Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.
Identifieur interne : 002461 ( PubMed/Corpus ); précédent : 002460; suivant : 002462Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.
Auteurs : Li Ouyang ; Xinyuan Yi ; Xianfang Zeng ; Jinchun Zhou ; Qinlin Wang ; Larry McreynoldsSource :
- Chinese medical journal [ 0366-6999 ] ; 2003.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Helminth Proteins, Vaccines.
- chemical : Epitopes, Peptide Library.
- immunology : Schistosoma japonicum.
- parasitology : Arvicolinae.
- prevention & control : Schistosomiasis japonica.
- Animals.
Abstract
To obtain peptide mimicking epitopes of Schistosoma japonicum (S. japonicum) through screening of a phage peptide library and to test their potential for induction of protection.
PubMed: 12667407
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.</title><author><name sortKey="Ouyang, Li" sort="Ouyang, Li" uniqKey="Ouyang L" first="Li" last="Ouyang">Li Ouyang</name><affiliation><nlm:affiliation>Department of Pathogen Biology, Central South University Xiangya School of Medicine, Changsha 410078, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yi, Xinyuan" sort="Yi, Xinyuan" uniqKey="Yi X" first="Xinyuan" last="Yi">Xinyuan Yi</name></author><author><name sortKey="Zeng, Xianfang" sort="Zeng, Xianfang" uniqKey="Zeng X" first="Xianfang" last="Zeng">Xianfang Zeng</name></author><author><name sortKey="Zhou, Jinchun" sort="Zhou, Jinchun" uniqKey="Zhou J" first="Jinchun" last="Zhou">Jinchun Zhou</name></author><author><name sortKey="Wang, Qinlin" sort="Wang, Qinlin" uniqKey="Wang Q" first="Qinlin" last="Wang">Qinlin Wang</name></author><author><name sortKey="Mcreynolds, Larry" sort="Mcreynolds, Larry" uniqKey="Mcreynolds L" first="Larry" last="Mcreynolds">Larry Mcreynolds</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12667407</idno><idno type="pmid">12667407</idno><idno type="wicri:Area/PubMed/Corpus">002461</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002461</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.</title><author><name sortKey="Ouyang, Li" sort="Ouyang, Li" uniqKey="Ouyang L" first="Li" last="Ouyang">Li Ouyang</name><affiliation><nlm:affiliation>Department of Pathogen Biology, Central South University Xiangya School of Medicine, Changsha 410078, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yi, Xinyuan" sort="Yi, Xinyuan" uniqKey="Yi X" first="Xinyuan" last="Yi">Xinyuan Yi</name></author><author><name sortKey="Zeng, Xianfang" sort="Zeng, Xianfang" uniqKey="Zeng X" first="Xianfang" last="Zeng">Xianfang Zeng</name></author><author><name sortKey="Zhou, Jinchun" sort="Zhou, Jinchun" uniqKey="Zhou J" first="Jinchun" last="Zhou">Jinchun Zhou</name></author><author><name sortKey="Wang, Qinlin" sort="Wang, Qinlin" uniqKey="Wang Q" first="Qinlin" last="Wang">Qinlin Wang</name></author><author><name sortKey="Mcreynolds, Larry" sort="Mcreynolds, Larry" uniqKey="Mcreynolds L" first="Larry" last="Mcreynolds">Larry Mcreynolds</name></author></analytic><series><title level="j">Chinese medical journal</title><idno type="ISSN">0366-6999</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Arvicolinae (parasitology)</term><term>Epitopes</term><term>Helminth Proteins (immunology)</term><term>Peptide Library</term><term>Schistosoma japonicum (immunology)</term><term>Schistosomiasis japonica (prevention & control)</term><term>Vaccines (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Helminth Proteins</term><term>Vaccines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Epitopes</term><term>Peptide Library</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Schistosoma japonicum</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Arvicolinae</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Schistosomiasis japonica</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To obtain peptide mimicking epitopes of Schistosoma japonicum (S. japonicum) through screening of a phage peptide library and to test their potential for induction of protection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12667407</PMID><DateCompleted><Year>2003</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0366-6999</ISSN><JournalIssue CitedMedium="Print"><Volume>116</Volume><Issue>1</Issue><PubDate><Year>2003</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Chinese medical journal</Title><ISOAbbreviation>Chin. Med. J.</ISOAbbreviation></Journal><ArticleTitle>Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum.</ArticleTitle><Pagination><MedlinePgn>138-41</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To obtain peptide mimicking epitopes of Schistosoma japonicum (S. japonicum) through screening of a phage peptide library and to test their potential for induction of protection.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">S. japonicum infected sera from Microtus fortis (IMFS) and normal sera from Microtus fortis (NMFS) were used respectively to screen a 12-mers random peptide library by testing the reactivity of anti-S. japonicum serum with the phagotopes. After three rounds of biopanning, the pooled phages were used to immunize mice, after which challenge infection was performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 12 randomly picked clones, 10 clones selected using IMFS and 7 clones selected using NMFS were shown to be antigenic. Significant reduction in adult worms (22.6%) and a high reduction (68.9%) in liver eggs were achieved following immunization with phages screened with IMFS. However, no protection was elicited by those selected with NMFS.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results show that the phagotopes are both antigenic and immunogenic, suggesting a potential use of phage displayed peptide as novel vaccines against S. japonicum.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ouyang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pathogen Biology, Central South University Xiangya School of Medicine, Changsha 410078, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yi</LastName><ForeName>Xinyuan</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Xianfang</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jinchun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qinlin</ForeName><Initials>Q</Initials></Author><Author ValidYN="Y"><LastName>McReynolds</LastName><ForeName>Larry</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin Med J (Engl)</MedlineTA><NlmUniqueID>7513795</NlmUniqueID><ISSNLinking>0366-6999</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015801">Helminth Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019151">Peptide Library</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014612">Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003411" MajorTopicYN="N">Arvicolinae</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015801" MajorTopicYN="N">Helminth Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019151" MajorTopicYN="Y">Peptide Library</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012549" MajorTopicYN="N">Schistosoma japonicum</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012554" MajorTopicYN="N">Schistosomiasis japonica</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>2</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>4</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>2</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12667407</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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