Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors.
Identifieur interne : 001960 ( PubMed/Corpus ); précédent : 001959; suivant : 001961Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors.
Auteurs : Robert L. LafeminaSource :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2014.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Cell Line, Drug Repositioning, High-Throughput Screening Assays, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Middle East Respiratory Syndrome Coronavirus (physiology), SARS Virus (drug effects), SARS Virus (pathogenicity), SARS Virus (physiology), Small Molecule Libraries (pharmacology).
- MESH :
- chemical , pharmacology : Antiviral Agents, Small Molecule Libraries.
- drug effects : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- Cell Line, Drug Repositioning, High-Throughput Screening Assays, Humans.
Abstract
Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. Two Antimicrobial Agents and Chemotherapy (AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV.
DOI: 10.1128/AAC.03406-14
PubMed: 24867994
Links to Exploration step
pubmed:24867994Le document en format XML
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<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
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<front><div type="abstract" xml:lang="en">Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. Two Antimicrobial Agents and Chemotherapy (AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV. </div>
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<Abstract><AbstractText>Two coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. Two Antimicrobial Agents and Chemotherapy (AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV. </AbstractText>
<CopyrightInformation>Copyright © 2014, American Society for Microbiology. All Rights Reserved.</CopyrightInformation>
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<ReferenceList><Reference><Citation>Antivir Chem Chemother. 2006;17(5):275-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17176632</ArticleId>
</ArticleIdList>
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<Reference><Citation>Antimicrob Agents Chemother. 2012 Sep;56(9):4718-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22733076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24841273</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24841269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2014 Aug;58(8):4894-8</Citation>
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