Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins.
Identifieur interne : 001D41 ( PubMed/Corpus ); précédent : 001D40; suivant : 001D42Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins.
Auteurs : Raghunath Chatterjee ; Jianfei Zhao ; Ximiao He ; Andrey Shlyakhtenko ; Ishminder Mann ; Joshua J. Waterfall ; Paul Meltzer ; B K Sathyanarayana ; Peter C. Fitzgerald ; Charles VinsonSource :
- G3 (Bethesda, Md.) [ 2160-1836 ] ; 2012.
English descriptors
- KwdEn :
- Animals, Base Sequence, Binding Sites, Conserved Sequence, Cyclic AMP Response Element-Binding Protein (chemistry), Cyclic AMP Response Element-Binding Protein (metabolism), DNA Methylation, GA-Binding Protein Transcription Factor (chemistry), GA-Binding Protein Transcription Factor (metabolism), Humans, Mice, Molecular Docking Simulation, Nucleic Acid Conformation, Nucleotide Motifs, Promoter Regions, Genetic, Protein Binding, Protein Conformation, Proto-Oncogene Proteins c-ets (chemistry), Proto-Oncogene Proteins c-ets (genetics).
- MESH :
- chemical , chemistry : Cyclic AMP Response Element-Binding Protein, GA-Binding Protein Transcription Factor, Proto-Oncogene Proteins c-ets.
- chemical , genetics : Proto-Oncogene Proteins c-ets.
- chemical , metabolism : Cyclic AMP Response Element-Binding Protein, GA-Binding Protein Transcription Factor.
- Animals, Base Sequence, Binding Sites, Conserved Sequence, DNA Methylation, Humans, Mice, Molecular Docking Simulation, Nucleic Acid Conformation, Nucleotide Motifs, Promoter Regions, Genetic, Protein Binding, Protein Conformation.
Abstract
Previously, we identified 8-bps long DNA sequences (8-mers) that localize in human proximal promoters and grouped them into known transcription factor binding sites (TFBS). We now examine split 8-mers consisting of two 4-mers separated by 1-bp to 30-bps (X(4)-N(1-30)-X(4)) to identify pairs of TFBS that localize in proximal promoters at a precise distance. These include two overlapping TFBS: the ETS⇔ETS motif ((C/G)CCGGAAGCGGAA) and the ETS⇔CRE motif ((C/G)CGGAAGTGACGTCAC). The nucleotides in bold are part of both TFBS. Molecular modeling shows that the ETS⇔CRE motif can be bound simultaneously by both the ETS and the B-ZIP domains without protein-protein clashes. The electrophoretic mobility shift assay (EMSA) shows that the ETS protein GABPα and the B-ZIP protein CREB preferentially bind to the ETS⇔CRE motif only when the two TFBS overlap precisely. In contrast, the ETS domain of ETV5 and CREB interfere with each other for binding the ETS⇔CRE. The 11-mer (CGGAAGTGACG), the conserved part of the ETS⇔CRE motif, occurs 226 times in the human genome and 83% are in known regulatory regions. In vivo GABPα and CREB ChIP-seq peaks identified the ETS⇔CRE as the most enriched motif occurring in promoters of genes involved in mRNA processing, cellular catabolic processes, and stress response, suggesting that a specific class of genes is regulated by this composite motif.
DOI: 10.1534/g3.112.004002
PubMed: 23050235
Links to Exploration step
pubmed:23050235Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins.</title><author><name sortKey="Chatterjee, Raghunath" sort="Chatterjee, Raghunath" uniqKey="Chatterjee R" first="Raghunath" last="Chatterjee">Raghunath Chatterjee</name><affiliation><nlm:affiliation>Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jianfei" sort="Zhao, Jianfei" uniqKey="Zhao J" first="Jianfei" last="Zhao">Jianfei Zhao</name></author><author><name sortKey="He, Ximiao" sort="He, Ximiao" uniqKey="He X" first="Ximiao" last="He">Ximiao He</name></author><author><name sortKey="Shlyakhtenko, Andrey" sort="Shlyakhtenko, Andrey" uniqKey="Shlyakhtenko A" first="Andrey" last="Shlyakhtenko">Andrey Shlyakhtenko</name></author><author><name sortKey="Mann, Ishminder" sort="Mann, Ishminder" uniqKey="Mann I" first="Ishminder" last="Mann">Ishminder Mann</name></author><author><name sortKey="Waterfall, Joshua J" sort="Waterfall, Joshua J" uniqKey="Waterfall J" first="Joshua J" last="Waterfall">Joshua J. Waterfall</name></author><author><name sortKey="Meltzer, Paul" sort="Meltzer, Paul" uniqKey="Meltzer P" first="Paul" last="Meltzer">Paul Meltzer</name></author><author><name sortKey="Sathyanarayana, B K" sort="Sathyanarayana, B K" uniqKey="Sathyanarayana B" first="B K" last="Sathyanarayana">B K Sathyanarayana</name></author><author><name sortKey="Fitzgerald, Peter C" sort="Fitzgerald, Peter C" uniqKey="Fitzgerald P" first="Peter C" last="Fitzgerald">Peter C. Fitzgerald</name></author><author><name sortKey="Vinson, Charles" sort="Vinson, Charles" uniqKey="Vinson C" first="Charles" last="Vinson">Charles Vinson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23050235</idno><idno type="pmid">23050235</idno><idno type="doi">10.1534/g3.112.004002</idno><idno type="wicri:Area/PubMed/Corpus">001D41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins.</title><author><name sortKey="Chatterjee, Raghunath" sort="Chatterjee, Raghunath" uniqKey="Chatterjee R" first="Raghunath" last="Chatterjee">Raghunath Chatterjee</name><affiliation><nlm:affiliation>Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jianfei" sort="Zhao, Jianfei" uniqKey="Zhao J" first="Jianfei" last="Zhao">Jianfei Zhao</name></author><author><name sortKey="He, Ximiao" sort="He, Ximiao" uniqKey="He X" first="Ximiao" last="He">Ximiao He</name></author><author><name sortKey="Shlyakhtenko, Andrey" sort="Shlyakhtenko, Andrey" uniqKey="Shlyakhtenko A" first="Andrey" last="Shlyakhtenko">Andrey Shlyakhtenko</name></author><author><name sortKey="Mann, Ishminder" sort="Mann, Ishminder" uniqKey="Mann I" first="Ishminder" last="Mann">Ishminder Mann</name></author><author><name sortKey="Waterfall, Joshua J" sort="Waterfall, Joshua J" uniqKey="Waterfall J" first="Joshua J" last="Waterfall">Joshua J. Waterfall</name></author><author><name sortKey="Meltzer, Paul" sort="Meltzer, Paul" uniqKey="Meltzer P" first="Paul" last="Meltzer">Paul Meltzer</name></author><author><name sortKey="Sathyanarayana, B K" sort="Sathyanarayana, B K" uniqKey="Sathyanarayana B" first="B K" last="Sathyanarayana">B K Sathyanarayana</name></author><author><name sortKey="Fitzgerald, Peter C" sort="Fitzgerald, Peter C" uniqKey="Fitzgerald P" first="Peter C" last="Fitzgerald">Peter C. Fitzgerald</name></author><author><name sortKey="Vinson, Charles" sort="Vinson, Charles" uniqKey="Vinson C" first="Charles" last="Vinson">Charles Vinson</name></author></analytic><series><title level="j">G3 (Bethesda, Md.)</title><idno type="eISSN">2160-1836</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Binding Sites</term><term>Conserved Sequence</term><term>Cyclic AMP Response Element-Binding Protein (chemistry)</term><term>Cyclic AMP Response Element-Binding Protein (metabolism)</term><term>DNA Methylation</term><term>GA-Binding Protein Transcription Factor (chemistry)</term><term>GA-Binding Protein Transcription Factor (metabolism)</term><term>Humans</term><term>Mice</term><term>Molecular Docking Simulation</term><term>Nucleic Acid Conformation</term><term>Nucleotide Motifs</term><term>Promoter Regions, Genetic</term><term>Protein Binding</term><term>Protein Conformation</term><term>Proto-Oncogene Proteins c-ets (chemistry)</term><term>Proto-Oncogene Proteins c-ets (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cyclic AMP Response Element-Binding Protein</term><term>GA-Binding Protein Transcription Factor</term><term>Proto-Oncogene Proteins c-ets</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proto-Oncogene Proteins c-ets</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclic AMP Response Element-Binding Protein</term><term>GA-Binding Protein Transcription Factor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Binding Sites</term><term>Conserved Sequence</term><term>DNA Methylation</term><term>Humans</term><term>Mice</term><term>Molecular Docking Simulation</term><term>Nucleic Acid Conformation</term><term>Nucleotide Motifs</term><term>Promoter Regions, Genetic</term><term>Protein Binding</term><term>Protein Conformation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previously, we identified 8-bps long DNA sequences (8-mers) that localize in human proximal promoters and grouped them into known transcription factor binding sites (TFBS). We now examine split 8-mers consisting of two 4-mers separated by 1-bp to 30-bps (X(4)-N(1-30)-X(4)) to identify pairs of TFBS that localize in proximal promoters at a precise distance. These include two overlapping TFBS: the ETS⇔ETS motif ((C/G)CCGGAAGCGGAA) and the ETS⇔CRE motif ((C/G)CGGAAGTGACGTCAC). The nucleotides in bold are part of both TFBS. Molecular modeling shows that the ETS⇔CRE motif can be bound simultaneously by both the ETS and the B-ZIP domains without protein-protein clashes. The electrophoretic mobility shift assay (EMSA) shows that the ETS protein GABPα and the B-ZIP protein CREB preferentially bind to the ETS⇔CRE motif only when the two TFBS overlap precisely. In contrast, the ETS domain of ETV5 and CREB interfere with each other for binding the ETS⇔CRE. The 11-mer (CGGAAGTGACG), the conserved part of the ETS⇔CRE motif, occurs 226 times in the human genome and 83% are in known regulatory regions. In vivo GABPα and CREB ChIP-seq peaks identified the ETS⇔CRE as the most enriched motif occurring in promoters of genes involved in mRNA processing, cellular catabolic processes, and stress response, suggesting that a specific class of genes is regulated by this composite motif.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23050235</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>17</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2160-1836</ISSN><JournalIssue CitedMedium="Internet"><Volume>2</Volume><Issue>10</Issue><PubDate><Year>2012</Year><Month>Oct</Month></PubDate></JournalIssue><Title>G3 (Bethesda, Md.)</Title><ISOAbbreviation>G3 (Bethesda)</ISOAbbreviation></Journal><ArticleTitle>Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins.</ArticleTitle><Pagination><MedlinePgn>1243-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1534/g3.112.004002</ELocationID><Abstract><AbstractText>Previously, we identified 8-bps long DNA sequences (8-mers) that localize in human proximal promoters and grouped them into known transcription factor binding sites (TFBS). We now examine split 8-mers consisting of two 4-mers separated by 1-bp to 30-bps (X(4)-N(1-30)-X(4)) to identify pairs of TFBS that localize in proximal promoters at a precise distance. These include two overlapping TFBS: the ETS⇔ETS motif ((C/G)CCGGAAGCGGAA) and the ETS⇔CRE motif ((C/G)CGGAAGTGACGTCAC). The nucleotides in bold are part of both TFBS. Molecular modeling shows that the ETS⇔CRE motif can be bound simultaneously by both the ETS and the B-ZIP domains without protein-protein clashes. The electrophoretic mobility shift assay (EMSA) shows that the ETS protein GABPα and the B-ZIP protein CREB preferentially bind to the ETS⇔CRE motif only when the two TFBS overlap precisely. In contrast, the ETS domain of ETV5 and CREB interfere with each other for binding the ETS⇔CRE. The 11-mer (CGGAAGTGACG), the conserved part of the ETS⇔CRE motif, occurs 226 times in the human genome and 83% are in known regulatory regions. In vivo GABPα and CREB ChIP-seq peaks identified the ETS⇔CRE as the most enriched motif occurring in promoters of genes involved in mRNA processing, cellular catabolic processes, and stress response, suggesting that a specific class of genes is regulated by this composite motif.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chatterjee</LastName><ForeName>Raghunath</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jianfei</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Ximiao</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Shlyakhtenko</LastName><ForeName>Andrey</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mann</LastName><ForeName>Ishminder</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Waterfall</LastName><ForeName>Joshua J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Meltzer</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Sathyanarayana</LastName><ForeName>B K</ForeName><Initials>BK</Initials></Author><Author ValidYN="Y"><LastName>FitzGerald</LastName><ForeName>Peter C</ForeName><Initials>PC</Initials></Author><Author ValidYN="Y"><LastName>Vinson</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>10</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>G3 (Bethesda)</MedlineTA><NlmUniqueID>101566598</NlmUniqueID><ISSNLinking>2160-1836</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017362">Cyclic AMP Response Element-Binding Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051268">GA-Binding Protein Transcription Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495661">GABPA protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050783">Proto-Oncogene Proteins c-ets</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017124" MajorTopicYN="N">Conserved Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017362" MajorTopicYN="N">Cyclic AMP Response Element-Binding Protein</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019175" MajorTopicYN="N">DNA Methylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051268" MajorTopicYN="N">GA-Binding Protein Transcription Factor</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009690" MajorTopicYN="N">Nucleic Acid Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059372" MajorTopicYN="Y">Nucleotide Motifs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011401" MajorTopicYN="Y">Promoter Regions, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050783" MajorTopicYN="N">Proto-Oncogene Proteins c-ets</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">EMSA</Keyword><Keyword MajorTopicYN="N">co-localization</Keyword><Keyword MajorTopicYN="N">proximal promoters</Keyword><Keyword MajorTopicYN="N">transcription factor binding sites</Keyword><Keyword MajorTopicYN="N">transcriptional start site</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>08</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>10</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>10</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23050235</ArticleId><ArticleId IdType="doi">10.1534/g3.112.004002</ArticleId><ArticleId IdType="pii">GGG_004002</ArticleId><ArticleId IdType="pmc">PMC3464117</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Genome Biol. 2002;3(12):RESEARCH0087</Citation><ArticleIdList><ArticleId IdType="pubmed">12537576</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Mar;40(5):e38</Citation><ArticleIdList><ArticleId IdType="pubmed">22187154</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biochem. 2003;72:449-79</Citation><ArticleIdList><ArticleId IdType="pubmed">12651739</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2004;32(3):949-58</Citation><ArticleIdList><ArticleId IdType="pubmed">14963262</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4537-42</Citation><ArticleIdList><ArticleId IdType="pubmed">15070753</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comput Chem. 2004 Oct;25(13):1605-12</Citation><ArticleIdList><ArticleId IdType="pubmed">15264254</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2004 Aug;14(8):1562-74</Citation><ArticleIdList><ArticleId IdType="pubmed">15256515</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1989 May;3(5):612-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2545524</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1993 Nov;13(11):6919-30</Citation><ArticleIdList><ArticleId IdType="pubmed">8413284</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 1996 May 24;258(5):800-12</Citation><ArticleIdList><ArticleId IdType="pubmed">8637011</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1997 Sep;17(9):4885-94</Citation><ArticleIdList><ArticleId IdType="pubmed">9271368</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 1998 Jan 1;12(1):34-44</Citation><ArticleIdList><ArticleId IdType="pubmed">9420329</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1998 Feb;18(2):967-77</Citation><ArticleIdList><ArticleId IdType="pubmed">9447994</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1998 Feb 13;279(5353):1037-41</Citation><ArticleIdList><ArticleId IdType="pubmed">9461436</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Cancer Res. 1998;75:1-55</Citation><ArticleIdList><ArticleId IdType="pubmed">9709806</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics. 2004 Dec;84(6):929-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15533710</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2004 Nov 10;23(22):4384-93</Citation><ArticleIdList><ArticleId IdType="pubmed">15510218</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2005 Mar 17;434(7031):338-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15735639</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4459-64</Citation><ArticleIdList><ArticleId IdType="pubmed">15753290</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2006 Jan 1;34(Database issue):D108-10</Citation><ArticleIdList><ArticleId IdType="pubmed">16381825</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2006 Jun;38(6):626-35</Citation><ArticleIdList><ArticleId IdType="pubmed">16645617</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2007 Jan;35(Database issue):D127-31</Citation><ArticleIdList><ArticleId IdType="pubmed">17130146</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2006;7(7):R53</Citation><ArticleIdList><ArticleId IdType="pubmed">16827941</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2007 Jun 8;316(5830):1497-502</Citation><ArticleIdList><ArticleId IdType="pubmed">17540862</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2007 Aug 3;282(31):22816-22</Citation><ArticleIdList><ArticleId IdType="pubmed">17526488</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2008;9:67</Citation><ArticleIdList><ArticleId IdType="pubmed">18252004</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Struct Biol. 2008 Apr;18(2):236-42</Citation><ArticleIdList><ArticleId IdType="pubmed">18206362</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2008 Nov;26(11):1293-300</Citation><ArticleIdList><ArticleId IdType="pubmed">18978777</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Biotechnol. 2008 Dec;26(12):1351-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19029915</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2008 Dec 12;135(6):1053-64</Citation><ArticleIdList><ArticleId IdType="pubmed">19070576</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Methods. 2008 Sep;5(9):829-34</Citation><ArticleIdList><ArticleId IdType="pubmed">19160518</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Jun 26;324(5935):1720-3</Citation><ArticleIdList><ArticleId IdType="pubmed">19443739</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2009 Sep;10(9):605-16</Citation><ArticleIdList><ArticleId IdType="pubmed">19668247</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Genet. 2009 Oct;25(10):434-40</Citation><ArticleIdList><ArticleId IdType="pubmed">19815308</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2010 Jan;38(Database issue):D105-10</Citation><ArticleIdList><ArticleId IdType="pubmed">19906716</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2010 Jan;20(1):110-21</Citation><ArticleIdList><ArticleId IdType="pubmed">19858363</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2010 Jul 7;29(13):2147-60</Citation><ArticleIdList><ArticleId IdType="pubmed">20517297</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Genomics. 2010;11:530</Citation><ArticleIdList><ArticleId IdType="pubmed">20920259</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20311-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21059933</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22534-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21149679</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2010;11(11):140</Citation><ArticleIdList><ArticleId IdType="pubmed">21118582</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2011 May 27;409(1):47-53</Citation><ArticleIdList><ArticleId IdType="pubmed">21295585</ArticleId></ArticleIdList></Reference><Reference><Citation>Subcell Biochem. 2011;52:205-22</Citation><ArticleIdList><ArticleId IdType="pubmed">21557085</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2011 Jun 15;27(12):1696-7</Citation><ArticleIdList><ArticleId IdType="pubmed">21486936</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Biochem. 2011;80:437-71</Citation><ArticleIdList><ArticleId IdType="pubmed">21548782</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2011 Jul 8;43(1):145-55</Citation><ArticleIdList><ArticleId IdType="pubmed">21726817</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Dec 10;274(50):35475-82</Citation><ArticleIdList><ArticleId IdType="pubmed">10585419</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Immunol. 2000 Apr;30(4):1102-12</Citation><ArticleIdList><ArticleId IdType="pubmed">10760799</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2000 Nov 10;275(45):35242-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10952992</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2001 Dec;8(6):1267-76</Citation><ArticleIdList><ArticleId IdType="pubmed">11779502</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2002 Jul 15;30(14):3214-24</Citation><ArticleIdList><ArticleId IdType="pubmed">12136103</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2011 Aug;39(15):e98</Citation><ArticleIdList><ArticleId IdType="pubmed">21602262</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2011 Oct 15;25(20):2147-57</Citation><ArticleIdList><ArticleId IdType="pubmed">22012618</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Feb;40(4):e31</Citation><ArticleIdList><ArticleId IdType="pubmed">22156162</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2003 Jul 1;31(13):3576-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12824369</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D41 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001D41 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:23050235
|texte= Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:23050235" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |