MersV1, PubMed, Corpus, bibRecord, 002000

DNA damage by low-energy electron impact: dependence on guanine content.

Identifieur interne : 002000 ( PubMed/Corpus ); précédent : 001F99; suivant : 002001

DNA damage by low-energy electron impact: dependence on guanine content.

Auteurs : T. Solomun ; H. Seitz ; H. Sturm

Source :

The journal of physical chemistry. B [ 1520-6106 ] ; 2009.

RBID : pubmed:19645513

English descriptors

KwdEn :
- DNA Damage, DNA, Single-Stranded (chemistry), DNA, Single-Stranded (radiation effects), Electrons (adverse effects), Gold (chemistry), Guanine (analysis), Guanine (chemistry), Oligonucleotides (chemistry), Oligonucleotides (radiation effects), Surface Properties, Thermodynamics.
MESH :
- chemical , analysis : Guanine.
- chemical , chemistry : DNA, Single-Stranded, Gold, Guanine, Oligonucleotides.
- chemical , radiation effects : DNA, Single-Stranded, Oligonucleotides.
- adverse effects : Electrons.
- DNA Damage, Surface Properties, Thermodynamics.

Abstract

Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n=1-4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.

DOI: 10.1021/jp905263x
PubMed: 19645513

Links to Exploration step

pubmed:19645513

Le document en format XML

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<author><name sortKey="Solomun, T" sort="Solomun, T" uniqKey="Solomun T" first="T" last="Solomun">T. Solomun</name>
<affiliation><nlm:affiliation>Institute of Chemistry and Biochemistry, Free University Berlin, Takustrasse 3, D-14195 Berlin, Germany. solomun@chemie.fu-berlin.de</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Seitz, H" sort="Seitz, H" uniqKey="Seitz H" first="H" last="Seitz">H. Seitz</name>
</author>
<author><name sortKey="Sturm, H" sort="Sturm, H" uniqKey="Sturm H" first="H" last="Sturm">H. Sturm</name>
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<affiliation><nlm:affiliation>Institute of Chemistry and Biochemistry, Free University Berlin, Takustrasse 3, D-14195 Berlin, Germany. solomun@chemie.fu-berlin.de</nlm:affiliation>
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<author><name sortKey="Seitz, H" sort="Seitz, H" uniqKey="Seitz H" first="H" last="Seitz">H. Seitz</name>
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<author><name sortKey="Sturm, H" sort="Sturm, H" uniqKey="Sturm H" first="H" last="Sturm">H. Sturm</name>
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<series><title level="j">The journal of physical chemistry. B</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA Damage</term>
<term>DNA, Single-Stranded (chemistry)</term>
<term>DNA, Single-Stranded (radiation effects)</term>
<term>Electrons (adverse effects)</term>
<term>Gold (chemistry)</term>
<term>Guanine (analysis)</term>
<term>Guanine (chemistry)</term>
<term>Oligonucleotides (chemistry)</term>
<term>Oligonucleotides (radiation effects)</term>
<term>Surface Properties</term>
<term>Thermodynamics</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Guanine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Single-Stranded</term>
<term>Gold</term>
<term>Guanine</term>
<term>Oligonucleotides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="radiation effects" xml:lang="en"><term>DNA, Single-Stranded</term>
<term>Oligonucleotides</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electrons</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>DNA Damage</term>
<term>Surface Properties</term>
<term>Thermodynamics</term>
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<front><div type="abstract" xml:lang="en">Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n=1-4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.</div>
</front>
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<DateCompleted><Year>2010</Year>
<Month>02</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1520-6106</ISSN>
<JournalIssue CitedMedium="Print"><Volume>113</Volume>
<Issue>34</Issue>
<PubDate><Year>2009</Year>
<Month>Aug</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>The journal of physical chemistry. B</Title>
<ISOAbbreviation>J Phys Chem B</ISOAbbreviation>
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<ArticleTitle>DNA damage by low-energy electron impact: dependence on guanine content.</ArticleTitle>
<Pagination><MedlinePgn>11557-9</MedlinePgn>
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<Abstract><AbstractText>Single-stranded DNA oligonucleotides (33-mers) containing different numbers of guanines (n=1-4) were tethered to a gold surface and exposed to 1 eV electrons. The electrons induced DNA damage, which was analyzed with fluorescence and infrared spectroscopy methods. The damage was identified as strand breaks and found to correlate linearly with the number of guanines in the sequence. This sequence dependence indicates that the electron capture by the DNA bases plays an important role in the damage reaction mechanism.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Solomun</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Phys Chem B</MedlineTA>
<NlmUniqueID>101157530</NlmUniqueID>
<ISSNLinking>1520-5207</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>7440-57-5</RegistryNumber>
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<MeshHeading><DescriptorName UI="D006046" MajorTopicYN="N">Gold</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006147" MajorTopicYN="N">Guanine</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
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<MeshHeading><DescriptorName UI="D009841" MajorTopicYN="N">Oligonucleotides</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013816" MajorTopicYN="N">Thermodynamics</DescriptorName>
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<PublicationStatus>ppublish</PublicationStatus>
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DNA damage by low-energy electron impact: dependence on guanine content.

DNA damage by low-energy electron impact: dependence on guanine content.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki