DNA damage by low-energy electron impact: dependence on guanine content.
Identifieur interne : 002000 ( PubMed/Corpus ); précédent : 001F99; suivant : 002001DNA damage by low-energy electron impact: dependence on guanine content.
Auteurs : T. Solomun ; H. Seitz ; H. SturmSource :
- The journal of physical chemistry. B [ 1520-6106 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Guanine.
- chemical , chemistry : DNA, Single-Stranded, Gold, Guanine, Oligonucleotides.
- chemical , radiation effects : DNA, Single-Stranded, Oligonucleotides.
- adverse effects : Electrons.
- DNA Damage, Surface Properties, Thermodynamics.
Abstract
Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n=1-4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.
DOI: 10.1021/jp905263x
PubMed: 19645513
Links to Exploration step
pubmed:19645513Le document en format XML
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<author><name sortKey="Seitz, H" sort="Seitz, H" uniqKey="Seitz H" first="H" last="Seitz">H. Seitz</name>
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<author><name sortKey="Sturm, H" sort="Sturm, H" uniqKey="Sturm H" first="H" last="Sturm">H. Sturm</name>
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<series><title level="j">The journal of physical chemistry. B</title>
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<term>Electrons (adverse effects)</term>
<term>Gold (chemistry)</term>
<term>Guanine (analysis)</term>
<term>Guanine (chemistry)</term>
<term>Oligonucleotides (chemistry)</term>
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<term>Surface Properties</term>
<term>Thermodynamics</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Single-Stranded</term>
<term>Gold</term>
<term>Guanine</term>
<term>Oligonucleotides</term>
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<keywords scheme="MESH" type="chemical" qualifier="radiation effects" xml:lang="en"><term>DNA, Single-Stranded</term>
<term>Oligonucleotides</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electrons</term>
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<front><div type="abstract" xml:lang="en">Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n=1-4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.</div>
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<Title>The journal of physical chemistry. B</Title>
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<Abstract><AbstractText>Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n=1-4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.</AbstractText>
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