[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].
Identifieur interne : 002991 ( PubMed/Corpus ); précédent : 002990; suivant : 002992[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].
Auteurs : V I Pantin ; G Ia Solov'Ev ; N V Sats ; V L Surin ; T V Borovkova ; A A Krutov ; E L Zhukova ; N I GrinevaSource :
- Molekuliarnaia biologiia [ 0026-8984 ]
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Single-Stranded.
- chemical , metabolism : DNA, Single-Stranded.
- chemical : Alkylating Agents.
- Adenoviruses, Simian, Animals, Cell Line, Transformed, Cell Transformation, Viral, Mutagenesis, Site-Directed, Nucleic Acid Hybridization, Oncogenes, Phenotype, Polymerase Chain Reaction, Rodentia.
Abstract
Polyalkylating derivatives of single-stranded polynucleotides (30-200-mers) complementary to the long E1 oncogene sequences of simian adenovirus SA7 cause inherited normalization of SH2 and G11 cells transformed with adenovirus SA7; certain deletions in the integrated proviral E1A oncogene were observed in several cases during this process. The transformed cells are indifferent to reagents noncomplementary to the E1 region. Thus polyalkylating derivatives of single-stranded 30-200-mers act as addressed mutagenes which react in a specific way with the integrated complementary DNA sequences of E1 oncogene in transformed rodent cells and realize oncogene-directed mutagenesis in vivo. During this treatment temporary normalized cells reverting to the initial transformed phenotype are also produced.
PubMed: 1795710
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pubmed:1795710Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].</title><author><name sortKey="Pantin, V I" sort="Pantin, V I" uniqKey="Pantin V" first="V I" last="Pantin">V I Pantin</name></author><author><name sortKey="Solov Ev, G Ia" sort="Solov Ev, G Ia" uniqKey="Solov Ev G" first="G Ia" last="Solov'Ev">G Ia Solov'Ev</name></author><author><name sortKey="Sats, N V" sort="Sats, N V" uniqKey="Sats N" first="N V" last="Sats">N V Sats</name></author><author><name sortKey="Surin, V L" sort="Surin, V L" uniqKey="Surin V" first="V L" last="Surin">V L Surin</name></author><author><name sortKey="Borovkova, T V" sort="Borovkova, T V" uniqKey="Borovkova T" first="T V" last="Borovkova">T V Borovkova</name></author><author><name sortKey="Krutov, A A" sort="Krutov, A A" uniqKey="Krutov A" first="A A" last="Krutov">A A Krutov</name></author><author><name sortKey="Zhukova, E L" sort="Zhukova, E L" uniqKey="Zhukova E" first="E L" last="Zhukova">E L Zhukova</name></author><author><name sortKey="Grineva, N I" sort="Grineva, N I" uniqKey="Grineva N" first="N I" last="Grineva">N I Grineva</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1991 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:1795710</idno><idno type="pmid">1795710</idno><idno type="wicri:Area/PubMed/Corpus">002991</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].</title><author><name sortKey="Pantin, V I" sort="Pantin, V I" uniqKey="Pantin V" first="V I" last="Pantin">V I Pantin</name></author><author><name sortKey="Solov Ev, G Ia" sort="Solov Ev, G Ia" uniqKey="Solov Ev G" first="G Ia" last="Solov'Ev">G Ia Solov'Ev</name></author><author><name sortKey="Sats, N V" sort="Sats, N V" uniqKey="Sats N" first="N V" last="Sats">N V Sats</name></author><author><name sortKey="Surin, V L" sort="Surin, V L" uniqKey="Surin V" first="V L" last="Surin">V L Surin</name></author><author><name sortKey="Borovkova, T V" sort="Borovkova, T V" uniqKey="Borovkova T" first="T V" last="Borovkova">T V Borovkova</name></author><author><name sortKey="Krutov, A A" sort="Krutov, A A" uniqKey="Krutov A" first="A A" last="Krutov">A A Krutov</name></author><author><name sortKey="Zhukova, E L" sort="Zhukova, E L" uniqKey="Zhukova E" first="E L" last="Zhukova">E L Zhukova</name></author><author><name sortKey="Grineva, N I" sort="Grineva, N I" uniqKey="Grineva N" first="N I" last="Grineva">N I Grineva</name></author></analytic><series><title level="j">Molekuliarnaia biologiia</title><idno type="ISSN">0026-8984</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviruses, Simian</term><term>Alkylating Agents</term><term>Animals</term><term>Cell Line, Transformed</term><term>Cell Transformation, Viral</term><term>DNA, Single-Stranded (genetics)</term><term>DNA, Single-Stranded (metabolism)</term><term>Mutagenesis, Site-Directed</term><term>Nucleic Acid Hybridization</term><term>Oncogenes</term><term>Phenotype</term><term>Polymerase Chain Reaction</term><term>Rodentia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Single-Stranded</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA, Single-Stranded</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Alkylating Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adenoviruses, Simian</term><term>Animals</term><term>Cell Line, Transformed</term><term>Cell Transformation, Viral</term><term>Mutagenesis, Site-Directed</term><term>Nucleic Acid Hybridization</term><term>Oncogenes</term><term>Phenotype</term><term>Polymerase Chain Reaction</term><term>Rodentia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polyalkylating derivatives of single-stranded polynucleotides (30-200-mers) complementary to the long E1 oncogene sequences of simian adenovirus SA7 cause inherited normalization of SH2 and G11 cells transformed with adenovirus SA7; certain deletions in the integrated proviral E1A oncogene were observed in several cases during this process. The transformed cells are indifferent to reagents noncomplementary to the E1 region. Thus polyalkylating derivatives of single-stranded 30-200-mers act as addressed mutagenes which react in a specific way with the integrated complementary DNA sequences of E1 oncogene in transformed rodent cells and realize oncogene-directed mutagenesis in vivo. During this treatment temporary normalized cells reverting to the initial transformed phenotype are also produced.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1795710</PMID><DateCompleted><Year>1992</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0026-8984</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>4</Issue><PubDate><MedlineDate>1991 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>Molekuliarnaia biologiia</Title><ISOAbbreviation>Mol. Biol. (Mosk.)</ISOAbbreviation></Journal><ArticleTitle>[Oncogene-directed mutagenesis in vivo. Polyalkylating derivatives of short single-stranded polynucleotides, complementary E1-adeno-oncogene, in the normalization of adenovirus-transformed rodent cell lines].</ArticleTitle><Pagination><MedlinePgn>960-73</MedlinePgn></Pagination><Abstract><AbstractText>Polyalkylating derivatives of single-stranded polynucleotides (30-200-mers) complementary to the long E1 oncogene sequences of simian adenovirus SA7 cause inherited normalization of SH2 and G11 cells transformed with adenovirus SA7; certain deletions in the integrated proviral E1A oncogene were observed in several cases during this process. The transformed cells are indifferent to reagents noncomplementary to the E1 region. Thus polyalkylating derivatives of single-stranded 30-200-mers act as addressed mutagenes which react in a specific way with the integrated complementary DNA sequences of E1 oncogene in transformed rodent cells and realize oncogene-directed mutagenesis in vivo. During this treatment temporary normalized cells reverting to the initial transformed phenotype are also produced.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pantin</LastName><ForeName>V I</ForeName><Initials>VI</Initials></Author><Author ValidYN="Y"><LastName>Solov'ev</LastName><ForeName>G Ia</ForeName><Initials>GIa</Initials></Author><Author ValidYN="Y"><LastName>Sats</LastName><ForeName>N V</ForeName><Initials>NV</Initials></Author><Author ValidYN="Y"><LastName>Surin</LastName><ForeName>V L</ForeName><Initials>VL</Initials></Author><Author ValidYN="Y"><LastName>Borovkova</LastName><ForeName>T V</ForeName><Initials>TV</Initials></Author><Author ValidYN="Y"><LastName>Krutov</LastName><ForeName>A A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Zhukova</LastName><ForeName>E L</ForeName><Initials>EL</Initials></Author><Author ValidYN="Y"><LastName>Grineva</LastName><ForeName>N I</ForeName><Initials>NI</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Onkogen-naprovlennyĭ mutagenez in vivo. Polialkiliruiushchie proizvodnye korotkikh odnotiazhevykh polinukleotidov, komplementarnykh E1- adenoonkogenu, v normalizatsii transformirovannykh adenovirusom kloetochnykh liniĭ gryzunov.</VernacularTitle></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Mol Biol (Mosk)</MedlineTA><NlmUniqueID>0105454</NlmUniqueID><ISSNLinking>0026-8984</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000477">Alkylating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004277">DNA, Single-Stranded</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000261" MajorTopicYN="N">Adenoviruses, Simian</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000477" MajorTopicYN="N">Alkylating Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002461" MajorTopicYN="N">Cell Line, Transformed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002472" MajorTopicYN="N">Cell Transformation, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004277" MajorTopicYN="N">DNA, Single-Stranded</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016297" MajorTopicYN="Y">Mutagenesis, Site-Directed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009857" MajorTopicYN="Y">Oncogenes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012377" MajorTopicYN="N">Rodentia</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1795710</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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