MersV1, PubMed, Corpus, bibRecord, 001A86

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Identifieur interne : 001A86 ( PubMed/Corpus ); précédent : 001A85; suivant : 001A87

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Auteurs : Xinrong Tao ; Feng Mei ; Anurodh Agrawal ; Clarence J. Peters ; Thomas G. Ksiazek ; Xiaodong Cheng ; Chien-Te K. Tseng

Source :

Journal of virology [ 1098-5514 ] ; 2014.

RBID : pubmed:24453361

English descriptors

KwdEn :
- Animals, Cell Line, Chlorocebus aethiops, Coronavirus (drug effects), Coronavirus (physiology), Cyclic AMP (metabolism), Gene Knockdown Techniques, Guanine Nucleotide Exchange Factors (antagonists & inhibitors), Guanine Nucleotide Exchange Factors (genetics), Host-Pathogen Interactions, Humans, Virus Replication (drug effects).
MESH :
- chemical , antagonists & inhibitors : Guanine Nucleotide Exchange Factors.
- chemical , genetics : Guanine Nucleotide Exchange Factors.
- chemical , metabolism : Cyclic AMP.
- drug effects : Coronavirus, Virus Replication.
- physiology : Coronavirus.
- Animals, Cell Line, Chlorocebus aethiops, Gene Knockdown Techniques, Host-Pathogen Interactions, Humans.

Abstract

The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection.

DOI: 10.1128/JVI.03001-13
PubMed: 24453361

Links to Exploration step

pubmed:24453361

Le document en format XML

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<front><div type="abstract" xml:lang="en">The outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections and diseases represents a potential threat for worldwide spread and requires development of effective therapeutic strategies. In this study, we revealed a novel positive function of an exchange protein directly activated by cyclic AMP 1 (cAMP-1; Epac-1) on MERS-CoV replication. Specifically, we have shown that Epac-specific inhibitor treatment or silencing Epac-1 gene expression rendered cells resistant to viral infection. We believe Epac-1 inhibitors deserve further study as potential therapeutic agents for MERS-CoV infection. </div>
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Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.

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