Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19.
Identifieur interne : 000106 ( PubMed/Curation ); précédent : 000105; suivant : 000107Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19.
Auteurs : Shengwei Yu [République populaire de Chine] ; Junwu Wang [République populaire de Chine] ; Haitao Shen [République populaire de Chine]Source :
- Annals of palliative medicine [ 2224-5839 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Infections à coronavirus.
- Chine, Humains, Lutte contre l'infection, Médecine traditionnelle chinoise, Syndrome respiratoire aigu sévère.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- MESH :
- geographic : China.
- drug therapy : Coronavirus Infections.
- methods : Infection Control, Medicine, Chinese Traditional.
- therapy : Severe Acute Respiratory Syndrome.
- Betacoronavirus, Humans.
Abstract
The novel coronavirus named COVID-19, which originated in Wuhan, China, has spread to many countries around the world. Currently, no effective medical treatment exists to combat this disease. Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. In this article we analyzed the effectiveness and possible molecular mechanisms of CHM formulas for the prevention of COVID-19.
DOI: 10.21037/apm.2020.03.27
PubMed: 32233641
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pubmed:32233641Le document en format XML
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<author><name sortKey="Yu, Shengwei" sort="Yu, Shengwei" uniqKey="Yu S" first="Shengwei" last="Yu">Shengwei Yu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</nlm:affiliation>
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<wicri:regionArea>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004</wicri:regionArea>
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<author><name sortKey="Wang, Junwu" sort="Wang, Junwu" uniqKey="Wang J" first="Junwu" last="Wang">Junwu Wang</name>
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<author><name sortKey="Shen, Haitao" sort="Shen, Haitao" uniqKey="Shen H" first="Haitao" last="Shen">Haitao Shen</name>
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<author><name sortKey="Shen, Haitao" sort="Shen, Haitao" uniqKey="Shen H" first="Haitao" last="Shen">Haitao Shen</name>
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<term>Infection Control (methods)</term>
<term>Medicine, Chinese Traditional (methods)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
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<term>Infections à coronavirus (traitement médicamenteux)</term>
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<term>Médecine traditionnelle chinoise ()</term>
<term>Syndrome respiratoire aigu sévère ()</term>
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<term>Medicine, Chinese Traditional</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract" xml:lang="en">The novel coronavirus named COVID-19, which originated in Wuhan, China, has spread to many countries around the world. Currently, no effective medical treatment exists to combat this disease. Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. In this article we analyzed the effectiveness and possible molecular mechanisms of CHM formulas for the prevention of COVID-19.</div>
</front>
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<DateCompleted><Year>2020</Year>
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<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>2</Issue>
<PubDate><Year>2020</Year>
<Month>Mar</Month>
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<Title>Annals of palliative medicine</Title>
<ISOAbbreviation>Ann Palliat Med</ISOAbbreviation>
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<ArticleTitle>Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The novel coronavirus named COVID-19, which originated in Wuhan, China, has spread to many countries around the world. Currently, no effective medical treatment exists to combat this disease. Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. In this article we analyzed the effectiveness and possible molecular mechanisms of CHM formulas for the prevention of COVID-19.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The active ingredients and action targets of CHM formulas were obtained from the TCMSP database. Genes related to severe acute respiratory syndromes (SARS) and Middle East respiratory syndrome (MERS) were queried on the GeneCards database. The action mechanisms of these genes were predicted using a Gene Ontology (GO)-based functional enrichment and annotation tool and the Kyoto Encyclopedia of Genes and Genomes (KEGG).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">CHM formulas played a positive role in preventing COVID-19 and warrant further application.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our research provides new evidence to support the possible value of CHM formulas for the prevention of COVID-19. However, further clinical studies with large sample sizes are required to verify their effectiveness.</AbstractText>
</Abstract>
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