Proanthocyanidins and the risk of colorectal cancer in Italy.
Identifieur interne : 001F81 ( PubMed/Corpus ); précédent : 001F80; suivant : 001F82Proanthocyanidins and the risk of colorectal cancer in Italy.
Auteurs : Marta Rossi ; Eva Negri ; Maria Parpinel ; Pagona Lagiou ; Cristina Bosetti ; Renato Talamini ; Maurizio Montella ; Attilio Giacosa ; Silvia Franceschi ; Carlo La VecchiaSource :
- Cancer causes & control : CCC [ 1573-7225 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Case-Control Studies, Colorectal Neoplasms (epidemiology), Colorectal Neoplasms (prevention & control), Female, Humans, Incidence, Italy (epidemiology), Male, Middle Aged, Odds Ratio, Proanthocyanidins (administration & dosage), Risk Assessment (statistics & numerical data), Surveys and Questionnaires.
- MESH :
- chemical , administration & dosage : Proanthocyanidins.
- geographic , epidemiology : Italy.
- epidemiology : Colorectal Neoplasms.
- prevention & control : Colorectal Neoplasms.
- statistics & numerical data : Risk Assessment.
- Adult, Aged, Case-Control Studies, Female, Humans, Incidence, Male, Middle Aged, Odds Ratio, Surveys and Questionnaires.
Abstract
Proanthocyanidins are a group of polymers of flavanols. Animal and in vitro studies suggest they decrease cancer risk, particularly of colorectal cancer. We used data from an Italian case-control study to investigate whether proanthocyanidins are related to colorectal cancer risk. Cases were 1,953 patients with incident, histologically confirmed colorectal cancer (1,225 colon cancers, 728 rectal cancers). Controls were 4,154 patients admitted for acute, non-neoplastic conditions. A reproducible and valid food frequency questionnaire was used. We estimated odds ratios (ORs) through multiple logistic regression models, including terms for potential confounding factors, and energy intake. A trend of decreasing risk with increasing intake of proanthocyanidins emerged for all classes except monomers. The OR for the highest vs. the lowest quintile of intake was 0.82 for monomers and dimers combined, 0.88 for monomers, 0.75 for dimers, 0.74 for all polymers with three or more mers, 0.84 for trimers, 0.80 for 4-6 mers, 0.79 for 7-10 mers, 0.69 for more than 10 mers, and 0.74 for total proanthocyanidins. The associations were apparently stronger for rectal than for colon cancer, in the absence of significant heterogeneity. These results may explain the protective effect of vegetables and fruit on colorectal cancer.
DOI: 10.1007/s10552-009-9455-3
PubMed: 20012183
Links to Exploration step
pubmed:20012183Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proanthocyanidins and the risk of colorectal cancer in Italy.</title><author><name sortKey="Rossi, Marta" sort="Rossi, Marta" uniqKey="Rossi M" first="Marta" last="Rossi">Marta Rossi</name><affiliation><nlm:affiliation>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. mrossi@marionegri.it</nlm:affiliation></affiliation></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name></author><author><name sortKey="Talamini, Renato" sort="Talamini, Renato" uniqKey="Talamini R" first="Renato" last="Talamini">Renato Talamini</name></author><author><name sortKey="Montella, Maurizio" sort="Montella, Maurizio" uniqKey="Montella M" first="Maurizio" last="Montella">Maurizio Montella</name></author><author><name sortKey="Giacosa, Attilio" sort="Giacosa, Attilio" uniqKey="Giacosa A" first="Attilio" last="Giacosa">Attilio Giacosa</name></author><author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20012183</idno><idno type="pmid">20012183</idno><idno type="doi">10.1007/s10552-009-9455-3</idno><idno type="wicri:Area/PubMed/Corpus">001F81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Proanthocyanidins and the risk of colorectal cancer in Italy.</title><author><name sortKey="Rossi, Marta" sort="Rossi, Marta" uniqKey="Rossi M" first="Marta" last="Rossi">Marta Rossi</name><affiliation><nlm:affiliation>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. mrossi@marionegri.it</nlm:affiliation></affiliation></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name></author><author><name sortKey="Talamini, Renato" sort="Talamini, Renato" uniqKey="Talamini R" first="Renato" last="Talamini">Renato Talamini</name></author><author><name sortKey="Montella, Maurizio" sort="Montella, Maurizio" uniqKey="Montella M" first="Maurizio" last="Montella">Maurizio Montella</name></author><author><name sortKey="Giacosa, Attilio" sort="Giacosa, Attilio" uniqKey="Giacosa A" first="Attilio" last="Giacosa">Attilio Giacosa</name></author><author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="eISSN">1573-7225</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Colorectal Neoplasms (epidemiology)</term><term>Colorectal Neoplasms (prevention & control)</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Italy (epidemiology)</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Proanthocyanidins (administration & dosage)</term><term>Risk Assessment (statistics & numerical data)</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Proanthocyanidins are a group of polymers of flavanols. Animal and in vitro studies suggest they decrease cancer risk, particularly of colorectal cancer. We used data from an Italian case-control study to investigate whether proanthocyanidins are related to colorectal cancer risk. Cases were 1,953 patients with incident, histologically confirmed colorectal cancer (1,225 colon cancers, 728 rectal cancers). Controls were 4,154 patients admitted for acute, non-neoplastic conditions. A reproducible and valid food frequency questionnaire was used. We estimated odds ratios (ORs) through multiple logistic regression models, including terms for potential confounding factors, and energy intake. A trend of decreasing risk with increasing intake of proanthocyanidins emerged for all classes except monomers. The OR for the highest vs. the lowest quintile of intake was 0.82 for monomers and dimers combined, 0.88 for monomers, 0.75 for dimers, 0.74 for all polymers with three or more mers, 0.84 for trimers, 0.80 for 4-6 mers, 0.79 for 7-10 mers, 0.69 for more than 10 mers, and 0.74 for total proanthocyanidins. The associations were apparently stronger for rectal than for colon cancer, in the absence of significant heterogeneity. These results may explain the protective effect of vegetables and fruit on colorectal cancer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20012183</PMID><DateCompleted><Year>2010</Year><Month>04</Month><Day>23</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7225</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Cancer causes & control : CCC</Title><ISOAbbreviation>Cancer Causes Control</ISOAbbreviation></Journal><ArticleTitle>Proanthocyanidins and the risk of colorectal cancer in Italy.</ArticleTitle><Pagination><MedlinePgn>243-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10552-009-9455-3</ELocationID><Abstract><AbstractText>Proanthocyanidins are a group of polymers of flavanols. Animal and in vitro studies suggest they decrease cancer risk, particularly of colorectal cancer. We used data from an Italian case-control study to investigate whether proanthocyanidins are related to colorectal cancer risk. Cases were 1,953 patients with incident, histologically confirmed colorectal cancer (1,225 colon cancers, 728 rectal cancers). Controls were 4,154 patients admitted for acute, non-neoplastic conditions. A reproducible and valid food frequency questionnaire was used. We estimated odds ratios (ORs) through multiple logistic regression models, including terms for potential confounding factors, and energy intake. A trend of decreasing risk with increasing intake of proanthocyanidins emerged for all classes except monomers. The OR for the highest vs. the lowest quintile of intake was 0.82 for monomers and dimers combined, 0.88 for monomers, 0.75 for dimers, 0.74 for all polymers with three or more mers, 0.84 for trimers, 0.80 for 4-6 mers, 0.79 for 7-10 mers, 0.69 for more than 10 mers, and 0.74 for total proanthocyanidins. The associations were apparently stronger for rectal than for colon cancer, in the absence of significant heterogeneity. These results may explain the protective effect of vegetables and fruit on colorectal cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. mrossi@marionegri.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Negri</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Parpinel</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lagiou</LastName><ForeName>Pagona</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Bosetti</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Talamini</LastName><ForeName>Renato</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Montella</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Giacosa</LastName><ForeName>Attilio</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Franceschi</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>La Vecchia</LastName><ForeName>Carlo</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>12</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Cancer Causes Control</MedlineTA><NlmUniqueID>9100846</NlmUniqueID><ISSNLinking>0957-5243</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044945">Proanthocyanidins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015179" MajorTopicYN="N">Colorectal Neoplasms</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044945" MajorTopicYN="N">Proanthocyanidins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>10</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>4</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20012183</ArticleId><ArticleId IdType="doi">10.1007/s10552-009-9455-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F81 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001F81 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:20012183
|texte= Proanthocyanidins and the risk of colorectal cancer in Italy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:20012183" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |