ForeName><Initials>XM</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Chao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Lan</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>National Health Commission of 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Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Chao-Lin</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Jin Yin-tan Hospital of Wuhan, Wuhan, Hubei 430022, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jian-Ping</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Zhen-Shun</ForeName><Initials>ZS</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Lin-Lin</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qian</LastName><ForeName>Zhao-Hui</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Chuan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Qi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100029, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jian-Wei</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 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