Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.
Identifieur interne : 002461 ( PubMed/Corpus ); précédent : 002460; suivant : 002462Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.
Auteurs : Li Ouyang ; Xinyuan Yi ; Xianfang Zeng ; Jinchun Zhou ; Qinlin Wang ; Larry McreynoldsSource :
- Chinese medical journal [ 0366-6999 ] ; 2003.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Helminth Proteins, Vaccines.
- chemical : Epitopes, Peptide Library.
- immunology : Schistosoma japonicum.
- parasitology : Arvicolinae.
- prevention & control : Schistosomiasis japonica.
- Animals.
Abstract
To obtain peptide mimicking epitopes of Schistosoma japonicum (S. japonicum) through screening of a phage peptide library and to test their potential for induction of protection.
PubMed: 12667407
Links to Exploration step
pubmed:12667407Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.</title>
<author><name sortKey="Ouyang, Li" sort="Ouyang, Li" uniqKey="Ouyang L" first="Li" last="Ouyang">Li Ouyang</name>
<affiliation><nlm:affiliation>Department of Pathogen Biology, Central South University Xiangya School of Medicine, Changsha 410078, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yi, Xinyuan" sort="Yi, Xinyuan" uniqKey="Yi X" first="Xinyuan" last="Yi">Xinyuan Yi</name>
</author>
<author><name sortKey="Zeng, Xianfang" sort="Zeng, Xianfang" uniqKey="Zeng X" first="Xianfang" last="Zeng">Xianfang Zeng</name>
</author>
<author><name sortKey="Zhou, Jinchun" sort="Zhou, Jinchun" uniqKey="Zhou J" first="Jinchun" last="Zhou">Jinchun Zhou</name>
</author>
<author><name sortKey="Wang, Qinlin" sort="Wang, Qinlin" uniqKey="Wang Q" first="Qinlin" last="Wang">Qinlin Wang</name>
</author>
<author><name sortKey="Mcreynolds, Larry" sort="Mcreynolds, Larry" uniqKey="Mcreynolds L" first="Larry" last="Mcreynolds">Larry Mcreynolds</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.</title>
<author><name sortKey="Ouyang, Li" sort="Ouyang, Li" uniqKey="Ouyang L" first="Li" last="Ouyang">Li Ouyang</name>
<affiliation><nlm:affiliation>Department of Pathogen Biology, Central South University Xiangya School of Medicine, Changsha 410078, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yi, Xinyuan" sort="Yi, Xinyuan" uniqKey="Yi X" first="Xinyuan" last="Yi">Xinyuan Yi</name>
</author>
<author><name sortKey="Zeng, Xianfang" sort="Zeng, Xianfang" uniqKey="Zeng X" first="Xianfang" last="Zeng">Xianfang Zeng</name>
</author>
<author><name sortKey="Zhou, Jinchun" sort="Zhou, Jinchun" uniqKey="Zhou J" first="Jinchun" last="Zhou">Jinchun Zhou</name>
</author>
<author><name sortKey="Wang, Qinlin" sort="Wang, Qinlin" uniqKey="Wang Q" first="Qinlin" last="Wang">Qinlin Wang</name>
</author>
<author><name sortKey="Mcreynolds, Larry" sort="Mcreynolds, Larry" uniqKey="Mcreynolds L" first="Larry" last="Mcreynolds">Larry Mcreynolds</name>
</author>
</analytic>
<series><title level="j">Chinese medical journal</title>
<idno type="ISSN">0366-6999</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Arvicolinae (parasitology)</term>
<term>Epitopes</term>
<term>Helminth Proteins (immunology)</term>
<term>Peptide Library</term>
<term>Schistosoma japonicum (immunology)</term>
<term>Schistosomiasis japonica (prevention & control)</term>
<term>Vaccines (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Helminth Proteins</term>
<term>Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Epitopes</term>
<term>Peptide Library</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Schistosoma japonicum</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Arvicolinae</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Schistosomiasis japonica</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
</keywords>
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<front><div type="abstract" xml:lang="en">To obtain peptide mimicking epitopes of Schistosoma japonicum (S. japonicum) through screening of a phage peptide library and to test their potential for induction of protection.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12667407</PMID>
<DateCompleted><Year>2003</Year>
<Month>04</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0366-6999</ISSN>
<JournalIssue CitedMedium="Print"><Volume>116</Volume>
<Issue>1</Issue>
<PubDate><Year>2003</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Chinese medical journal</Title>
<ISOAbbreviation>Chin. Med. J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.</ArticleTitle>
<Pagination><MedlinePgn>138-41</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To obtain peptide mimicking epitopes of Schistosoma japonicum (S. japonicum) through screening of a phage peptide library and to test their potential for induction of protection.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">S. japonicum infected sera from Microtus fortis (IMFS) and normal sera from Microtus fortis (NMFS) were used respectively to screen a 12-mers random peptide library by testing the reactivity of anti-S. japonicum serum with the phagotopes. After three rounds of biopanning, the pooled phages were used to immunize mice, after which challenge infection was performed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 12 randomly picked clones, 10 clones selected using IMFS and 7 clones selected using NMFS were shown to be antigenic. Significant reduction in adult worms (22.6%) and a high reduction (68.9%) in liver eggs were achieved following immunization with phages screened with IMFS. However, no protection was elicited by those selected with NMFS.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results show that the phagotopes are both antigenic and immunogenic, suggesting a potential use of phage displayed peptide as novel vaccines against S. japonicum.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ouyang</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pathogen Biology, Central South University Xiangya School of Medicine, Changsha 410078, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yi</LastName>
<ForeName>Xinyuan</ForeName>
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<Author ValidYN="Y"><LastName>Zeng</LastName>
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<Author ValidYN="Y"><LastName>Zhou</LastName>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Qinlin</ForeName>
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<Author ValidYN="Y"><LastName>McReynolds</LastName>
<ForeName>Larry</ForeName>
<Initials>L</Initials>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<MedlineJournalInfo><Country>China</Country>
<MedlineTA>Chin Med J (Engl)</MedlineTA>
<NlmUniqueID>7513795</NlmUniqueID>
<ISSNLinking>0366-6999</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000939">Epitopes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015801">Helminth Proteins</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003411" MajorTopicYN="N">Arvicolinae</DescriptorName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015801" MajorTopicYN="N">Helminth Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019151" MajorTopicYN="Y">Peptide Library</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012549" MajorTopicYN="N">Schistosoma japonicum</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012554" MajorTopicYN="N">Schistosomiasis japonica</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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