No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies.
Identifieur interne : 002176 ( PubMed/Corpus ); précédent : 002175; suivant : 002177No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies.
Auteurs : Janet W. De Beukelaar ; Georges M. Verjans ; Yvette Van Norden ; Johannes C. Milikan ; Jaco Kraan ; Herbert Hooijkaas ; Kees Sintnicolaas ; Jan W. Gratama ; Peter A. Sillevis SmittSource :
- Cancer immunology, immunotherapy : CII [ 0340-7004 ] ; 2007.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies (blood), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Child, Child, Preschool, ELAV Proteins (blood), ELAV Proteins (immunology), Female, Flow Cytometry, Humans, Leukocytes, Mononuclear (immunology), Male, Middle Aged, Paraneoplastic Syndromes (blood), Paraneoplastic Syndromes (immunology), T-Lymphocyte Subsets (immunology).
- MESH :
- chemical , blood : Antibodies, ELAV Proteins.
- blood : Paraneoplastic Syndromes.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, ELAV Proteins, Leukocytes, Mononuclear, Paraneoplastic Syndromes, T-Lymphocyte Subsets.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Flow Cytometry, Humans, Male, Middle Aged.
Abstract
In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies (Hu-PNS), Hu antigens expressed by the tumour hypothetically trigger an immune response that also reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized CD8(+ )T cell-mediated immune pathogenesis of these syndromes, we searched for circulating HuD-specific CD8(+) T cells in a large cohort of Hu-PNS patients and controls.
DOI: 10.1007/s00262-007-0295-2
PubMed: 17597332
Links to Exploration step
pubmed:17597332Le document en format XML
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<author><name sortKey="De Beukelaar, Janet W" sort="De Beukelaar, Janet W" uniqKey="De Beukelaar J" first="Janet W" last="De Beukelaar">Janet W. De Beukelaar</name>
<affiliation><nlm:affiliation>Department of Medical Oncology, Room E-2-80B, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands.</nlm:affiliation>
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<author><name sortKey="Verjans, Georges M" sort="Verjans, Georges M" uniqKey="Verjans G" first="Georges M" last="Verjans">Georges M. Verjans</name>
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<author><name sortKey="Van Norden, Yvette" sort="Van Norden, Yvette" uniqKey="Van Norden Y" first="Yvette" last="Van Norden">Yvette Van Norden</name>
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<author><name sortKey="Gratama, Jan W" sort="Gratama, Jan W" uniqKey="Gratama J" first="Jan W" last="Gratama">Jan W. Gratama</name>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies (blood)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>ELAV Proteins (blood)</term>
<term>ELAV Proteins (immunology)</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Humans</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Paraneoplastic Syndromes (blood)</term>
<term>Paraneoplastic Syndromes (immunology)</term>
<term>T-Lymphocyte Subsets (immunology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies</term>
<term>ELAV Proteins</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Paraneoplastic Syndromes</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
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<term>Paraneoplastic Syndromes</term>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
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<front><div type="abstract" xml:lang="en">In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies (Hu-PNS), Hu antigens expressed by the tumour hypothetically trigger an immune response that also reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized CD8(+ )T cell-mediated immune pathogenesis of these syndromes, we searched for circulating HuD-specific CD8(+) T cells in a large cohort of Hu-PNS patients and controls.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17597332</PMID>
<DateCompleted><Year>2007</Year>
<Month>09</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0340-7004</ISSN>
<JournalIssue CitedMedium="Print"><Volume>56</Volume>
<Issue>9</Issue>
<PubDate><Year>2007</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Cancer immunology, immunotherapy : CII</Title>
<ISOAbbreviation>Cancer Immunol. Immunother.</ISOAbbreviation>
</Journal>
<ArticleTitle>No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies.</ArticleTitle>
<Pagination><MedlinePgn>1501-6</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies (Hu-PNS), Hu antigens expressed by the tumour hypothetically trigger an immune response that also reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized CD8(+ )T cell-mediated immune pathogenesis of these syndromes, we searched for circulating HuD-specific CD8(+) T cells in a large cohort of Hu-PNS patients and controls.</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Blood was tested from 43 Hu-PNS patients, 31 Hu antibody negative SCLC patients without PNS and 54 healthy controls. Peripheral blood mononuclear cells (PBMC) were stimulated with HuD protein-spanning peptide pools (15-mers) and individual HuD-derived peptides (9-mers) and analysed by cytokine flow cytometry and interferon-gamma ELISPOT-assays. Additionally, HuD-based Class I HLA multimers were used to visualize HuD-specific CD8(+) T cells.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">No HuD-specific CD8(+ )T cells could be detected in the blood of Hu-PNS patients or controls.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results do not support a role for HuD-specific CD8(+) T cells in Hu-PNS. Further studies should focus on the detection of circulating HuD-specific CD4(+ )T cells and examine the antigen specificity of T cells in affected tissues.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Beukelaar</LastName>
<ForeName>Janet W</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>Department of Medical Oncology, Room E-2-80B, Erasmus University Medical Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verjans</LastName>
<ForeName>Georges M</ForeName>
<Initials>GM</Initials>
</Author>
<Author ValidYN="Y"><LastName>van Norden</LastName>
<ForeName>Yvette</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Milikan</LastName>
<ForeName>Johannes C</ForeName>
<Initials>JC</Initials>
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<Author ValidYN="Y"><LastName>Kraan</LastName>
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<Author ValidYN="Y"><LastName>Hooijkaas</LastName>
<ForeName>Herbert</ForeName>
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<ForeName>Kees</ForeName>
<Initials>K</Initials>
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<Author ValidYN="Y"><LastName>Gratama</LastName>
<ForeName>Jan W</ForeName>
<Initials>JW</Initials>
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<Author ValidYN="Y"><LastName>Sillevis Smitt</LastName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D010257" MajorTopicYN="N">Paraneoplastic Syndromes</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D016176" MajorTopicYN="N">T-Lymphocyte Subsets</DescriptorName>
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