Flavonoids, proanthocyanidins, and the risk of stomach cancer.
Identifieur interne : 001F50 ( PubMed/Corpus ); précédent : 001F49; suivant : 001F51Flavonoids, proanthocyanidins, and the risk of stomach cancer.
Auteurs : Marta Rossi ; Valentina Rosato ; Cristina Bosetti ; Pagona Lagiou ; Maria Parpinel ; Paola Bertuccio ; Eva Negri ; Carlo La VecchiaSource :
- Cancer causes & control : CCC [ 1573-7225 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Beverages, Case-Control Studies, Diet, Feeding Behavior, Female, Flavonoids, Fruit, Humans, Italy (epidemiology), Logistic Models, Male, Middle Aged, Odds Ratio, Proanthocyanidins, Risk, Stomach Neoplasms (epidemiology), Stomach Neoplasms (etiology), Stomach Neoplasms (prevention & control), Vegetables, Young Adult.
- MESH :
- chemical : Flavonoids, Proanthocyanidins.
- epidemiology : Italy, Stomach Neoplasms.
- etiology : Stomach Neoplasms.
- prevention & control : Stomach Neoplasms.
- Adult, Aged, Aged, 80 and over, Beverages, Case-Control Studies, Diet, Feeding Behavior, Female, Fruit, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk, Vegetables, Young Adult.
Abstract
Flavonoids have been suggested to be responsible for the potential beneficial properties of fruit and vegetables on stomach cancer risk. To provide further information on flavonoids, proanthocyanidins, and gastric cancer risk, we analyzed data from a case-control study conducted in Italy. Subjects were 230 cases with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals of cases for acute, non-neoplastic conditions. Subjects were interviewed using a reproducible and valid food frequency questionnaire. We estimated the odds ratios (ORs) of gastric cancer and their corresponding 95% confidence intervals (CIs) using unconditional logistic regression models including terms for major recognized gastric cancer risk factors. The ORs of the highest quintile of intake compared to the lowest were below unity for all classes of flavonoids, in the absence, however, of significant associations. Strong inverse relations were found for proanthocyanidins. The OR was 0.44 (95% CI, 0.25-0.76) for monomers and dimers combined and 0.36 (95% CI, 0.21-0.63) for polymers with three or more mers. Further adjustment for fruit and vegetables, or vitamin C, did not materially change these associations. This is the first epidemiological study to suggest that dietary proanthocyanidins have a favorable role on gastric cancer risk.
DOI: 10.1007/s10552-010-9588-4
PubMed: 20521092
Links to Exploration step
pubmed:20521092Le document en format XML
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Parpinel</name></author><author><name sortKey="Bertuccio, Paola" sort="Bertuccio, Paola" uniqKey="Bertuccio P" first="Paola" last="Bertuccio">Paola Bertuccio</name></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20521092</idno><idno type="pmid">20521092</idno><idno type="doi">10.1007/s10552-010-9588-4</idno><idno type="wicri:Area/PubMed/Corpus">001F50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Flavonoids, proanthocyanidins, and the risk of stomach cancer.</title><author><name sortKey="Rossi, Marta" sort="Rossi, Marta" uniqKey="Rossi M" first="Marta" last="Rossi">Marta Rossi</name><affiliation><nlm:affiliation>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. mrossi@marionegri.it</nlm:affiliation></affiliation></author><author><name sortKey="Rosato, Valentina" sort="Rosato, Valentina" uniqKey="Rosato V" first="Valentina" last="Rosato">Valentina Rosato</name></author><author><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name></author><author><name sortKey="Parpinel, Maria" sort="Parpinel, Maria" uniqKey="Parpinel M" first="Maria" last="Parpinel">Maria Parpinel</name></author><author><name sortKey="Bertuccio, Paola" sort="Bertuccio, Paola" uniqKey="Bertuccio P" first="Paola" last="Bertuccio">Paola Bertuccio</name></author><author><name sortKey="Negri, Eva" sort="Negri, Eva" uniqKey="Negri E" first="Eva" last="Negri">Eva Negri</name></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="eISSN">1573-7225</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Beverages</term><term>Case-Control Studies</term><term>Diet</term><term>Feeding Behavior</term><term>Female</term><term>Flavonoids</term><term>Fruit</term><term>Humans</term><term>Italy (epidemiology)</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Proanthocyanidins</term><term>Risk</term><term>Stomach Neoplasms (epidemiology)</term><term>Stomach Neoplasms (etiology)</term><term>Stomach Neoplasms (prevention & control)</term><term>Vegetables</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Flavonoids</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Italy</term><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Stomach Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Beverages</term><term>Case-Control Studies</term><term>Diet</term><term>Feeding Behavior</term><term>Female</term><term>Fruit</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Risk</term><term>Vegetables</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Flavonoids have been suggested to be responsible for the potential beneficial properties of fruit and vegetables on stomach cancer risk. To provide further information on flavonoids, proanthocyanidins, and gastric cancer risk, we analyzed data from a case-control study conducted in Italy. Subjects were 230 cases with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals of cases for acute, non-neoplastic conditions. Subjects were interviewed using a reproducible and valid food frequency questionnaire. We estimated the odds ratios (ORs) of gastric cancer and their corresponding 95% confidence intervals (CIs) using unconditional logistic regression models including terms for major recognized gastric cancer risk factors. The ORs of the highest quintile of intake compared to the lowest were below unity for all classes of flavonoids, in the absence, however, of significant associations. Strong inverse relations were found for proanthocyanidins. The OR was 0.44 (95% CI, 0.25-0.76) for monomers and dimers combined and 0.36 (95% CI, 0.21-0.63) for polymers with three or more mers. Further adjustment for fruit and vegetables, or vitamin C, did not materially change these associations. This is the first epidemiological study to suggest that dietary proanthocyanidins have a favorable role on gastric cancer risk.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20521092</PMID><DateCompleted><Year>2011</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7225</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>10</Issue><PubDate><Year>2010</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Cancer causes & control : CCC</Title><ISOAbbreviation>Cancer Causes Control</ISOAbbreviation></Journal><ArticleTitle>Flavonoids, proanthocyanidins, and the risk of stomach cancer.</ArticleTitle><Pagination><MedlinePgn>1597-604</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10552-010-9588-4</ELocationID><Abstract><AbstractText>Flavonoids have been suggested to be responsible for the potential beneficial properties of fruit and vegetables on stomach cancer risk. To provide further information on flavonoids, proanthocyanidins, and gastric cancer risk, we analyzed data from a case-control study conducted in Italy. Subjects were 230 cases with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals of cases for acute, non-neoplastic conditions. Subjects were interviewed using a reproducible and valid food frequency questionnaire. We estimated the odds ratios (ORs) of gastric cancer and their corresponding 95% confidence intervals (CIs) using unconditional logistic regression models including terms for major recognized gastric cancer risk factors. The ORs of the highest quintile of intake compared to the lowest were below unity for all classes of flavonoids, in the absence, however, of significant associations. Strong inverse relations were found for proanthocyanidins. The OR was 0.44 (95% CI, 0.25-0.76) for monomers and dimers combined and 0.36 (95% CI, 0.21-0.63) for polymers with three or more mers. Further adjustment for fruit and vegetables, or vitamin C, did not materially change these associations. This is the first epidemiological study to suggest that dietary proanthocyanidins have a favorable role on gastric cancer risk.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. mrossi@marionegri.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosato</LastName><ForeName>Valentina</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Bosetti</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lagiou</LastName><ForeName>Pagona</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Parpinel</LastName><ForeName>Maria</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bertuccio</LastName><ForeName>Paola</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Negri</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>La Vecchia</LastName><ForeName>Carlo</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>06</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Cancer Causes Control</MedlineTA><NlmUniqueID>9100846</NlmUniqueID><ISSNLinking>0957-5243</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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MajorTopicYN="Y">Flavonoids</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N">Italy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044945" MajorTopicYN="Y">Proanthocyanidins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012306" 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