Mild encephalitis/encephalopathy with a reversible splenial lesion in children.
Identifieur interne : 001D01 ( PubMed/Corpus ); précédent : 001D00; suivant : 001D02Mild encephalitis/encephalopathy with a reversible splenial lesion in children.
Auteurs : Zoltán Liptai ; Balázs Ivády ; Péter Barsi ; György Várallyay ; Gábor Rudas ; András FogarasiSource :
- Ideggyogyaszati szemle [ 0019-1442 ] ; 2013.
English descriptors
- KwdEn :
- Adolescent, Anti-Inflammatory Agents (administration & dosage), Antipyretics (administration & dosage), Aspirin (administration & dosage), Brain (pathology), Brain Edema (etiology), Brain Edema (pathology), Child, Corpus Callosum (pathology), Diuretics, Osmotic (administration & dosage), Encephalitis (complications), Encephalitis (diagnosis), Encephalitis (drug therapy), Encephalitis (pathology), Encephalitis, Viral (diagnosis), Female, Humans, Ischemic Attack, Transient (etiology), Ischemic Attack, Transient (pathology), Magnetic Resonance Angiography, Magnetic Resonance Imaging, Mannitol (administration & dosage), Methylprednisolone (administration & dosage), Neuroprotective Agents (administration & dosage), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Antipyretics, Aspirin, Diuretics, Osmotic, Mannitol, Methylprednisolone, Neuroprotective Agents.
- complications : Encephalitis.
- diagnosis : Encephalitis, Encephalitis, Viral.
- drug therapy : Encephalitis.
- etiology : Brain Edema, Ischemic Attack, Transient.
- pathology : Brain, Brain Edema, Corpus Callosum, Encephalitis, Ischemic Attack, Transient.
- Adolescent, Child, Female, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Treatment Outcome.
Abstract
Authors, most of them Japanese, have recently published an increasing number of articles on mild encephalitis/encephalopathy with a reversible splenial lesion. We report on two new white European patients and compare published data with our own observations. A 15-year-old girl developed headache, fever, dizziness, vomiting and nuchal rigidity over four days. CSF showed elevated protein and cell count, with the lowest serum Na being 131 mmol/L. MRI on day seven was normal, but she remained febrile, had cerebral edema and episodes of confusion. MRI on day 11 showed a small T2-hyperintense lesion with restricted diffusion in the callosal splenium. Adenoviral infection was proved, and the girl underwent a protracted course of recovery. MRI signal changes improved in six days and disappeared after four months. A 12.5-year-old girl developed headache, lethargy, drowsiness and vomiting. On day five she experienced right-sided numbness, weakness and inability to speak which lasted 12 hours. She was confused and disoriented. MRI disclosed a tiny area of increased T2-signal and restricted diffusion in the splenium. Serum Na was 133 mmol/L, CSF cell count and protein was markedly elevated, and enteroviral infection was detected. Echocardiography showed no changes predisposing to clot formation and no thrombophilia was found. Her symptoms resolved in a week and MRI was normal two months later. These two non-epileptic children increase the small number of white European patients with MERS reported so far. Both had hyponatremia and encephalitis and patient 2 had transient ischemic attack, possibly due to the cerebral edema also resulting in the splenial lesion.
PubMed: 23607233
Links to Exploration step
pubmed:23607233Le document en format XML
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<author><name sortKey="Liptai, Zoltan" sort="Liptai, Zoltan" uniqKey="Liptai Z" first="Zoltán" last="Liptai">Zoltán Liptai</name>
<affiliation><nlm:affiliation>Department of Paediatrics, Szent László Hospital, Budapest. zliptai@laszlokorhaz.hu</nlm:affiliation>
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<author><name sortKey="Ivady, Balazs" sort="Ivady, Balazs" uniqKey="Ivady B" first="Balázs" last="Ivády">Balázs Ivády</name>
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<author><name sortKey="Barsi, Peter" sort="Barsi, Peter" uniqKey="Barsi P" first="Péter" last="Barsi">Péter Barsi</name>
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<author><name sortKey="Varallyay, Gyorgy" sort="Varallyay, Gyorgy" uniqKey="Varallyay G" first="György" last="Várallyay">György Várallyay</name>
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<author><name sortKey="Rudas, Gabor" sort="Rudas, Gabor" uniqKey="Rudas G" first="Gábor" last="Rudas">Gábor Rudas</name>
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<author><name sortKey="Fogarasi, Andras" sort="Fogarasi, Andras" uniqKey="Fogarasi A" first="András" last="Fogarasi">András Fogarasi</name>
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<author><name sortKey="Ivady, Balazs" sort="Ivady, Balazs" uniqKey="Ivady B" first="Balázs" last="Ivády">Balázs Ivády</name>
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<author><name sortKey="Barsi, Peter" sort="Barsi, Peter" uniqKey="Barsi P" first="Péter" last="Barsi">Péter Barsi</name>
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<term>Aspirin (administration & dosage)</term>
<term>Brain (pathology)</term>
<term>Brain Edema (etiology)</term>
<term>Brain Edema (pathology)</term>
<term>Child</term>
<term>Corpus Callosum (pathology)</term>
<term>Diuretics, Osmotic (administration & dosage)</term>
<term>Encephalitis (complications)</term>
<term>Encephalitis (diagnosis)</term>
<term>Encephalitis (drug therapy)</term>
<term>Encephalitis (pathology)</term>
<term>Encephalitis, Viral (diagnosis)</term>
<term>Female</term>
<term>Humans</term>
<term>Ischemic Attack, Transient (etiology)</term>
<term>Ischemic Attack, Transient (pathology)</term>
<term>Magnetic Resonance Angiography</term>
<term>Magnetic Resonance Imaging</term>
<term>Mannitol (administration & dosage)</term>
<term>Methylprednisolone (administration & dosage)</term>
<term>Neuroprotective Agents (administration & dosage)</term>
<term>Treatment Outcome</term>
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<term>Mannitol</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Encephalitis</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Encephalitis</term>
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<term>Female</term>
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<front><div type="abstract" xml:lang="en">Authors, most of them Japanese, have recently published an increasing number of articles on mild encephalitis/encephalopathy with a reversible splenial lesion. We report on two new white European patients and compare published data with our own observations. A 15-year-old girl developed headache, fever, dizziness, vomiting and nuchal rigidity over four days. CSF showed elevated protein and cell count, with the lowest serum Na being 131 mmol/L. MRI on day seven was normal, but she remained febrile, had cerebral edema and episodes of confusion. MRI on day 11 showed a small T2-hyperintense lesion with restricted diffusion in the callosal splenium. Adenoviral infection was proved, and the girl underwent a protracted course of recovery. MRI signal changes improved in six days and disappeared after four months. A 12.5-year-old girl developed headache, lethargy, drowsiness and vomiting. On day five she experienced right-sided numbness, weakness and inability to speak which lasted 12 hours. She was confused and disoriented. MRI disclosed a tiny area of increased T2-signal and restricted diffusion in the splenium. Serum Na was 133 mmol/L, CSF cell count and protein was markedly elevated, and enteroviral infection was detected. Echocardiography showed no changes predisposing to clot formation and no thrombophilia was found. Her symptoms resolved in a week and MRI was normal two months later. These two non-epileptic children increase the small number of white European patients with MERS reported so far. Both had hyponatremia and encephalitis and patient 2 had transient ischemic attack, possibly due to the cerebral edema also resulting in the splenial lesion.</div>
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<Abstract><AbstractText>Authors, most of them Japanese, have recently published an increasing number of articles on mild encephalitis/encephalopathy with a reversible splenial lesion. We report on two new white European patients and compare published data with our own observations. A 15-year-old girl developed headache, fever, dizziness, vomiting and nuchal rigidity over four days. CSF showed elevated protein and cell count, with the lowest serum Na being 131 mmol/L. MRI on day seven was normal, but she remained febrile, had cerebral edema and episodes of confusion. MRI on day 11 showed a small T2-hyperintense lesion with restricted diffusion in the callosal splenium. Adenoviral infection was proved, and the girl underwent a protracted course of recovery. MRI signal changes improved in six days and disappeared after four months. A 12.5-year-old girl developed headache, lethargy, drowsiness and vomiting. On day five she experienced right-sided numbness, weakness and inability to speak which lasted 12 hours. She was confused and disoriented. MRI disclosed a tiny area of increased T2-signal and restricted diffusion in the splenium. Serum Na was 133 mmol/L, CSF cell count and protein was markedly elevated, and enteroviral infection was detected. Echocardiography showed no changes predisposing to clot formation and no thrombophilia was found. Her symptoms resolved in a week and MRI was normal two months later. These two non-epileptic children increase the small number of white European patients with MERS reported so far. Both had hyponatremia and encephalitis and patient 2 had transient ischemic attack, possibly due to the cerebral edema also resulting in the splenial lesion.</AbstractText>
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