[Comparison of pathological changes and pathogenic mechanisms caused by H1N1 influenza virus, highly pathogenic H5N1 avian influenza virus, SARS-CoV, MERS-CoV and 2019-nCoV coronavirus].
Identifieur interne : 000159 ( PubMed/Curation ); précédent : 000158; suivant : 000160[Comparison of pathological changes and pathogenic mechanisms caused by H1N1 influenza virus, highly pathogenic H5N1 avian influenza virus, SARS-CoV, MERS-CoV and 2019-nCoV coronavirus].
Auteurs : M. Liu [République populaire de Chine] ; R E Feng [République populaire de Chine] ; Q. Li [République populaire de Chine] ; H K Zhang [République populaire de Chine] ; Y G Wang [République populaire de Chine]Source :
- Zhonghua bing li xue za zhi = Chinese journal of pathology [ 0529-5807 ] ; 2020.
DOI: 10.3760/cma.j.cn112151-20200301-00155
PubMed: 32174094
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<Title>Zhonghua bing li xue za zhi = Chinese journal of pathology</Title>
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<ArticleTitle>[Comparison of pathological changes and pathogenic mechanisms caused by H1N1 influenza virus, highly pathogenic H5N1 avian influenza virus, SARS-CoV, MERS-CoV and 2019-nCoV coronavirus].</ArticleTitle>
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<OtherAbstract Type="Publisher" Language="chi"><AbstractText>我国武汉出现的新型冠状病毒肺炎疫情经过迅速发展已对全国造成严重影响,但到目前为止对新型冠状病毒肺炎病理变化和发病机制却知之甚少。本文总结重症流感病毒H1N1、高致病性禽流感病毒H5N1、SARS-CoV、MERS-CoV及2019-nCoV冠状病毒几种引起重大疫情病毒感染性疾病的病理改变,尸检肺组织均表现为弥漫性肺泡损伤(diffuse alveolar damage,DAD),但不同病毒引起的病理表现存在差异,重症流感病毒2009 H1N1病毒与受体α-2,6-SA及α-2,3-SA结合,除DAD病变外,常伴有上呼吸道、气管、支气管和细支气管的炎性病变,且较易合并细菌感染。高致病性禽流感病毒H5N1主要结合α-2,3-SA受体,主要累及肺泡上皮及细支气管,少见上呼吸道及气管、支气管病变,常伴局灶肺出血及肺组织坏死。机化及纤维化较少见。SARS-CoV通过结合血管紧张素转换酶2(ACE2)进入细胞,病变与病程相关,DAD渗出期一般见于病程10~14 d死亡患者。病程大于10 d患者表现为DAD机化期,并常伴有闭塞性细支气管炎伴机化性肺炎样改变及肺泡腔内显著多核巨细胞。SARS-CoV及H5N1感染患者肺外器官均可见脾和淋巴结内淋巴细胞耗竭、急性肾小管坏死、骨髓内噬血细胞现象。.</AbstractText>
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