Overlapping MERS and mild AESD caused by HHV-6 infection.
Identifieur interne : 001967 ( PubMed/Corpus ); précédent : 001966; suivant : 001968Overlapping MERS and mild AESD caused by HHV-6 infection.
Auteurs : Mari Hatanaka ; Mitsuru Kashiwagi ; Takuya Tanabe ; Hiroshi Nakahara ; Kazumi Ohta ; Hiroshi TamaiSource :
- Brain & development [ 1872-7131 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- complications : Roseolovirus Infections.
- etiology : Encephalitis, Viral, Seizures.
- pathogenicity : Herpesvirus 6, Human.
- pathology : Corpus Callosum, Encephalitis, Viral, Seizures, White Matter.
- Acute Disease, Female, Humans, Infant, Syndrome.
Abstract
We report the case of an overlapping encephalopathy syndrome consisting of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and a mild form of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) caused by human herpesvirus-6. A previously healthy 17-month-old girl was admitted to our hospital as a precaution because of seizures that had developed more than 25 hours (h) after fever. Brain diffusion-weighted images (DWI) showed high signal intensity in the central splenial region on Day 2. She regained consciousness 16 h after the second seizure. On Day 6, she had a secondary cluster of partial seizures. DWI showed resolution of the splenial lesion and revealed reduced diffusion in the fronto-subcortical white matter. She regained consciousness 36 h after the secondary cluster of seizures without any sequelae. A third DWI performed on Day 15 showed that the fronto-subcortical white matter lesions had completely disappeared. Based on the clinicoradiological findings, we diagnosed the patient with overlapping MERS and mild AESD. Our case, together with previous reports, suggests that patients can develop combined encephalopathy syndromes as a phenotype. Many encephalopathy syndromes have been established and classified; however, some may not present as independent syndromes.
DOI: 10.1016/j.braindev.2014.04.011
PubMed: 24856142
Links to Exploration step
pubmed:24856142Le document en format XML
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<author><name sortKey="Hatanaka, Mari" sort="Hatanaka, Mari" uniqKey="Hatanaka M" first="Mari" last="Hatanaka">Mari Hatanaka</name>
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<author><name sortKey="Nakahara, Hiroshi" sort="Nakahara, Hiroshi" uniqKey="Nakahara H" first="Hiroshi" last="Nakahara">Hiroshi Nakahara</name>
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<series><title level="j">Brain & development</title>
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<term>Corpus Callosum (pathology)</term>
<term>Encephalitis, Viral (etiology)</term>
<term>Encephalitis, Viral (pathology)</term>
<term>Female</term>
<term>Herpesvirus 6, Human (pathogenicity)</term>
<term>Humans</term>
<term>Infant</term>
<term>Roseolovirus Infections (complications)</term>
<term>Seizures (etiology)</term>
<term>Seizures (pathology)</term>
<term>Syndrome</term>
<term>White Matter (pathology)</term>
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<term>Encephalitis, Viral</term>
<term>Seizures</term>
<term>White Matter</term>
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<front><div type="abstract" xml:lang="en">We report the case of an overlapping encephalopathy syndrome consisting of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and a mild form of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) caused by human herpesvirus-6. A previously healthy 17-month-old girl was admitted to our hospital as a precaution because of seizures that had developed more than 25 hours (h) after fever. Brain diffusion-weighted images (DWI) showed high signal intensity in the central splenial region on Day 2. She regained consciousness 16 h after the second seizure. On Day 6, she had a secondary cluster of partial seizures. DWI showed resolution of the splenial lesion and revealed reduced diffusion in the fronto-subcortical white matter. She regained consciousness 36 h after the secondary cluster of seizures without any sequelae. A third DWI performed on Day 15 showed that the fronto-subcortical white matter lesions had completely disappeared. Based on the clinicoradiological findings, we diagnosed the patient with overlapping MERS and mild AESD. Our case, together with previous reports, suggests that patients can develop combined encephalopathy syndromes as a phenotype. Many encephalopathy syndromes have been established and classified; however, some may not present as independent syndromes.</div>
</front>
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<Title>Brain & development</Title>
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<Abstract><AbstractText>We report the case of an overlapping encephalopathy syndrome consisting of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and a mild form of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) caused by human herpesvirus-6. A previously healthy 17-month-old girl was admitted to our hospital as a precaution because of seizures that had developed more than 25 hours (h) after fever. Brain diffusion-weighted images (DWI) showed high signal intensity in the central splenial region on Day 2. She regained consciousness 16 h after the second seizure. On Day 6, she had a secondary cluster of partial seizures. DWI showed resolution of the splenial lesion and revealed reduced diffusion in the fronto-subcortical white matter. She regained consciousness 36 h after the secondary cluster of seizures without any sequelae. A third DWI performed on Day 15 showed that the fronto-subcortical white matter lesions had completely disappeared. Based on the clinicoradiological findings, we diagnosed the patient with overlapping MERS and mild AESD. Our case, together with previous reports, suggests that patients can develop combined encephalopathy syndromes as a phenotype. Many encephalopathy syndromes have been established and classified; however, some may not present as independent syndromes.</AbstractText>
<CopyrightInformation>Copyright © 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
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<ForeName>Mari</ForeName>
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