Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Identifieur interne : 002544 ( PubMed/Corpus ); précédent : 002543; suivant : 002545Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Auteurs : D. Rejman ; J. Snásel ; R. Liboska ; Z. Tocík ; O. Paces ; S. Králíková ; M. Rinnová ; P. Kois ; I. RosenbergSource :
- Nucleosides, nucleotides & nucleic acids [ 1525-7770 ]
English descriptors
- KwdEn :
- Adenosine Monophosphate (chemistry), Cross-Linking Reagents (chemistry), Nucleic Acid Hybridization, Oligonucleotides, Antisense (chemical synthesis), Oligonucleotides, Antisense (chemistry), Oligonucleotides, Antisense (metabolism), Organophosphonates (chemistry), Ribonuclease H (metabolism), Thymidine Monophosphate (chemistry).
- MESH :
- chemical , chemical synthesis : Oligonucleotides, Antisense.
- chemical , chemistry : Adenosine Monophosphate, Cross-Linking Reagents, Oligonucleotides, Antisense, Organophosphonates, Thymidine Monophosphate.
- chemical , metabolism : Oligonucleotides, Antisense, Ribonuclease H.
- Nucleic Acid Hybridization.
Abstract
Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
DOI: 10.1081/NCN-100002437
PubMed: 11563123
Links to Exploration step
pubmed:11563123Le document en format XML
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Paces</name></author><author><name sortKey="Kralikova, S" sort="Kralikova, S" uniqKey="Kralikova S" first="S" last="Králíková">S. Králíková</name></author><author><name sortKey="Rinnova, M" sort="Rinnova, M" uniqKey="Rinnova M" first="M" last="Rinnová">M. Rinnová</name></author><author><name sortKey="Kois, P" sort="Kois, P" uniqKey="Kois P" first="P" last="Kois">P. Kois</name></author><author><name sortKey="Rosenberg, I" sort="Rosenberg, I" uniqKey="Rosenberg I" first="I" last="Rosenberg">I. Rosenberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2001 Apr-Jul</MedlineDate></PubDate></date><idno type="RBID">pubmed:11563123</idno><idno type="pmid">11563123</idno><idno type="doi">10.1081/NCN-100002437</idno><idno type="wicri:Area/PubMed/Corpus">002544</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002544</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?</title><author><name sortKey="Rejman, D" sort="Rejman, D" uniqKey="Rejman D" first="D" last="Rejman">D. Rejman</name><affiliation><nlm:affiliation>Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Snasel, J" sort="Snasel, J" uniqKey="Snasel J" first="J" last="Snásel">J. Snásel</name></author><author><name sortKey="Liboska, R" sort="Liboska, R" uniqKey="Liboska R" first="R" last="Liboska">R. Liboska</name></author><author><name sortKey="Tocik, Z" sort="Tocik, Z" uniqKey="Tocik Z" first="Z" last="Tocík">Z. Tocík</name></author><author><name sortKey="Paces, O" sort="Paces, O" uniqKey="Paces O" first="O" last="Paces">O. Paces</name></author><author><name sortKey="Kralikova, S" sort="Kralikova, S" uniqKey="Kralikova S" first="S" last="Králíková">S. Králíková</name></author><author><name sortKey="Rinnova, M" sort="Rinnova, M" uniqKey="Rinnova M" first="M" last="Rinnová">M. Rinnová</name></author><author><name sortKey="Kois, P" sort="Kois, P" uniqKey="Kois P" first="P" last="Kois">P. Kois</name></author><author><name sortKey="Rosenberg, I" sort="Rosenberg, I" uniqKey="Rosenberg I" first="I" last="Rosenberg">I. Rosenberg</name></author></analytic><series><title level="j">Nucleosides, nucleotides & nucleic acids</title><idno type="ISSN">1525-7770</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Monophosphate (chemistry)</term><term>Cross-Linking Reagents (chemistry)</term><term>Nucleic Acid Hybridization</term><term>Oligonucleotides, Antisense (chemical synthesis)</term><term>Oligonucleotides, Antisense (chemistry)</term><term>Oligonucleotides, Antisense (metabolism)</term><term>Organophosphonates (chemistry)</term><term>Ribonuclease H (metabolism)</term><term>Thymidine Monophosphate (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Oligonucleotides, Antisense</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Monophosphate</term><term>Cross-Linking Reagents</term><term>Oligonucleotides, Antisense</term><term>Organophosphonates</term><term>Thymidine Monophosphate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oligonucleotides, Antisense</term><term>Ribonuclease H</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Nucleic Acid Hybridization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11563123</PMID><DateCompleted><Year>2002</Year><Month>01</Month><Day>09</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1525-7770</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>4-7</Issue><PubDate><MedlineDate>2001 Apr-Jul</MedlineDate></PubDate></JournalIssue><Title>Nucleosides, nucleotides & nucleic acids</Title><ISOAbbreviation>Nucleosides Nucleotides Nucleic Acids</ISOAbbreviation></Journal><ArticleTitle>Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?</ArticleTitle><Pagination><MedlinePgn>819-23</MedlinePgn></Pagination><Abstract><AbstractText>Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rejman</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snásel</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Liboska</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Tocík</LastName><ForeName>Z</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Paces</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Králíková</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rinnová</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kois</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Rosenberg</LastName><ForeName>I</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nucleosides Nucleotides Nucleic Acids</MedlineTA><NlmUniqueID>100892832</NlmUniqueID><ISSNLinking>1525-7770</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003432">Cross-Linking Reagents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016376">Oligonucleotides, Antisense</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D063065">Organophosphonates</NameOfSubstance></Chemical><Chemical><RegistryNumber>365-07-1</RegistryNumber><NameOfSubstance UI="D013938">Thymidine Monophosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>415SHH325A</RegistryNumber><NameOfSubstance UI="D000249">Adenosine Monophosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.26.4</RegistryNumber><NameOfSubstance UI="D016914">Ribonuclease H</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000249" MajorTopicYN="N">Adenosine Monophosphate</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003432" MajorTopicYN="N">Cross-Linking Reagents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009693" MajorTopicYN="N">Nucleic Acid Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016376" MajorTopicYN="N">Oligonucleotides, Antisense</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D063065" MajorTopicYN="N">Organophosphonates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016914" MajorTopicYN="N">Ribonuclease H</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013938" MajorTopicYN="N">Thymidine Monophosphate</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>9</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>1</Month><Day>10</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>9</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11563123</ArticleId><ArticleId IdType="doi">10.1081/NCN-100002437</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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