Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Identifieur interne : 002544 ( PubMed/Corpus ); précédent : 002543; suivant : 002545Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Auteurs : D. Rejman ; J. Snásel ; R. Liboska ; Z. Tocík ; O. Paces ; S. Králíková ; M. Rinnová ; P. Kois ; I. RosenbergSource :
- Nucleosides, nucleotides & nucleic acids [ 1525-7770 ]
English descriptors
- KwdEn :
- Adenosine Monophosphate (chemistry), Cross-Linking Reagents (chemistry), Nucleic Acid Hybridization, Oligonucleotides, Antisense (chemical synthesis), Oligonucleotides, Antisense (chemistry), Oligonucleotides, Antisense (metabolism), Organophosphonates (chemistry), Ribonuclease H (metabolism), Thymidine Monophosphate (chemistry).
- MESH :
- chemical , chemical synthesis : Oligonucleotides, Antisense.
- chemical , chemistry : Adenosine Monophosphate, Cross-Linking Reagents, Oligonucleotides, Antisense, Organophosphonates, Thymidine Monophosphate.
- chemical , metabolism : Oligonucleotides, Antisense, Ribonuclease H.
- Nucleic Acid Hybridization.
Abstract
Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
DOI: 10.1081/NCN-100002437
PubMed: 11563123
Links to Exploration step
pubmed:11563123Le document en format XML
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<author><name sortKey="Snasel, J" sort="Snasel, J" uniqKey="Snasel J" first="J" last="Snásel">J. Snásel</name>
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<author><name sortKey="Liboska, R" sort="Liboska, R" uniqKey="Liboska R" first="R" last="Liboska">R. Liboska</name>
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<author><name sortKey="Tocik, Z" sort="Tocik, Z" uniqKey="Tocik Z" first="Z" last="Tocík">Z. Tocík</name>
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<author><name sortKey="Paces, O" sort="Paces, O" uniqKey="Paces O" first="O" last="Paces">O. Paces</name>
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<author><name sortKey="Rinnova, M" sort="Rinnova, M" uniqKey="Rinnova M" first="M" last="Rinnová">M. Rinnová</name>
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<author><name sortKey="Kois, P" sort="Kois, P" uniqKey="Kois P" first="P" last="Kois">P. Kois</name>
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<author><name sortKey="Rosenberg, I" sort="Rosenberg, I" uniqKey="Rosenberg I" first="I" last="Rosenberg">I. Rosenberg</name>
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<author><name sortKey="Paces, O" sort="Paces, O" uniqKey="Paces O" first="O" last="Paces">O. Paces</name>
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<term>Oligonucleotides, Antisense (chemical synthesis)</term>
<term>Oligonucleotides, Antisense (chemistry)</term>
<term>Oligonucleotides, Antisense (metabolism)</term>
<term>Organophosphonates (chemistry)</term>
<term>Ribonuclease H (metabolism)</term>
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<term>Organophosphonates</term>
<term>Thymidine Monophosphate</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oligonucleotides, Antisense</term>
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<front><div type="abstract" xml:lang="en">Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.</div>
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<Abstract><AbstractText>Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.</AbstractText>
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